product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-10 Monoclonal Antibody (JES5-16E3), Functional Grade, eBioscience
catalog :
16-7101-85
quantity :
500 µg
price :
US 363
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
JES5-16E3
reactivity :
mouse
application :
ELISA, immunocytochemistry, neutralization, flow cytometry
more info or order :
citations: 232
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s3, 4b
Keller E, Dvorina N, Jørgensen T. Spontaneous CD4+ T Cell Activation and Differentiation in Lupus-Prone B6.Nba2 Mice Is IFNAR-Independent. Int J Mol Sci. 2022;23: pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s8c
Zhao D, Kim Y, Jeong S, Greenson J, Chaudhry M, Hoepting M, et al. Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease. J Clin Invest. 2018;128:4970-4979 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Georgiev H, Ravens I, Papadogianni G, Halle S, Malissen B, Loots G, et al. Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches. Front Immunol. 2018;9:714 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4c
Metghalchi S, Vandestienne M, Haddad Y, Esposito B, Dairou J, Tedgui A, et al. Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet. PLoS ONE. 2018;13:e0193737 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 1c
Sutavani R, Phair I, Barker R, McFarlane A, Shpiro N, Lang S, et al. Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases. J Biol Chem. 2018;293:2302-2317 pubmed publisher
  • flow cytometry; mouse; fig 2
Pizzolla A, Oh D, Luong S, Prickett S, Henstridge D, Febbraio M, et al. High Fat Diet Inhibits Dendritic Cell and T Cell Response to Allergens but Does Not Impair Inhalational Respiratory Tolerance. PLoS ONE. 2016;11:e0160407 pubmed publisher
  • flow cytometry; mouse; fig 4, 5
Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, et al. HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT). PLoS Pathog. 2016;12:e1005372 pubmed publisher
  • ELISA; mouse; fig 6
Smith K, Filbey K, Reynolds L, Hewitson J, Harcus Y, Boon L, et al. Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunol. 2016;9:428-43 pubmed publisher
  • flow cytometry; mouse
Redpath S, Van Der Werf N, MacDonald A, Maizels R, Taylor M. Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase. Infect Immun. 2015;83:3881-9 pubmed publisher
  • flow cytometry; mouse; fig 5
Holm J, Sorobetea D, Kiilerich P, Ramayo Caldas Y, Estellé J, Ma T, et al. Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli. PLoS ONE. 2015;10:e0125495 pubmed publisher
  • flow cytometry; mouse; fig s3
Zhang Y, Wu B, Metelli A, Thaxton J, Hong F, Rachidi S, et al. GP96 is a GARP chaperone and controls regulatory T cell functions. J Clin Invest. 2015;125:859-69 pubmed publisher
  • flow cytometry; mouse; fig 4
Berod L, Stüve P, Varela F, Behrends J, Swallow M, Kruse F, et al. Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity. PLoS ONE. 2014;9:e102804 pubmed publisher
  • flow cytometry; mouse
Smolarchuk C, Zhu L, Chan W, Anderson C. T cells generated in the absence of a thoracic thymus fail to establish homeostasis. Eur J Immunol. 2014;44:2263-73 pubmed publisher
  • flow cytometry; mouse; fig 6
Samuelson E, Laird R, Papillion A, Tatum A, Princiotta M, Hayes S. Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice. PLoS ONE. 2014;9:e92054 pubmed publisher
  • flow cytometry; mouse
Chatterjee S, Eby J, Al Khami A, Soloshchenko M, Kang H, Kaur N, et al. A quantitative increase in regulatory T cells controls development of vitiligo. J Invest Dermatol. 2014;134:1285-1294 pubmed publisher
  • immunocytochemistry; mouse
Bodhankar S, Chen Y, Vandenbark A, Murphy S, Offner H. PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1. J Neuroinflammation. 2013;10:111 pubmed publisher
  • flow cytometry; mouse; fig s3
Barron L, Smith A, El Kasmi K, Qualls J, Huang X, Cheever A, et al. Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS ONE. 2013;8:e61961 pubmed publisher
  • flow cytometry; mouse
Loebbermann J, Schnoeller C, Thornton H, Durant L, Sweeney N, Schuijs M, et al. IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice. PLoS ONE. 2012;7:e32371 pubmed publisher
  • flow cytometry; mouse
Loebbermann J, Thornton H, Durant L, Sparwasser T, Webster K, Sprent J, et al. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol. 2012;5:161-72 pubmed publisher
  • flow cytometry; mouse; fig 2, 3
Lin P, Sun L, Thibodeaux S, Ludwig S, Vadlamudi R, Hurez V, et al. B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses. J Immunol. 2010;185:2747-53 pubmed publisher
  • ELISA; mouse; fig 2b
Nijnik A, Madera L, Ma S, Waldbrook M, Elliott M, Easton D, et al. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol. 2010;184:2539-50 pubmed publisher
  • flow cytometry; mouse
Hamada H, Garcia Hernandez M, Reome J, Misra S, Strutt T, McKinstry K, et al. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol. 2009;182:3469-81 pubmed publisher
  • flow cytometry; mouse; fig 7
Ribeiro de Almeida C, Heath H, Krpic S, Dingjan G, van Hamburg J, Bergen I, et al. Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression. J Immunol. 2009;182:999-1010 pubmed
  • flow cytometry; mouse
Wanasen N, Xin L, Soong L. Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection. Int J Parasitol. 2008;38:417-29 pubmed
Liu C, Guo S, Liu R, Guo M, Wang Q, Chai Z, et al. Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis. Neural Regen Res. 2024;19:671-679 pubmed publisher
Zhu K, Wang Y, Sarlus H, Geng K, Nutma E, Sun J, et al. Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation. EMBO Rep. 2022;23:e54499 pubmed publisher
Ma S, Patel S, Abe Y, Chen N, Patel P, Cho B, et al. RORγt phosphorylation protects against T cell-mediated inflammation. Cell Rep. 2022;38:110520 pubmed publisher
Medina Buelvas D, Rodr xed guez Sosa M, Vega L. Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi. Pathogens. 2021;10: pubmed publisher
Lin C, Chen M, Lin L, Christian D, Min B, Hunter C, et al. Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes. J Exp Med. 2021;218: pubmed publisher
Tong L, Hao H, Zhang Z, Lv Y, Liang X, Liu Q, et al. Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota. Theranostics. 2021;11:8570-8586 pubmed publisher
Vernet R, Charrier E, Cosset E, Fi xe8 vre S, Tomasello U, Grogg J, et al. Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model. Vaccines (Basel). 2021;9: pubmed publisher
Chen J, Ding Y, Huang F, Lan R, Wang Z, Huang W, et al. Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells. Oncol Lett. 2021;21:409 pubmed publisher
Kedzierska A, Lorek D, Slawek A, Chelmonska Soyta A. Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings. Sci Rep. 2020;10:10531 pubmed publisher
Ni G, Wang Y, Good D, Yuan J, Pan X, Wei J, et al. The Dosage of the Derivative of Clostridium Ghonii (DCG) Spores Dictates Whether an IFNγ/IL-9 or a Strong IFNγ Response Is Elicited in TC-1 Tumour Bearing Mice. Biomed Res Int. 2019;2019:1395138 pubmed publisher
Kim J, Kim S, Park J, Hwang S, Choi J, Jung K, et al. Metformin improves salivary gland inflammation and hypofunction in murine Sjögren's syndrome. Arthritis Res Ther. 2019;21:136 pubmed publisher
Düsedau H, Kleveman J, Figueiredo C, Biswas A, Steffen J, Kliche S, et al. p75NTR regulates brain mononuclear cell function and neuronal structure in Toxoplasma infection-induced neuroinflammation. Glia. 2019;67:193-211 pubmed publisher
Crosby F, Lundgren A, Hoffman C, Pascual D, Barbet A. VirB10 vaccination for protection against Anaplasma phagocytophilum. BMC Microbiol. 2018;18:217 pubmed publisher
Lauron E, Yang L, Harvey I, Sojka D, Williams G, Paley M, et al. Viral MHCI inhibition evades tissue-resident memory T cell formation and responses. J Exp Med. 2019;216:117-132 pubmed publisher
Karrich J, Romera Hernandez M, Papazian N, Veenbergen S, Cornelissen F, Aparicio Domingo P, et al. Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells. Eur J Immunol. 2019;49:290-301 pubmed publisher
Pan W, Xu H, Hao W, Sun F, Qin Y, Hao S, et al. The excretory-secretory products of Echinococcus granulosus protoscoleces stimulated IL-10 production in B cells via TLR-2 signaling. BMC Immunol. 2018;19:29 pubmed publisher
van Nieuwenhuijze A, Burton O, Lemaitre P, Denton A, Cascalho A, Goodchild R, et al. Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations. Front Immunol. 2018;9:2234 pubmed publisher
Brajic A, Franckaert D, Burton O, Bornschein S, Calvanese A, Demeyer S, et al. The Long Non-coding RNA Flatr Anticipates Foxp3 Expression in Regulatory T Cells. Front Immunol. 2018;9:1989 pubmed publisher
Ogawa C, Bankoti R, Nguyen T, Hassanzadeh Kiabi N, Nadeau S, Porritt R, et al. Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells. Cell Rep. 2018;25:19-28.e5 pubmed publisher
Giles D, Duncker P, Wilkinson N, Washnock Schmid J, Segal B. CNS-resident classical DCs play a critical role in CNS autoimmune disease. J Clin Invest. 2018;128:5322-5334 pubmed publisher
Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt F, Liniany L, Knight D, et al. PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells. Immunity. 2018;49:247-263.e7 pubmed publisher
Kobiyama K, Vassallo M, Mitzi J, Winkels H, Pei H, Kimura T, et al. A clinically applicable adjuvant for an atherosclerosis vaccine in mice. Eur J Immunol. 2018;48:1580-1587 pubmed publisher
Tanaka S, Pfleger C, Lai J, Roan F, Sun S, Ziegler S. KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners. Cell Rep. 2018;23:796-807 pubmed publisher
Swafford D, Shanmugam A, Ranganathan P, Hussein M, Koni P, Prasad P, et al. Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon. J Immunol. 2018;200:3259-3268 pubmed publisher
Rodriguez Cetina Biefer H, Heinbokel T, Uehara H, Camacho V, Minami K, Nian Y, et al. Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation. J Allergy Clin Immunol. 2018;142:1894-1908.e7 pubmed publisher
Xu M, Pokrovskii M, Ding Y, Yi R, Au C, Harrison O, et al. c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont. Nature. 2018;554:373-377 pubmed publisher
Ranganathan P, Shanmugam A, Swafford D, Suryawanshi A, Bhattacharjee P, Hussein M, et al. GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis. J Immunol. 2018;200:1781-1789 pubmed publisher
SMITH C, Allard D, Wang Y, Howard J, Montgomery S, Su M. IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4+ T Cell Migration. J Immunol. 2018;200:1580-1592 pubmed publisher
Goldman N, Lomakova Y, Londregan J, Bucknum A, DePierri K, Somerville J, et al. High macrophage PD-L1 expression not responsible for T cell suppression. Cell Immunol. 2018;324:50-58 pubmed publisher
Xu H, Dahiya S, Wang L, Akimova T, Han R, Zhang T, et al. Utility of IL-2 Complexes in Promoting the Survival of Murine Orthotopic Forelimb Vascularized Composite Allografts. Transplantation. 2018;102:70-78 pubmed publisher
Lee S, Charmoy M, Romano A, Paun A, Chaves M, Cope F, et al. Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment. J Exp Med. 2018;215:357-375 pubmed publisher
Huang S, Wei P, Hwang Verslues W, Kuo W, Jeng Y, Hu C, et al. TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB. EMBO Mol Med. 2017;9:1660-1680 pubmed publisher
Ono Y, Pérez Gutiérrez A, Nakao T, Dai H, Camirand G, Yoshida O, et al. Graft-infiltrating PD-L1hi cross-dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance. Hepatology. 2018;67:1499-1515 pubmed publisher
Ni G, Liao Z, Chen S, Wang T, Yuan J, Pan X, et al. Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice. BMC Immunol. 2017;18:40 pubmed publisher
Vicetti Miguel R, Quispe Calla N, Dixon D, Foster R, Gambotto A, Pavelko S, et al. IL-4-secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage. Proc Natl Acad Sci U S A. 2017;114:E6892-E6901 pubmed publisher
Nadya N, Tezuka H, Ohteki T, Matsuda S, Azuma M, Nagai S. PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells. Immunology. 2017;152:507-516 pubmed publisher
Olson M, Ulrich B, Hummel S, Khan I, Meuris B, Cherukuri Y, et al. Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production. J Immunol. 2017;198:4352-4359 pubmed publisher
Chien C, Yu H, Chen S, Chiang B. Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells. Sci Rep. 2017;7:46348 pubmed publisher
Barrett J, Henry R, Villapol S, Stoica B, Kumar A, Burns M, et al. NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury. J Neuroinflammation. 2017;14:65 pubmed publisher
Goldman N, Valiuskyte K, Londregan J, Swider A, Somerville J, Riggs J. Macrophage regulation of B cell proliferation. Cell Immunol. 2017;314:54-62 pubmed publisher
Conaway E, de Oliveira D, McInnis C, Snapper S, Horwitz B. Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol. 2017;198:2906-2915 pubmed publisher
Cruz L, Hashemifar S, Wu C, Cho S, Nguyen D, Lin L, et al. Excessive expression of miR-27 impairs Treg-mediated immunological tolerance. J Clin Invest. 2017;127:530-542 pubmed publisher
Tahiri H, Omri S, Yang C, Duhamel F, Samarani S, Ahmad A, et al. Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization. Sci Rep. 2016;6:37391 pubmed publisher
Alrefai H, Muhammad K, Rudolf R, Pham D, Klein Hessling S, Patra A, et al. NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells. Nat Commun. 2016;7:11724 pubmed publisher
Tian Y, Kuo C, Akbari O, Ou J. Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission. Immunity. 2016;44:1204-14 pubmed publisher
Singh S, Vedi S, Samrat S, Li W, Kumar R, Agrawal B. Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines. PLoS ONE. 2016;11:e0146404 pubmed publisher
Manlove L, Berquam Vrieze K, Pauken K, Williams R, Jenkins M, Farrar M. Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells. J Immunol. 2015;195:4028-37 pubmed publisher
Roberts R, Eitas T, Byrne J, Johnson B, Short P, McKinnon K, et al. Towards programming immune tolerance through geometric manipulation of phosphatidylserine. Biomaterials. 2015;72:1-10 pubmed publisher
Kratochvill F, Gratz N, Qualls J, Van De Velde L, Chi H, Kovarik P, et al. Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner. Cancer Res. 2015;75:3054-64 pubmed publisher
Deppisch N, Ruf P, Eissler N, Neff F, Buhmann R, Lindhofer H, et al. Efficacy and Tolerability of a GD2-Directed Trifunctional Bispecific Antibody in a Preclinical Model: Subcutaneous Administration Is Superior to Intravenous Delivery. Mol Cancer Ther. 2015;14:1877-83 pubmed publisher
Song N, Gao L, Qiu H, Huang C, Cheng H, Zhou H, et al. Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant. Int J Mol Med. 2015;36:139-49 pubmed publisher
Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo M, et al. Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation. J Immunol. 2015;194:3295-304 pubmed publisher
Kasahara K, Sasaki N, Yamashita T, Kita T, Yodoi K, Sasaki Y, et al. CD3 antibody and IL-2 complex combination therapy inhibits atherosclerosis by augmenting a regulatory immune response. J Am Heart Assoc. 2014;3:e000719 pubmed publisher
Bakhru P, Sirisaengtaksin N, Soudani E, Mukherjee S, Khan A, Jagannath C. BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cell Immunol. 2014;287:53-61 pubmed publisher
Sánchez Vallecillo M, Ullio Gamboa G, Palma S, Harman M, Chiodetti A, Moron G, et al. Adjuvant activity of CpG-ODN formulated as a liquid crystal. Biomaterials. 2014;35:2529-42 pubmed publisher
Bodhankar S, Chen Y, Vandenbark A, Murphy S, Offner H. Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice. Metab Brain Dis. 2014;29:59-73 pubmed publisher
Wei H, Zhao L, Li W, Fan K, Qian W, Hou S, et al. Combinatorial PD-1 blockade and CD137 activation has therapeutic efficacy in murine cancer models and synergizes with cisplatin. PLoS ONE. 2013;8:e84927 pubmed publisher
Kim J, Stott R, Soohoo J, Lee K, Zhao G, Yeh H, et al. Elevated levels of interferon-? production by memory T cells do not promote transplant tolerance resistance in aged recipients. PLoS ONE. 2013;8:e82856 pubmed publisher
Gower R, Boehler R, Azarin S, Ricci C, Leonard J, Shea L. Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression. Biomaterials. 2014;35:2024-31 pubmed publisher
Dey M, Chang A, Wainwright D, Ahmed A, Han Y, Balyasnikova I, et al. Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model. J Neuroimmunol. 2014;266:33-42 pubmed publisher
Holan V, Zajicova A, Javorkova E, Trosan P, Chudícková M, Pavlikova M, et al. Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells. Immunology. 2014;141:577-86 pubmed publisher
Wang S, Wu B, Xue J, Wang M, Chen R, Wang B. Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge. Hum Vaccin Immunother. 2014;10:461-8 pubmed publisher
Obregón Henao A, Henao Tamayo M, Orme I, Ordway D. Gr1(int)CD11b+ myeloid-derived suppressor cells in Mycobacterium tuberculosis infection. PLoS ONE. 2013;8:e80669 pubmed publisher
Kling J, Mack M, Korner H. The absence of CCR7 results in dysregulated monocyte migration and immunosuppression facilitating chronic cutaneous leishmaniasis. PLoS ONE. 2013;8:e79098 pubmed publisher
Banerjee A, Wang J, Bodhankar S, Vandenbark A, Murphy S, Offner H. Phenotypic changes in immune cell subsets reflect increased infarct volume in male vs. female mice. Transl Stroke Res. 2013;4:554-63 pubmed
Lee H, Jang M, Kim J, Hong C, Lee E, Jeun E, et al. Ulmus davidiana var. japonica Nakai upregulates eosinophils and suppresses Th1 and Th17 cells in the small intestine. PLoS ONE. 2013;8:e76716 pubmed publisher
Corsetti P, de Almeida L, Carvalho N, Azevedo V, Silva T, Teixeira H, et al. Lack of endogenous IL-10 enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in mice. PLoS ONE. 2013;8:e74729 pubmed publisher
Gangaplara A, Massilamany C, Steffen D, Reddy J. Mimicry epitope from Ehrlichia canis for interphotoreceptor retinoid-binding protein 201-216 prevents autoimmune uveoretinitis by acting as altered peptide ligand. J Neuroimmunol. 2013;263:98-107 pubmed publisher
Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, et al. Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells. J Immunol. 2013;191:3614-23 pubmed publisher
Maseda D, Candando K, Smith S, Kalampokis I, Weaver C, Plevy S, et al. Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-?+CD4+ T cell numbers during colitis development in mice. J Immunol. 2013;191:2780-2795 pubmed publisher
Mineo S, Niikura M, Inoue S, Kuroda M, Kobayashi F. Development of severe pathology in immunized pregnant mice challenged with lethal malaria parasites. Infect Immun. 2013;81:3865-71 pubmed publisher
Leepiyasakulchai C, Taher C, Chuquimia O, Mazurek J, Söderberg Naucler C, Fernández C, et al. Infection rate and tissue localization of murine IL-12p40-producing monocyte-derived CD103(+) lung dendritic cells during pulmonary tuberculosis. PLoS ONE. 2013;8:e69287 pubmed publisher
de Kouchkovsky D, Esensten J, Rosenthal W, Morar M, Bluestone J, Jeker L. microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis. J Immunol. 2013;191:1594-605 pubmed publisher
Ishii H, Tanabe S, Ueno M, Kubo T, Kayama H, Serada S, et al. ifn-?-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Cell Death Dis. 2013;4:e710 pubmed publisher
Zhang R, Li Q, Chuang P, Lu G, Liu R, Yang J, et al. Regulation of pathogenic Th17 cell differentiation by IL-10 in the development of glomerulonephritis. Am J Pathol. 2013;183:402-12 pubmed publisher
Hu Z, Zhang W, Usherwood E. Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect. J Immunol. 2013;191:312-22 pubmed publisher
Bae J, Koo J, Kim S, Park T, Kim M. Ginsenoside Rp1 Exerts Anti-inflammatory Effects via Activation of Dendritic Cells and Regulatory T Cells. J Ginseng Res. 2012;36:375-82 pubmed publisher
Thomas D, Wong F, Zaccone P, Green E, Wallberg M. Protection of islet grafts through transforming growth factor-?-induced tolerogenic dendritic cells. Diabetes. 2013;62:3132-42 pubmed publisher
Wan X, Guloglu F, Vanmorlan A, Rowland L, Zaghouani S, Cascio J, et al. Recovery from overt type 1 diabetes ensues when immune tolerance and ?-cell formation are coupled with regeneration of endothelial cells in the pancreatic islets. Diabetes. 2013;62:2879-89 pubmed publisher
Kalli F, Machiorlatti R, Battaglia F, Parodi A, Conteduca G, Ferrera F, et al. Comparative analysis of cancer vaccine settings for the selection of an effective protocol in mice. J Transl Med. 2013;11:120 pubmed publisher
Bodhankar S, Chen Y, Vandenbark A, Murphy S, Offner H. IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke. Metab Brain Dis. 2013;28:375-86 pubmed publisher
Yanaba K, Kamata M, Ishiura N, Shibata S, Asano Y, Tada Y, et al. Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. J Leukoc Biol. 2013;94:563-73 pubmed publisher
Natividad K, Junankar S, Mohd Redzwan N, Nair R, Wirasinha R, King C, et al. Interleukin-27 signaling promotes immunity against endogenously arising murine tumors. PLoS ONE. 2013;8:e57469 pubmed publisher
Ferreira I, Smyth D, Gaze S, Aziz A, Giacomin P, Ruyssers N, et al. Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitis. Infect Immun. 2013;81:2104-11 pubmed publisher
Gahring L, Enioutina E, Myers E, Spangrude G, Efimova O, Kelley T, et al. Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage. PLoS ONE. 2013;8:e57481 pubmed publisher
Schreiner J, Kretschmer D, Klenk J, Otto M, Bühring H, Stevanovic S, et al. Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in vitro priming of regulatory T cells. J Immunol. 2013;190:3417-26 pubmed publisher
Breser M, Motrich R, Sanchez L, Mackern Oberti J, Rivero V. Expression of CXCR3 on specific T cells is essential for homing to the prostate gland in an experimental model of chronic prostatitis/chronic pelvic pain syndrome. J Immunol. 2013;190:3121-33 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
IL-10 Monoclonal Antibody (JES5-16E3), Functional Grade, eBioscience
Catalog # :
16-7101-85
Quantity :
500 µg
Price :
US 363
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Functional Assay: Assay-Dependent, Immunostaining: 1-4 µg/mL, Neutralization: Assay-Dependent
Species :
Mouse
Clone :
JES5-16E3
Isotype :
IgG2b, kappa
Storage :
4° C
Description :
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
Format :
Liquid
Applications w/Dilutions :
Functional Assay: Assay-Dependent, Immunostaining: 1-4 µg/mL, Neutralization: Assay-Dependent
Aliases :
CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA