IL-5 Monoclonal Antibody (TRFK5), Functional Grade, eBioscience | Invitrogen 16-7052-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-5 Monoclonal Antibody (TRFK5), Functional Grade, eBioscience

catalog :

16-7052-050

quantity :

50 mg

price :

US 13750

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

TRFK5

reactivity :

human, mouse

application :

immunohistochemistry, neutralization

citations: 10

Reference
Chetty A, Darby M, Vornewald P, Martín Alonso M, Filz A, Ritter M, et al. Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection. Cell Host Microbe. 2021;29:579-593.e5 pubmed publisher
Rogers M, Lamens K, Shafagati N, Johnson M, Oury T, Joyce S, et al. CD4+ Regulatory T Cells Exert Differential Functions during Early and Late Stages of the Immune Response to Respiratory Viruses. J Immunol. 2018;201:1253-1266 pubmed publisher
Daenthanasanmak A, Wu Y, Iamsawat S, Nguyen H, Bastian D, Zhang M, et al. PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity. J Clin Invest. 2018;128:2787-2801 pubmed publisher
Lorentsen K, Cho J, Luo X, Zuniga A, Urban J, Zhou L, et al. Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma. Nat Commun. 2018;9:1679 pubmed publisher
Neal L, Qiu Y, Chung J, Xing E, Cho W, Malachowski A, et al. T Cell-Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity during Cryptococcus neoformans Infection. J Immunol. 2017;199:643-655 pubmed publisher
Wang H, Qian L, Zhao Y, Mengarelli J, Adrianto I, Montgomery C, et al. Downregulation of E Protein Activity Augments an ILC2 Differentiation Program in the Thymus. J Immunol. 2017;198:3149-3156 pubmed publisher
Oh J, Oh D, Jung H, Lee H. A mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract. Proc Natl Acad Sci U S A. 2017;114:E1188-E1195 pubmed publisher
Jackson Jones L, Duncan S, Magalhaes M, Campbell S, Maizels R, McSorley H, et al. Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation. Nat Commun. 2016;7:12651 pubmed publisher
Luchansky M, Bailey R. Rapid, multiparameter profiling of cellular secretion using silicon photonic microring resonator arrays. J Am Chem Soc. 2011;133:20500-6 pubmed publisher
Lu Z, Ghazizadeh S. Loss of transgene following ex vivo gene transfer is associated with a dominant Th2 response: implications for cutaneous gene therapy. Mol Ther. 2007;15:954-61 pubmed

product information

Product Type :

Antibody

Product Name :

IL-5 Monoclonal Antibody (TRFK5), Functional Grade, eBioscience

Catalog # :

16-7052-050

Quantity :

50 mg

Price :

US 13750

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse

Applications :

ELISA: 0.06 µg/mL, Functional Assay: Assay-Dependent, Immunohistochemistry: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Human, Mouse

Clone :

TRFK5

Isotype :

IgG1

Storage :

4° C

Description :

IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.06 µg/mL, Functional Assay: Assay-Dependent, Immunohistochemistry: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

B-cell differentiation factor I; B-cell growth factor II; BCGF-II; colony-stimulating factor, eosinophil; cytotoxic T-lymphocyte inducer; EDF; Eosinophil differentiation factor; IL5; IL-5; ILN; Interleukin; Interleukin 5; Interleukin 5 (colony-stimulating factor eosinophil); Interleukin 5 (colony-stimulating factor, eosinophil); Interleukin5; interleukin-5; T-cell replacing factor; TRF