This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-2 Monoclonal Antibody (JES6-1A12), Functional Grade, eBioscience
catalog :
16-7022-38
quantity :
5 mg
price :
US 3100.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
JES6-1A12

The same clone is also sold as:
reactivity :
mouse
application :
neutralization, immunoprecipitation
citations: 17
Reference
O Connor E, Muñoz Wolf N, León G, Lavelle E, Mills K, Walsh P, et al. UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation. PLoS ONE. 2020;15:e0239713 pubmed publisher
Park G, Lee G, Kim S, Hong H, Park J, Cho J, et al. Deletion Timing of Cic Alleles during Hematopoiesis Determines the Degree of Peripheral CD4+ T Cell Activation and Proliferation. Immune Netw. 2020;20:e43 pubmed publisher
Ratnasothy K, Jacob J, Tung S, Boardman D, Lechler R, Sanchez Fueyo A, et al. IL-2 therapy preferentially expands adoptively transferred donor-specific Tregs improving skin allograft survival. Am J Transplant. 2019;19:2092-2100 pubmed publisher
Liu B, Salgado O, Singh S, Hippen K, Maynard J, Burlingame A, et al. The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation. Nat Commun. 2019;10:354 pubmed publisher
Kälin S, Becker M, Ott V, Serr I, Hosp F, Mollah M, et al. A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. Cell Metab. 2017;26:475-492.e7 pubmed publisher
Park S, Lee S, Lee C, Park G, Hong H, Lee J, et al. Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5. Nat Commun. 2017;8:16037 pubmed publisher
Manirarora J, Wei C. Combination Therapy Using IL-2/IL-2 Monoclonal Antibody Complexes, Rapamycin, and Islet Autoantigen Peptides Increases Regulatory T Cell Frequency and Protects against Spontaneous and Induced Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol. 2015;195:5203-14 pubmed publisher
Weist B, Kurd N, Boussier J, Chan S, Robey E. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol. 2015;16:635-41 pubmed publisher
Zhang L, Manirarora J, Wei C. Evaluation of immunosuppressive function of regulatory T cells using a novel in vitro cytotoxicity assay. Cell Biosci. 2014;4:51 pubmed publisher
Roupie V, Pidot S, Einarsdottir T, Van Den Poel C, Jurion F, Stinear T, et al. Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice. PLoS Negl Trop Dis. 2014;8:e2604 pubmed publisher
Gopinath S, Hotson A, Johns J, Nolan G, Monack D. The systemic immune state of super-shedder mice is characterized by a unique neutrophil-dependent blunting of TH1 responses. PLoS Pathog. 2013;9:e1003408 pubmed publisher
Wohlfert E, Grainger J, Bouladoux N, Konkel J, Oldenhove G, Ribeiro C, et al. GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice. J Clin Invest. 2011;121:4503-15 pubmed publisher
Hamano R, Huang J, Yoshimura T, Oppenheim J, Chen X. TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40. Eur J Immunol. 2011;41:2010-20 pubmed publisher
Liu R, Zhou Q, La Cava A, Campagnolo D, Van Kaer L, Shi F. Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia. Eur J Immunol. 2010;40:1577-89 pubmed publisher
Oldenhove G, Bouladoux N, Wohlfert E, Hall J, Chou D, Dos Santos L, et al. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity. 2009;31:772-86 pubmed publisher
Anis M, Fulton S, Reba S, Liu Y, Harding C, Boom W. Modulation of pulmonary dendritic cell function during mycobacterial infection. Infect Immun. 2008;76:671-7 pubmed
Anis M, Fulton S, Reba S, Harding C, Boom W. Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection. Infect Immun. 2007;75:2260-8 pubmed
product information
Product Type :
Antibody
Product Name :
IL-2 Monoclonal Antibody (JES6-1A12), Functional Grade, eBioscience
Catalog # :
16-7022-38
Quantity :
5 mg
Price :
US 3100.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Functional Assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Immunostaining: 0.250 ug/mL, Neutralization: Assay-Dependent
Species :
Mouse
Clone :
JES6-1A12
Isotype :
IgG2a, kappa
Storage :
4 C
Description :
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
Format :
Liquid
Applications w/Dilutions :
Functional Assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Immunostaining: 0.250 ug/mL, Neutralization: Assay-Dependent
Aliases :
aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA