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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-4 Monoclonal Antibody (MP4-25D2), Functional Grade, eBioscience
catalog :
16-7048-85
quantity :
500 µg
price :
US 382
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
MP4-25D2
reactivity :
human
application :
neutralization, flow cytometry, blocking or activating experiments
more info or order :
Invitrogen product webpage
citations: 38
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; 10 ug/ml
Deng N, Weaver J, Mosmann T. Cytokine diversity in the Th1-dominated human anti-influenza response caused by variable cytokine expression by Th1 cells, and a minor population of uncommitted IL-2+IFN?- Thpp cells. PLoS ONE. 2014;9:e95986 pubmed publisher
  • flow cytometry; human
Gironi M, Saresella M, Rovaris M, Vaghi M, Nemni R, Clerici M, et al. A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis. Immun Ageing. 2013;10:1 pubmed publisher
  • flow cytometry; human; fig 1C
Yamada H, Nakashima Y, Okazaki K, Mawatari T, Fukushi J, Kaibara N, et al. Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis. Ann Rheum Dis. 2008;67:1299-304 pubmed
  • blocking or activating experiments; human; 5 ug/ml
De Fanis U, Mori F, Kurnat R, Lee W, Bova M, Adkinson N, et al. GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells. Blood. 2007;109:4343-50 pubmed
Wongchang T, Pluangnooch P, Hongeng S, Wongkajornsilp A, Thumkeo D, Soontrapa K. Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response. Sci Rep. 2023;13:7058 pubmed publisher
Qian Y, Arellano G, Ifergan I, Lin J, Snowden C, Kim T, et al. ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis. Cell Rep. 2021;36:109602 pubmed publisher
Han K, Singh K, Rodman M, Hassanzadeh S, Wu K, Nguyen A, et al. Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness. Nat Metab. 2021;3:318-326 pubmed publisher
Sun B, Chang H, Salinger A, Tomita B, Bawadekar M, Holmes C, et al. Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination. JCI Insight. 2019;4: pubmed publisher
Doh K, Kim B, Kim K, Chung B, Yang C. Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression. BMC Complement Altern Med. 2019;19:54 pubmed publisher
Wu R, Zeng J, Yuan J, Deng X, Huang Y, Chen L, et al. MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation. J Clin Invest. 2018;128:2551-2568 pubmed publisher
Anuradha R, Munisankar S, Bhootra Y, Dolla C, Kumaran P, Nutman T, et al. Modulation of CD4+ and CD8+ T Cell Function and Cytokine Responses in Strongyloides stercoralis Infection by Interleukin-27 (IL-27) and IL-37. Infect Immun. 2017;85: pubmed publisher
Fan H, Li L, Zhang Y, Yang J, Li M, Zeng F, et al. PKC? in prostate cancer cells represses the recruitment and M2 polarization of macrophages in the prostate cancer microenvironment. Tumour Biol. 2017;39:1010428317701442 pubmed publisher
Takahashi H, Tsuboi H, Asashima H, Hirota T, Kondo Y, Moriyama M, et al. cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjögren's syndrome. Clin Exp Immunol. 2017;190:96-109 pubmed publisher
Blom L, Poulsen L. In vitro Th1 and Th2 cell polarization is severely influenced by the initial ratio of naïve and memory CD4+ T cells. J Immunol Methods. 2013;397:55-60 pubmed publisher
Asgari E, Le Friec G, Yamamoto H, Perucha E, Sacks S, Köhl J, et al. C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. Blood. 2013;122:3473-81 pubmed publisher
Yan R, Zhong W, Zhu Y, Zhang X. Trichosanthin-stimulated dendritic cells induce a type 2 helper T lymphocyte response through the OX40 ligand. J Investig Allergol Clin Immunol. 2012;22:491-500 pubmed
Blom L, Poulsen L. IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures. J Immunol. 2012;189:4331-7 pubmed publisher
Chung B, Kim K, Kim B, Piao S, Lim S, Choi B, et al. Dysregulation of Th17 cells during the early post-transplant period in patients under calcineurin inhibitor based immunosuppression. PLoS ONE. 2012;7:e42011 pubmed publisher
Gaspar Ramírez O, Pérez Vázquez F, Pruneda Álvarez L, Orta García S, Gonzalez Amaro R, Pérez Maldonado I. Effect of polychlorinated biphenyls 118 and 153 on Th1/Th2 cells differentiation. Immunopharmacol Immunotoxicol. 2012;34:627-32 pubmed publisher
Hansmann L, Schmidl C, Kett J, Steger L, Andreesen R, Hoffmann P, et al. Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression. J Immunol. 2012;188:1275-82 pubmed publisher
Simhadri V, Mariano J, Zhou Q, DeBell K, Borrego F. Differential expression of CD300a/c on human TH1 and TH17 cells. BMC Immunol. 2011;12:62 pubmed publisher
Divekar A, Khanna D, Abtin F, Maranian P, Saggar R, Saggar R, et al. Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4(+) T cells in the broncho-alveolar lavage of patients with systemic sclerosis. Clin Immunol. 2011;141:293-303 pubmed publisher
Chung B, Kim K, Sun I, Choi S, Park H, Jeon E, et al. Increased interleukin-17 producing effector memory T cells in the end-stage renal disease patients. Immunol Lett. 2012;141:181-9 pubmed publisher
Blom L, Poulsen B, Jensen B, Hansen A, Poulsen L. IL-33 induces IL-9 production in human CD4+ T cells and basophils. PLoS ONE. 2011;6:e21695 pubmed publisher
Tjin E, Konijnenberg D, Krebbers G, Mallo H, Drijfhout J, Franken K, et al. T-cell immune function in tumor, skin, and peripheral blood of advanced stage melanoma patients: implications for immunotherapy. Clin Cancer Res. 2011;17:5736-47 pubmed publisher
Kalache S, Dinavahi R, Pinney S, Mehrotra A, Cunningham M, Heeger P. Anticardiac myosin immunity and chronic allograft vasculopathy in heart transplant recipients. J Immunol. 2011;187:1023-30 pubmed publisher
Stephens G, Swerdlow B, Benjamin E, Coyle A, Humbles A, Kolbeck R, et al. IL-9 is a Th17-derived cytokine that limits pathogenic activity in organ-specific autoimmune disease. Eur J Immunol. 2011;41:952-62 pubmed publisher
James E, Van Haren S, Ettinger R, Fijnvandraat K, Liberman J, Kwok W, et al. T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site. J Thromb Haemost. 2011;9:689-99 pubmed publisher
Saresella M, Calabrese E, Marventano I, Piancone F, Gatti A, Alberoni M, et al. Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer's disease. Brain Behav Immun. 2011;25:539-47 pubmed publisher
Yadav M, Liebau E, Haldar C, Rathaur S. Identification of major antigenic peptide of filarial glutathione-S-transferase. Vaccine. 2011;29:1297-303 pubmed publisher
Narayanan S, Silva R, Peruzzi G, Alvarez Y, Simhadri V, DeBell K, et al. Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. PLoS ONE. 2010;5:e10636 pubmed publisher
Colin E, Asmawidjaja P, van Hamburg J, Mus A, van Driel M, Hazes J, et al. 1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum. 2010;62:132-42 pubmed publisher
Wang J, Huizinga T, Toes R. De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid. J Immunol. 2009;183:4119-26 pubmed publisher
Jain P, Manuel S, Khan Z, Ahuja J, Quann K, Wigdahl B. DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells. J Virol. 2009;83:10908-21 pubmed publisher
Kaminuma O, Kitamura F, Miyatake S, Yamaoka K, Miyoshi H, Inokuma S, et al. T-box 21 transcription factor is responsible for distorted T(H)2 differentiation in human peripheral CD4+ T cells. J Allergy Clin Immunol. 2009;123:813-23.e3 pubmed publisher
Suzukawa M, Iikura M, Koketsu R, Nagase H, Tamura C, Komiya A, et al. An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor. J Immunol. 2008;181:5981-9 pubmed
Hartigan O Connor D, Abel K, McCune J. Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med. 2007;204:2679-92 pubmed
Soler D, Chapman T, Poisson L, Wang L, Cote Sierra J, Ryan M, et al. CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes. J Immunol. 2006;177:6940-51 pubmed
product information
Product Type :
Antibody
Product Name :
IL-4 Monoclonal Antibody (MP4-25D2), Functional Grade, eBioscience
Catalog # :
16-7048-85
Quantity :
500 µg
Price :
US 382
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Human
Applications :
Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Species :
Human
Clone :
MP4-25D2
Isotype :
IgG1, kappa
Storage :
4° C
Description :
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
Format :
Liquid
Applications w/Dilutions :
Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Aliases :
B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA