This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD202b (TIE2) Monoclonal Antibody (TEK4), Functional Grade, eBioscience
catalog :
16-5987-82
quantity :
100 ug
price :
US 293.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
TEK4

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 39
Reference
Cao J, Jin L, Yan Z, Wang X, Li Y, Wang Z, et al. Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models. Nat Commun. 2023;14:8461 pubmed publisher
Kim J, Yang Y, Park K, Ge X, Xu R, Li N, et al. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nat Commun. 2020;11:2289 pubmed publisher
HWANG C, Marini S, Huber A, Stepien D, Sorkin M, Loder S, et al. Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Res. 2019;7:36 pubmed publisher
Cervantes Villagrana R, Color Aparicio V, Reyes Cruz G, Vazquez Prado J. Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs. J Cell Commun Signal. 2019;13:179-191 pubmed publisher
Gilmour J, Assi S, Noailles L, Lichtinger M, Obier N, Bonifer C. The Co-operation of RUNX1 with LDB1, CDK9 and BRD4 Drives Transcription Factor Complex Relocation During Haematopoietic Specification. Sci Rep. 2018;8:10410 pubmed publisher
Gulati G, Murphy M, Marecic O, Lopez M, Brewer R, Koepke L, et al. Isolation and functional assessment of mouse skeletal stem cell lineage. Nat Protoc. 2018;13:1294-1309 pubmed publisher
Harney A, Karagiannis G, Pignatelli J, Smith B, Kadioglu E, Wise S, et al. The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors. Mol Cancer Ther. 2017;16:2486-2501 pubmed publisher
Stefanska M, Batta K, Patel R, Florkowska M, Kouskoff V, Lacaud G. Primitive erythrocytes are generated from hemogenic endothelial cells. Sci Rep. 2017;7:6401 pubmed publisher
Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, et al. Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat Commun. 2017;8:16106 pubmed publisher
Karagiannis G, Pastoriza J, Wang Y, Harney A, Entenberg D, Pignatelli J, et al. Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism. Sci Transl Med. 2017;9: pubmed publisher
Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro Oonuma T, Hwang Y, et al. Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. JCI Insight. 2017;2:e90905 pubmed publisher
Agarwal S, Loder S, Sorkin M, Li S, Shrestha S, Zhao B, et al. Analysis of Bone-Cartilage-Stromal Progenitor Populations in Trauma Induced and Genetic Models of Heterotopic Ossification. Stem Cells. 2016;34:1692-701 pubmed publisher
Goode D, Obier N, Vijayabaskar M, Lie A Ling M, Lilly A, Hannah R, et al. Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation. Dev Cell. 2016;36:572-87 pubmed publisher
Loder S, Agarwal S, Sorkin M, Breuler C, Li J, Peterson J, et al. Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification. Ann Surg. 2016;264:1174-1180 pubmed
Siavashi V, Nassiri S, Rahbarghazi R, Vafaei R, Sariri R. ECM-Dependence of Endothelial Progenitor Cell Features. J Cell Biochem. 2016;117:1934-46 pubmed publisher
Shi X, Zirbes K, Rasmussen T, Ferdous A, Garry M, Koyano Nakagawa N, et al. The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression. J Biol Chem. 2015;290:9614-25 pubmed publisher
Gilmour J, Assi S, Jaegle U, Kulu D, van de Werken H, Clarke D, et al. A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification. Development. 2014;141:2391-401 pubmed publisher
Shi X, Richard J, Zirbes K, Gong W, Lin G, Kyba M, et al. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages. Dev Biol. 2014;389:208-18 pubmed publisher
Luo B, Tseng C, Adams G, Lee A. Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells. Stem Cells Dev. 2013;22:3062-73 pubmed publisher
Joo H, Choi D, Lim J, Park J, Lee S, Song S, et al. ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell-derived Flk1(+) mesodermal precursor cells. Blood. 2012;120:2733-44 pubmed
Gasparetto M, Sekulovic S, Zakaryan A, Imren S, Kent D, Humphries R, et al. Varying levels of aldehyde dehydrogenase activity in adult murine marrow hematopoietic stem cells are associated with engraftment and cell cycle status. Exp Hematol. 2012;40:857-66.e5 pubmed publisher
Lancrin C, Mazan M, Stefanska M, Patel R, Lichtinger M, Costa G, et al. GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment. Blood. 2012;120:314-22 pubmed publisher
Sudo T, Yokota T, Oritani K, Satoh Y, Sugiyama T, Ishida T, et al. The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal. J Immunol. 2012;189:200-10 pubmed publisher
Koyano Nakagawa N, Kweon J, Iacovino M, Shi X, Rasmussen T, Borges L, et al. Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells. 2012;30:1611-23 pubmed publisher
Langenkamp E, Vom Hagen F, Zwiers P, Moorlag H, Schouten J, Hammes H, et al. Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged. ISRN Oncol. 2011;2011:409308 pubmed publisher
Rasmussen T, Kweon J, Diekmann M, Belema Bedada F, Song Q, Bowlin K, et al. ER71 directs mesodermal fate decisions during embryogenesis. Development. 2011;138:4801-12 pubmed publisher
Gill J, Langer E, Lindsley R, Cai M, Murphy T, Murphy K. Snail promotes the cell-autonomous generation of Flk1(+) endothelial cells through the repression of the microRNA-200 family. Stem Cells Dev. 2012;21:167-76 pubmed publisher
Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, et al. Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. J Exp Med. 2011;208:949-60 pubmed publisher
Tabruyn S, Colton K, Morisada T, Fuxe J, Wiegand S, Thurston G, et al. Angiopoietin-2-driven vascular remodeling in airway inflammation. Am J Pathol. 2010;177:3233-43 pubmed publisher
Yokomizo T, Dzierzak E. Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos. Development. 2010;137:3651-61 pubmed publisher
Pearson S, Lancrin C, Lacaud G, Kouskoff V. The sequential expression of CD40 and Icam2 defines progressive steps in the formation of blood precursors from the mesoderm germ layer. Stem Cells. 2010;28:1089-98 pubmed publisher
Lancrin C, Sroczynska P, Stephenson C, Allen T, Kouskoff V, Lacaud G. The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature. 2009;457:892-5 pubmed publisher
Li B, Vincent A, Cates J, Brantley Sieders D, Polk D, Young P. Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res. 2009;69:338-48 pubmed publisher
Lu K, Lamagna C, Bergers G. Chapter 3. Bone marrow-derived vascular progenitors and proangiogenic monocytes in tumors. Methods Enzymol. 2008;445:53-82 pubmed publisher
Copland I, Sharma K, Lejeune L, Eliopoulos N, Stewart D, Liu P, et al. CD34 expression on murine marrow-derived mesenchymal stromal cells: impact on neovascularization. Exp Hematol. 2008;36:93-103 pubmed
Tang Y, Borgstrom P, Maynard J, Koziol J, Hu Z, Garen A, et al. Mapping of angiogenic markers for targeting of vectors to tumor vascular endothelial cells. Cancer Gene Ther. 2007;14:346-53 pubmed
Ema M, Yokomizo T, Wakamatsu A, Terunuma T, Yamamoto M, Takahashi S. Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo. Blood. 2006;108:4018-24 pubmed
Yokota T, Huang J, Tavian M, Nagai Y, Hirose J, Zuniga Pflucker J, et al. Tracing the first waves of lymphopoiesis in mice. Development. 2006;133:2041-51 pubmed
Lelievre E, Bourbon P, Duan L, Nussbaum R, Fong G. Deficiency in the p110alpha subunit of PI3K results in diminished Tie2 expression and Tie2(-/-)-like vascular defects in mice. Blood. 2005;105:3935-8 pubmed
product information
Product Type :
Antibody
Product Name :
CD202b (TIE2) Monoclonal Antibody (TEK4), Functional Grade, eBioscience
Catalog # :
16-5987-82
Quantity :
100 ug
Price :
US 293.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Control: Assay-Dependent, Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Species :
Mouse
Clone :
TEK4
Isotype :
IgG1, kappa
Storage :
4 C
Description :
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
Format :
Liquid
Applications w/Dilutions :
Control: Assay-Dependent, Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Aliases :
AA517024; Angiopoietin-1 receptor; CD202B; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; endothelial-specific receptor tyrosine kinase; endothelium-specific receptor tyrosine kinase 2; endothelium-specific receptor tyrosine kinase Tie-2; hTIE2; Hyk; mTIE2; p140 TEK; protein-tyrosine kinase Tie2; STK1; Tek; TEK receptor tyrosine kinase; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; Tie2; tie-2; tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2; tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor Tie-2; VMCM; VMCM1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA