MAdCAM1 Monoclonal Antibody (MECA-367), Functional Grade, eBioscience | Invitrogen 16-5997-85 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MAdCAM1 Monoclonal Antibody (MECA-367), Functional Grade, eBioscience

catalog :

16-5997-85

quantity :

500 µg

price :

US 378.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MECA-367

reactivity :

mouse

application :

immunohistochemistry, neutralization, flow cytometry

more info or order :

Invitrogen product webpage

citations: 24

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; fig 1	Satpathy A, Briseño C, Lee J, Ng D, Manieri N, Kc W, et al. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol. 2013;14:937-48 pubmed publisher
	Jiang L, Yilmaz M, Uehara M, Cavazzoni C, Kasinath V, Zhao J, et al. Characterization of Leptin Receptor+ Stromal Cells in Lymph Node. Front Immunol. 2021;12:730438 pubmed publisher
	Zhang Y, Tech L, George L, Acs A, Durrett R, Hess H, et al. Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells. J Exp Med. 2018;215:1227-1243 pubmed publisher
	KÃ¶chl R, Thelen F, Vanes L, BrazÃ£o T, Fountain K, Xie J, et al. WNK1 kinase balances T cell adhesion versus migration in vivo. Nat Immunol. 2016;17:1075-83 pubmed publisher
	Smigiel K, Richards E, Srivastava S, Thomas K, Dudda J, Klonowski K, et al. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J Exp Med. 2014;211:121-36 pubmed publisher
	Mok Y, Schwierzeck V, Thomas D, Vigorito E, Rayner T, Jarvis L, et al. MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production. J Immunol. 2013;191:3037-3048 pubmed publisher
	Tlaxca J, Rychak J, Ernst P, Konkalmatt P, Shevchenko T, Pizarro T, et al. Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease. J Control Release. 2013;165:216-25 pubmed publisher
	Hindley J, Jones E, Smart K, Bridgeman H, Lauder S, Ondondo B, et al. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion. Cancer Res. 2012;72:5473-82 pubmed publisher
	O CONNOR T, Frei N, Sponarova J, Schwarz P, Heikenwalder M, Aguzzi A. Lymphotoxin, but not TNF, is required for prion invasion of lymph nodes. PLoS Pathog. 2012;8:e1002867 pubmed publisher
	Guerra F, Gommerman J, Corfe S, Paige C, Rottapel R. Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response. PLoS ONE. 2012;7:e35533 pubmed publisher
	Malhotra D, Fletcher A, Astarita J, Lukacs Kornek V, Tayalia P, Gonzalez S, et al. Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol. 2012;13:499-510 pubmed publisher
	Bénézech C, White A, Mader E, Serre K, Parnell S, Pfeffer K, et al. Ontogeny of stromal organizer cells during lymph node development. J Immunol. 2010;184:4521-30 pubmed publisher
	Glanville S, Bekiaris V, Jenkinson E, Lane P, Anderson G, Withers D. Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization. Eur J Immunol. 2009;39:280-9 pubmed publisher
	Withers D, Kim M, Bekiaris V, Rossi S, Jenkinson W, Gaspal F, et al. The role of lymphoid tissue inducer cells in splenic white pulp development. Eur J Immunol. 2007;37:3240-5 pubmed
	Miyake Y, Asano K, Kaise H, Uemura M, Nakayama M, Tanaka M. Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest. 2007;117:2268-78 pubmed
	Chen G, Dimitriou I, La Rose J, Ilangumaran S, Yeh W, Doody G, et al. The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response. Mol Cell Biol. 2007;27:3109-22 pubmed
	Umemoto E, Tanaka T, Kanda H, Jin S, Tohya K, Otani K, et al. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. J Exp Med. 2006;203:1603-14 pubmed
	Coisne C, Dehouck L, Faveeuw C, Delplace Y, Miller F, Landry C, et al. Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium. Lab Invest. 2005;85:734-46 pubmed
	Wen L, Shinton S, Hardy R, Hayakawa K. Association of B-1 B cells with follicular dendritic cells in spleen. J Immunol. 2005;174:6918-26 pubmed
	Fernekorn U, Butcher E, Behrends J, Hartz S, Kruse A. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Eur J Immunol. 2004;34:3423-33 pubmed
	Leung E, Kanwar R, Kanwar J, Krissansen G. Mucosal vascular addressin cell adhesion molecule-1 is expressed outside the endothelial lineage on fibroblasts and melanoma cells. Immunol Cell Biol. 2003;81:320-7 pubmed
	Savinov A, Wong F, Stonebraker A, Chervonsky A. Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells. J Exp Med. 2003;197:643-56 pubmed
	Streeter P, Berg E, Rouse B, Bargatze R, Butcher E. A tissue-specific endothelial cell molecule involved in lymphocyte homing. Nature. 1988;331:41-6 pubmed
	Streeter P, Rouse B, Butcher E. Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes. J Cell Biol. 1988;107:1853-62 pubmed

product information

Product Type :

Antibody

Product Name :

MAdCAM1 Monoclonal Antibody (MECA-367), Functional Grade, eBioscience

Catalog # :

16-5997-85

Quantity :

500 µg

Price :

US 378.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Mouse

Clone :

MECA-367

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

AV211525; hMAdCAM-1; MACAM1; MADCAM1; MAdCAM-1; mMAdCAM-1; mucosal addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule-1; mucosal vascular addressin cell adhesion molecule 1; rMAdCAM-1

more info or order :

Invitrogen product webpage