CD276 (B7-H3) Monoclonal Antibody (M3.2D7), Functional Grade, eBioscience | Invitrogen 16-5973-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD276 (B7-H3) Monoclonal Antibody (M3.2D7), Functional Grade, eBioscience

catalog :

16-5973-81

quantity :

50 µg

price :

US 194

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

M3.2D7

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse	Sheng H, Wang Y, Jin Y, Zhang Q, Zhang Y, Wang L, et al. A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res. 2008;18:846-57 pubmed publisher
flow cytometry; mouse; fig 1	Nakae S, Iwakura Y, Suto H, Galli S. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol. 2007;81:1258-68 pubmed
	Hoffmann M, Molina Mendiola C, Nelson A, Parks C, Reyes E, Hansen M, et al. Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo. Sci Adv. 2015;1:e1500415 pubmed publisher
	Zhang G, Huang H, Zhu Y, Yu G, Gao X, Xu Y, et al. A novel subset of B7-H3+CD14+HLA-DR-/low myeloid-derived suppressor cells are associated with progression of human NSCLC. Oncoimmunology. 2015;4:e977164 pubmed
	Chen Y, Yang C, Jin N, Xie Z, Fei L, Jia Z, et al. Sinomenine promotes differentiation but impedes maturation and co-stimulatory molecule expression of human monocyte-derived dendritic cells. Int Immunopharmacol. 2007;7:1102-10 pubmed
	Chen Y, Yang C, Jin N, Xie Z, Tang Y, Fei L, et al. Terminal complement complex C5b-9-treated human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization. Eur J Immunol. 2007;37:167-76 pubmed

product information

Product Type :

Antibody

Product Name :

CD276 (B7-H3) Monoclonal Antibody (M3.2D7), Functional Grade, eBioscience

Catalog # :

16-5973-81

Quantity :

50 µg

Price :

US 194

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Control: Assay-Dependent, Flow Cytometry: 0.5 µg/test, Functional Assay: Assay-Dependent

Species :

Mouse

Clone :

M3.2D7

Isotype :

IgG2a

Storage :

4° C

Description :

CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.

Format :

Liquid

Applications w/Dilutions :

Control: Assay-Dependent, Flow Cytometry: 0.5 µg/test, Functional Assay: Assay-Dependent

Aliases :

4Ig-B7-H3; 6030411F23Rik; AU016588; B7 homolog 3; B7h3; B7-H3; B7RP-2; CD276; CD276 antigen; CD276 molecule; CD276 molecule tv1; costimulatory molecule; PSEC0249; sB7 H3; sB7H3; sCD276; soluble B7 H3; soluble B7H3; soluble CD276; UNQ309/PRO352

more info or order :

Invitrogen product webpage