IL-1 alpha Monoclonal Antibody (ALF-161), Functional Grade, eBioscience | Invitrogen 16-7011-85 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-1 alpha Monoclonal Antibody (ALF-161), Functional Grade, eBioscience

catalog :

16-7011-85

quantity :

500 µg

price :

US 362

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

ALF-161

reactivity :

mouse

application :

ELISA, neutralization, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse; loading ...; fig 1c	Bucher H, Mang S, Keck M, Przibilla M, Lamb D, Schiele F, et al. Neutralization of both IL-1α/IL-1β plays a major role in suppressing combined cigarette smoke/virus-induced pulmonary inflammation in mice. Pulm Pharmacol Ther. 2017;44:96-105 pubmed publisher
ELISA; mouse; loading ...; fig 5c	Shutinoski B, Alturki N, Rijal D, Bertin J, Gough P, Schlossmacher M, et al. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ. 2016;23:1628-37 pubmed publisher
	Düsedau H, Kleveman J, Figueiredo C, Biswas A, Steffen J, Kliche S, et al. p75NTR regulates brain mononuclear cell function and neuronal structure in Toxoplasma infection-induced neuroinflammation. Glia. 2019;67:193-211 pubmed publisher
	Kratochvill F, Gratz N, Qualls J, Van De Velde L, Chi H, Kovarik P, et al. Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner. Cancer Res. 2015;75:3054-64 pubmed publisher
	Ehlers M, Thiel A, Papewalis C, Domröse A, Stenzel W, Bernecker C, et al. Enhanced iodine supplementation alters the immune process in a transgenic mouse model for autoimmune thyroiditis. Thyroid. 2014;24:888-96 pubmed publisher
	Casson C, Copenhaver A, Zwack E, Nguyen H, Strowig T, Javdan B, et al. Caspase-11 activation in response to bacterial secretion systems that access the host cytosol. PLoS Pathog. 2013;9:e1003400 pubmed publisher
	Castillo E, Dekonenko A, Arko Mensah J, Mandell M, Dupont N, Jiang S, et al. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A. 2012;109:E3168-76 pubmed publisher
	Gross O, Yazdi A, Thomas C, Masin M, Heinz L, Guarda G, et al. Inflammasome activators induce interleukin-1? secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity. 2012;36:388-400 pubmed publisher
	Gross O. Measuring the inflammasome. Methods Mol Biol. 2012;844:199-222 pubmed publisher
	Mayer Barber K, Andrade B, Barber D, Hieny S, Feng C, Caspar P, et al. Innate and adaptive interferons suppress IL-1Î± and IL-1Î² production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection. Immunity. 2011;35:1023-34 pubmed publisher
	Sprague L, Muccioli M, Pate M, Meles E, McGinty J, Nandigam H, et al. The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells. BMC Immunol. 2011;12:35 pubmed publisher
	Bao Y, Han Y, Chen Z, Xu S, Cao X. IFN-?-producing PDCA-1+ Siglec-H- B cells mediate innate immune defense by activating NK cells. Eur J Immunol. 2011;41:657-68 pubmed publisher
	Gonzalez Navajas J, Law J, Nguyen K, Bhargava M, Corr M, Varki N, et al. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J Exp Med. 2010;207:2799-807 pubmed publisher
	Yazdi A, Guarda G, Riteau N, Drexler S, Tardivel A, Couillin I, et al. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1? and IL-1?. Proc Natl Acad Sci U S A. 2010;107:19449-54 pubmed publisher
	Carmi Y, Voronov E, Dotan S, Lahat N, Rahat M, Fogel M, et al. The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis. J Immunol. 2009;183:4705-14 pubmed publisher
	Peduto L, Dulauroy S, Lochner M, Späth G, Morales M, Cumano A, et al. Inflammation recapitulates the ontogeny of lymphoid stromal cells. J Immunol. 2009;182:5789-99 pubmed publisher
	Xiao X, Kroemer A, Gao W, Ishii N, Demirci G, Li X. OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo. J Immunol. 2008;181:3193-201 pubmed
	Peden D, Petitjean C, Herd M, Durakoglugil M, Rosahl T, Wafford K, et al. Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones. J Physiol. 2008;586:965-87 pubmed

product information

Product Type :

Antibody

Product Name :

IL-1 alpha Monoclonal Antibody (ALF-161), Functional Grade, eBioscience

Catalog # :

16-7011-85

Quantity :

500 µg

Price :

US 362

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Functional Assay: Assay-Dependent, Immunostaining: 0.03 µg/mL, Neutralization: Assay-Dependent

Species :

Mouse

Clone :

ALF-161

Isotype :

IgG

Storage :

4° C

Description :

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Format :

Liquid

Applications w/Dilutions :

Functional Assay: Assay-Dependent, Immunostaining: 0.03 µg/mL, Neutralization: Assay-Dependent

Aliases :

CTLA8; hematopoietin-1; IL 1 a; IL 1a; IL1; IL-1 alpha; IL17; IL1A; Il-1a; IL-1alpha; IL1-ALPHA; IL1F1; IL1a; ILN; Interleukin; interleukin 1 alpha; interleukin 1, alpha; interleukin 17; interleukin 1a; interleukin 1-alpha; interleukin 1-alpha (AA 1 - 152); Interleukin1 alpha; interleukin-1 alpha; interleukin-1 alpha precursor; Interleukin-17A; preinterleukin 1 alpha; pre-interleukin-1 alpha; pro-interleukin-1-alpha; RP23-160G19.8

more info or order :

Invitrogen product webpage