IL-2 Monoclonal Antibody (JES6-1A12), Functional Grade, eBioscience | Invitrogen 16-7022-95 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-2 Monoclonal Antibody (JES6-1A12), Functional Grade, eBioscience

catalog :

16-7022-95

quantity :

10 mg

price :

US 3210.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

JES6-1A12

reactivity :

human, mouse

application :

ELISA, neutralization, immunoprecipitation, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 30

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse; loading ...; fig s3a	Baens M, Stirparo R, Lampi Y, Verbeke D, Vandepoel R, Cools J, et al. Malt1 self-cleavage is critical for regulatory T cell homeostasis and anti-tumor immunity in mice. Eur J Immunol. 2018;48:1728-1738 pubmed publisher
blocking or activating experiments; human	Hannani D, VÃ©tizou M, Enot D, Rusakiewicz S, Chaput N, Klatzmann D, et al. Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25. Cell Res. 2015;25:208-24 pubmed publisher
blocking or activating experiments; mouse	Amado I, Berges J, Luther R, Mailhé M, Garcia S, Bandeira A, et al. IL-2 coordinates IL-2-producing and regulatory T cell interplay. J Exp Med. 2013;210:2707-20 pubmed publisher
blocking or activating experiments; mouse	Loebbermann J, Thornton H, Durant L, Sparwasser T, Webster K, Sprent J, et al. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol. 2012;5:161-72 pubmed publisher
ELISA; mouse	Park S, Han Y, Aleyas A, George J, Yoon H, Lee J, et al. Low-dose antigen-experienced CD4+ T cells display reduced clonal expansion but facilitate an effective memory pool in response to secondary exposure. Immunology. 2008;123:426-37 pubmed
ELISA; mouse; fig 2	Kobie J, Shah P, Yang L, Rebhahn J, Fowell D, Mosmann T. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J Immunol. 2006;177:6780-6 pubmed
	O Connor E, Muñoz Wolf N, León G, Lavelle E, Mills K, Walsh P, et al. UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation. PLoS ONE. 2020;15:e0239713 pubmed publisher
	Park G, Lee G, Kim S, Hong H, Park J, Cho J, et al. Deletion Timing of Cic Alleles during Hematopoiesis Determines the Degree of Peripheral CD4+ T Cell Activation and Proliferation. Immune Netw. 2020;20:e43 pubmed publisher
	Köhler C, Smole U, Kratzer B, Trapin D, Schmetterer K, Pickl W. Allergen alters IL-2/αIL-2-based Treg expansion but not tolerance induction in an allergen-specific mouse model. Allergy. 2020;75:1618-1629 pubmed publisher
	Ratnasothy K, Jacob J, Tung S, Boardman D, Lechler R, Sanchez Fueyo A, et al. IL-2 therapy preferentially expands adoptively transferred donor-specific Tregs improving skin allograft survival. Am J Transplant. 2019;19:2092-2100 pubmed publisher
	Mencarelli A, Khameneh H, Fric J, Vacca M, El Daker S, Janela B, et al. Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis. Nat Commun. 2018;9:1102 pubmed publisher
	Carpier J, Zucchetti A, Bataille L, Dogniaux S, Shafaq Zadah M, Bardin S, et al. Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation. J Exp Med. 2018;215:1245-1265 pubmed publisher
	Johnson R, Yu H, Strank N, Karunakaran K, Zhu Y, Brunham R. B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4?13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters. Infect Immun. 2018;86: pubmed publisher
	Park S, Lee S, Lee C, Park G, Hong H, Lee J, et al. Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5. Nat Commun. 2017;8:16037 pubmed publisher
	Karim A, Reba S, Li Q, Boom W, Rojas R. Toll like Receptor 2 engagement on CD4+ T cells promotes TH9 differentiation and function. Eur J Immunol. 2017;47:1513-1524 pubmed publisher
	Whitehouse G, Gray E, Mastoridis S, Merritt E, Kodela E, Yang J, et al. IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors. Proc Natl Acad Sci U S A. 2017;114:7083-7088 pubmed publisher
	Manirarora J, Wei C. Combination Therapy Using IL-2/IL-2 Monoclonal Antibody Complexes, Rapamycin, and Islet Autoantigen Peptides Increases Regulatory T Cell Frequency and Protects against Spontaneous and Induced Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol. 2015;195:5203-14 pubmed publisher
	Weist B, Kurd N, Boussier J, Chan S, Robey E. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol. 2015;16:635-41 pubmed publisher
	Zhang L, Manirarora J, Wei C. Evaluation of immunosuppressive function of regulatory T cells using a novel in vitro cytotoxicity assay. Cell Biosci. 2014;4:51 pubmed publisher
	Roupie V, Pidot S, Einarsdottir T, Van Den Poel C, Jurion F, Stinear T, et al. Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice. PLoS Negl Trop Dis. 2014;8:e2604 pubmed publisher
	Gopinath S, Hotson A, Johns J, Nolan G, Monack D. The systemic immune state of super-shedder mice is characterized by a unique neutrophil-dependent blunting of TH1 responses. PLoS Pathog. 2013;9:e1003408 pubmed publisher
	Wohlfert E, Grainger J, Bouladoux N, Konkel J, Oldenhove G, Ribeiro C, et al. GATA3 controls Foxp3âº regulatory T cell fate during inflammation in mice. J Clin Invest. 2011;121:4503-15 pubmed publisher
	Hamano R, Huang J, Yoshimura T, Oppenheim J, Chen X. TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40. Eur J Immunol. 2011;41:2010-20 pubmed publisher
	Liu R, Zhou Q, La Cava A, Campagnolo D, Van Kaer L, Shi F. Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia. Eur J Immunol. 2010;40:1577-89 pubmed publisher
	Oldenhove G, Bouladoux N, Wohlfert E, Hall J, Chou D, Dos Santos L, et al. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity. 2009;31:772-86 pubmed publisher
	Wallet M, Sen P, Flores R, Wang Y, Yi Z, Huang Y, et al. MerTK is required for apoptotic cell-induced T cell tolerance. J Exp Med. 2008;205:219-32 pubmed publisher
	Anis M, Fulton S, Reba S, Liu Y, Harding C, Boom W. Modulation of pulmonary dendritic cell function during mycobacterial infection. Infect Immun. 2008;76:671-7 pubmed
	Anis M, Fulton S, Reba S, Harding C, Boom W. Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection. Infect Immun. 2007;75:2260-8 pubmed
	Gadola S, Silk J, Jeans A, Illarionov P, Salio M, Besra G, et al. Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases. J Exp Med. 2006;203:2293-303 pubmed
	Muljo S, Ansel K, Kanellopoulou C, Livingston D, Rao A, Rajewsky K. Aberrant T cell differentiation in the absence of Dicer. J Exp Med. 2005;202:261-9 pubmed

product information

Product Type :

Antibody

Product Name :

IL-2 Monoclonal Antibody (JES6-1A12), Functional Grade, eBioscience

Catalog # :

16-7022-95

Quantity :

10 mg

Price :

US 3210.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Functional Assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Immunostaining: 0.250 µg/mL, Neutralization: Assay-Dependent

Species :

Mouse

Clone :

JES6-1A12

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.

Format :

Liquid

Applications w/Dilutions :

Functional Assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Immunostaining: 0.250 µg/mL, Neutralization: Assay-Dependent

Aliases :

aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF

more info or order :

Invitrogen product webpage