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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
VEGF Receptor 3 Monoclonal Antibody (AFL4), Functional Grade, eBioscience
catalog :
16-5988-85
quantity :
500 µg
price :
US 442.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
AFL4
reactivity :
mouse
application :
immunohistochemistry, flow cytometry
more info or order :
Invitrogen product webpage
citations: 29
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; fig 4
Kim H, Nguyen V, Petrova T, Cruz M, Alitalo K, Dumont D. Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature. BMC Dev Biol. 2010;10:72 pubmed publisher
Cioffi S, Flore G, Martucciello S, Bilio M, Turturo M, Illingworth E. VEGFR3 modulates brain microvessel branching in a mouse model of 22q11.2 deletion syndrome. Life Sci Alliance. 2022;5: pubmed publisher
Mece O, Houbaert D, Sassano M, Durré T, Maes H, Schaaf M, et al. Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis. Nat Commun. 2022;13:2760 pubmed publisher
Harris A, Esparza S, Azimi M, Cornelison R, Azar F, Llaneza D, et al. Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy. Front Oncol. 2022;12:801764 pubmed publisher
Asosingh K, Weiss K, Queisser K, Wanner N, Yin M, Aronica M, et al. Endothelial cells in the innate response to allergens and initiation of atopic asthma. J Clin Invest. 2018;128:3116-3128 pubmed publisher
Majumder S, Zhu G, Xu X, Senchanthisai S, Jiang D, Liu H, et al. G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling. Cell Rep. 2016;17:2532-2541 pubmed publisher
Tagaram H, Desai D, Li G, Liu D, Rountree C, Gowda K, et al. A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer. Pharmaceuticals (Basel). 2016;9: pubmed publisher
Sato T, Paquet Fifield S, Harris N, Roufail S, Turner D, Yuan Y, et al. VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury. J Pathol. 2016;239:152-61 pubmed publisher
Loder S, Agarwal S, Sorkin M, Breuler C, Li J, Peterson J, et al. Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification. Ann Surg. 2016;264:1174-1180 pubmed
Iwami D, Brinkman C, Bromberg J. Vascular endothelial growth factor c/vascular endothelial growth factor receptor 3 signaling regulates chemokine gradients and lymphocyte migration from tissues to lymphatics. Transplantation. 2015;99:668-77 pubmed publisher
Thiele W, Rothley M, Teller N, Jung N, Bulat B, Plaumann D, et al. Delphinidin is a novel inhibitor of lymphangiogenesis but promotes mammary tumor growth and metastasis formation in syngeneic experimental rats. Carcinogenesis. 2013;34:2804-13 pubmed publisher
Izumi N, Helker C, Ehling M, Behrens A, Herzog W, Adams R. Fbxw7 controls angiogenesis by regulating endothelial Notch activity. PLoS ONE. 2012;7:e41116 pubmed publisher
Jayaraman P, Parikh F, López Rivera E, Hailemichael Y, Clark A, Ma G, et al. Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol. 2012;188:5365-76 pubmed publisher
Cesca F, Yabe A, Spencer Dene B, Scholz Starke J, Medrihan L, Maden C, et al. Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ. 2012;19:194-208 pubmed publisher
Tvorogov D, Anisimov A, Zheng W, Leppänen V, Tammela T, Laurinavicius S, et al. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell. 2010;18:630-40 pubmed publisher
Zhang L, Zhou F, Han W, Shen B, Luo J, Shibuya M, et al. VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res. 2010;20:1319-31 pubmed publisher
Garmy Susini B, Avraamides C, Schmid M, Foubert P, Ellies L, Barnes L, et al. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010;70:3042-51 pubmed publisher
Teller N, Thiele W, Boettler U, Sleeman J, Marko D. Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family. Mol Nutr Food Res. 2009;53:1075-83 pubmed publisher
Taniguchi K, Ishizaki T, Ayada T, Sugiyama Y, Wakabayashi Y, Sekiya T, et al. Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth. Cancer Sci. 2009;100:1648-54 pubmed publisher
Teller N, Thiele W, Marczylo T, Gescher A, Boettler U, Sleeman J, et al. Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes. J Agric Food Chem. 2009;57:3094-101 pubmed publisher
Vondenhoff M, van de Pavert S, Dillard M, Greuter M, Goverse G, Oliver G, et al. Lymph sacs are not required for the initiation of lymph node formation. Development. 2009;136:29-34 pubmed publisher
Yamaguchi T, Ichise T, Iwata O, Hori A, Adachi T, Nakamura M, et al. Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse. FEBS J. 2008;275:1988-98 pubmed publisher
Copland I, Sharma K, Lejeune L, Eliopoulos N, Stewart D, Liu P, et al. CD34 expression on murine marrow-derived mesenchymal stromal cells: impact on neovascularization. Exp Hematol. 2008;36:93-103 pubmed
Garmy Susini B, Makale M, Fuster M, Varner J. Methods to study lymphatic vessel integrins. Methods Enzymol. 2007;426:415-38 pubmed
Taniguchi K, Kohno R, Ayada T, Kato R, Ichiyama K, Morisada T, et al. Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol Cell Biol. 2007;27:4541-50 pubmed
Galvagni F, Anselmi F, Salameh A, Orlandini M, Rocchigiani M, Oliviero S. Vascular endothelial growth factor receptor-3 activity is modulated by its association with caveolin-1 on endothelial membrane. Biochemistry. 2007;46:3998-4005 pubmed
Colucci S, Taraboletti G, Primo L, Viale A, Roca C, Valdembri D, et al. Gorham-Stout syndrome: a monocyte-mediated cytokine propelled disease. J Bone Miner Res. 2006;21:207-18 pubmed
Saaristo A, Partanen T, Arola J, Jussila L, Hytonen M, Makitie A, et al. Vascular endothelial growth factor-C and its receptor VEGFR-3 in the nasal mucosa and in nasopharyngeal tumors. Am J Pathol. 2000;157:7-14 pubmed
Paavonen K, Puolakkainen P, Jussila L, Jahkola T, Alitalo K. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol. 2000;156:1499-504 pubmed
product information
Product Type :
Antibody
Product Name :
VEGF Receptor 3 Monoclonal Antibody (AFL4), Functional Grade, eBioscience
Catalog # :
16-5988-85
Quantity :
500 µg
Price :
US 442.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Control: Assay-Dependent, Flow Cytometry: Assay-Dependent, Functional Assay: Assay-Dependent
Species :
Mouse
Clone :
AFL4
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
Format :
Liquid
Applications w/Dilutions :
Control: Assay-Dependent, Flow Cytometry: Assay-Dependent, Functional Assay: Assay-Dependent
Aliases :
AI323512; Chy; chylous ascites; Flt4; FLT-4; FLT41; fms related tyrosine kinase 4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; PCL; receptor protein tyrosine kinase; soluble VEGFR 3; sVEGFR 3; tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF R3; VEGFR3; VEGFR-3
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA