VEGF Receptor 3 Monoclonal Antibody (AFL4), Functional Grade, eBioscience | Invitrogen 16-5988-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

VEGF Receptor 3 Monoclonal Antibody (AFL4), Functional Grade, eBioscience

catalog :

16-5988-025

quantity :

25 mg

price :

US 8320

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

AFL4

reactivity :

mouse

application :

flow cytometry

citations: 13

Reference
Mece O, Houbaert D, Sassano M, Durré T, Maes H, Schaaf M, et al. Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis. Nat Commun. 2022;13:2760 pubmed publisher
Asosingh K, Weiss K, Queisser K, Wanner N, Yin M, Aronica M, et al. Endothelial cells in the innate response to allergens and initiation of atopic asthma. J Clin Invest. 2018;128:3116-3128 pubmed publisher
Majumder S, Zhu G, Xu X, Senchanthisai S, Jiang D, Liu H, et al. G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling. Cell Rep. 2016;17:2532-2541 pubmed publisher
Tagaram H, Desai D, Li G, Liu D, Rountree C, Gowda K, et al. A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer. Pharmaceuticals (Basel). 2016;9: pubmed publisher
Sato T, Paquet Fifield S, Harris N, Roufail S, Turner D, Yuan Y, et al. VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury. J Pathol. 2016;239:152-61 pubmed publisher
Loder S, Agarwal S, Sorkin M, Breuler C, Li J, Peterson J, et al. Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification. Ann Surg. 2016;264:1174-1180 pubmed
Iwami D, Brinkman C, Bromberg J. Vascular endothelial growth factor c/vascular endothelial growth factor receptor 3 signaling regulates chemokine gradients and lymphocyte migration from tissues to lymphatics. Transplantation. 2015;99:668-77 pubmed publisher
Izumi N, Helker C, Ehling M, Behrens A, Herzog W, Adams R. Fbxw7 controls angiogenesis by regulating endothelial Notch activity. PLoS ONE. 2012;7:e41116 pubmed publisher
Cesca F, Yabe A, Spencer Dene B, Scholz Starke J, Medrihan L, Maden C, et al. Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ. 2012;19:194-208 pubmed publisher
Kim H, Nguyen V, Petrova T, Cruz M, Alitalo K, Dumont D. Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature. BMC Dev Biol. 2010;10:72 pubmed publisher
Taniguchi K, Kohno R, Ayada T, Kato R, Ichiyama K, Morisada T, et al. Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol Cell Biol. 2007;27:4541-50 pubmed
Saaristo A, Partanen T, Arola J, Jussila L, Hytonen M, Makitie A, et al. Vascular endothelial growth factor-C and its receptor VEGFR-3 in the nasal mucosa and in nasopharyngeal tumors. Am J Pathol. 2000;157:7-14 pubmed
Paavonen K, Puolakkainen P, Jussila L, Jahkola T, Alitalo K. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol. 2000;156:1499-504 pubmed

product information

Product Type :

Antibody

Product Name :

VEGF Receptor 3 Monoclonal Antibody (AFL4), Functional Grade, eBioscience

Catalog # :

16-5988-025

Quantity :

25 mg

Price :

US 8320

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Control: Assay-Dependent, Flow Cytometry: Assay-Dependent, Functional Assay: Assay-Dependent

Species :

Mouse

Clone :

AFL4

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.

Format :

Liquid

Applications w/Dilutions :

Control: Assay-Dependent, Flow Cytometry: Assay-Dependent, Functional Assay: Assay-Dependent

Aliases :

AI323512; Chy; chylous ascites; Flt4; FLT-4; FLT41; fms related tyrosine kinase 4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; PCL; receptor protein tyrosine kinase; soluble VEGFR 3; sVEGFR 3; tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF R3; VEGFR3; VEGFR-3