IL-2 Monoclonal Antibody (AB12-3G4), Functional Grade, eBioscience | Invitrogen 16-7027-85 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-2 Monoclonal Antibody (AB12-3G4), Functional Grade, eBioscience

catalog :

16-7027-85

quantity :

500 µg

price :

US 381.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AB12-3G4

reactivity :

human

application :

neutralization, flow cytometry

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 1a	Dimitrova M, Zenarruzabeitia O, Borrego F, Simhadri V. CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition. Sci Rep. 2016;6:23942 pubmed publisher
	Abrahimi P, Qin L, Chang W, Bothwell A, Tellides G, Saltzman W, et al. Blocking MHC class II on human endothelium mitigates acute rejection. JCI Insight. 2016;1: pubmed
	Chen Q, Kim Y, Laurence A, Punkosdy G, Shevach E. IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo. J Immunol. 2011;186:6329-37 pubmed publisher
	Smith S, Warren G, Thong Y, McCormack J. Suppression of monocyte and neutrophil function by recombinant IL-2. Mediators Inflamm. 1993;2:59-65 pubmed
	Malek T. The main function of IL-2 is to promote the development of T regulatory cells. J Leukoc Biol. 2003;74:961-5 pubmed

product information

Product Type :

Antibody

Product Name :

IL-2 Monoclonal Antibody (AB12-3G4), Functional Grade, eBioscience

Catalog # :

16-7027-85

Quantity :

500 µg

Price :

US 381.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Human

Clone :

AB12-3G4

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.

Format :

Liquid

Applications w/Dilutions :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF

more info or order :

Invitrogen product webpage