CCL2 (MCP-1) Monoclonal Antibody (2H5), Functional Grade, eBioscience | Invitrogen 16-7096-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CCL2 (MCP-1) Monoclonal Antibody (2H5), Functional Grade, eBioscience

catalog :

16-7096-81

quantity :

50 µg

price :

US 117

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

2H5

reactivity :

human, mouse, rat

application :

ELISA, neutralization

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
ELISA; human; fig 1b ELISA; mouse; fig 2b	Nijnik A, Madera L, Ma S, Waldbrook M, Elliott M, Easton D, et al. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol. 2010;184:2539-50 pubmed publisher
	Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez Navarro A, Eivers L, et al. Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity. 2023;56:2325-2341.e15 pubmed publisher
	Zheng C, Sui B, Zhang X, Hu J, Chen J, Liu J, et al. Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes. J Extracell Vesicles. 2021;10:e12109 pubmed publisher
	Hong L, Wang Q, Chen M, Shi J, Guo Y, Liu S, et al. Mas receptor activation attenuates allergic airway inflammation via inhibiting JNK/CCL2-induced macrophage recruitment. Biomed Pharmacother. 2021;137:111365 pubmed publisher
	Berry M, Mathews R, Ferdinand J, Jing C, Loudon K, Wlodek E, et al. Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone. Cell. 2017;170:860-874.e19 pubmed publisher
	Bleau C, Filliol A, Samson M, Lamontagne L. Brain Invasion by Mouse Hepatitis Virus Depends on Impairment of Tight Junctions and Beta Interferon Production in Brain Microvascular Endothelial Cells. J Virol. 2015;89:9896-908 pubmed publisher
	Shen C, Lie P, Miao T, Yu M, Lu Q, Feng T, et al. Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis. Mol Med Rep. 2015;12:20-30 pubmed publisher
	Nijnik A, Pistolic J, Cho P, Filewod N, Falsafi R, Ramin A, et al. The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells. J Leukoc Biol. 2012;91:599-607 pubmed publisher
	Lehar J, Krueger A, Avery W, Heilbut A, Johansen L, Price E, et al. Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nat Biotechnol. 2009;27:659-66 pubmed publisher
	Taal M, Chertow G, Rennke H, Gurnani A, Jiang T, Shahsafaei A, et al. Mechanisms underlying renoprotection during renin-angiotensin system blockade. Am J Physiol Renal Physiol. 2001;280:F343-55 pubmed
	Luo Y, Fischer F, Hancock W, Dorf M. Macrophage inflammatory protein-2 and KC induce chemokine production by mouse astrocytes. J Immunol. 2000;165:4015-23 pubmed

product information

Product Type :

Antibody

Product Name :

CCL2 (MCP-1) Monoclonal Antibody (2H5), Functional Grade, eBioscience

Catalog # :

16-7096-81

Quantity :

50 µg

Price :

US 117

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Human, Mouse, Rat

Applications :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Human, Mouse, Rat

Clone :

2H5

Isotype :

IgG

Storage :

4° C

Description :

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Format :

Liquid

Applications w/Dilutions :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

Acidic seminal fluid protein; AI323594; C-C motif chemokine 2; C-C motif chemokine ligand 2; Ccl2; chemokine (C-C motif) ligand 2; GDCF-2; HC11; H-MCP-1; HSMCR30; immediate-early serum-responsive JE protein; immediate-early serum-responsive protein JE; Je; MCAF; Mcp1; MCP-1; MCP1A; MCP-1A; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; monocyte chemotactic protein 1A; Monocyte secretory protein JE; monocyte-chemoattractant protein-1 precursor; platelet-derived growth factor-inducible protein JE; RP23-350G1.3; SCYA2; Sigje; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible gene JE; small-inducible cytokine A2; SMC-CF

more info or order :

Invitrogen product webpage