This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-2 Monoclonal Antibody (S4B6), Functional Grade, eBioscience
catalog :
16-7020-85
quantity :
500 ug
price :
US 436.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
S4B6

The same clone is also sold as:
reactivity :
mouse
citations: 9
Reference
Sheikh A, Lu J, Melese E, Seo J, Abraham N. IL-7 induces type 2 cytokine response in lung ILC2s and regulates GATA3 and CD25 expression. J Leukoc Biol. 2022;112:1105-1113 pubmed publisher
Han S, Chung D, St Paul M, Liu Z, Garcia Batres C, Elford A, et al. Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cells. Oncoimmunology. 2020;9:1737368 pubmed publisher
Castro W, Chelbi S, Niogret C, Ramón Barros C, Welten S, Osterheld K, et al. The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity. Nat Immunol. 2018;19:809-820 pubmed publisher
Chien M, Lin M, Huang S, Fu S, Hsu C, Yen B, et al. Glucosamine Modulates T Cell Differentiation through Down-regulating N-Linked Glycosylation of CD25. J Biol Chem. 2015;290:29329-44 pubmed publisher
Rojas G, Cabrera Infante Y, Pupo A, Carmenate T. Fine epitope specificity of antibodies against interleukin-2 explains their paradoxical immunomodulatory effects. MAbs. 2014;6:273-85 pubmed publisher
Pierson W, Cauwe B, Policheni A, Schlenner S, Franckaert D, Berges J, et al. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3? regulatory T cells. Nat Immunol. 2013;14:959-65 pubmed publisher
Boyman O, Sprent J. The role of interleukin-2 during homeostasis and activation of the immune system. Nat Rev Immunol. 2012;12:180-90 pubmed publisher
Sander B, Höidén I, Andersson U, Moller E, Abrams J. Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. Cytokine detection by immunoassay and intracellular immunostaining. J Immunol Methods. 1993;166:201-14 pubmed
Abrams J, Roncarolo M, Yssel H, Andersson U, Gleich G, Silver J. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol Rev. 1992;127:5-24 pubmed
product information
Product Type :
Antibody
Product Name :
IL-2 Monoclonal Antibody (S4B6), Functional Grade, eBioscience
Catalog # :
16-7020-85
Quantity :
500 ug
Price :
US 436.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Functional Assay: Assay-Dependent
Species :
Mouse
Clone :
S4B6
Isotype :
IgG2a
Storage :
4 C
Description :
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
Format :
Liquid
Applications w/Dilutions :
Functional Assay: Assay-Dependent
Aliases :
aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA