This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD253 (TRAIL) Monoclonal Antibody (N2B2), Functional Grade, eBioscience
catalog :
16-5951-025
quantity :
25 mg
price :
US 9300.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
N2B2

The same clone is also sold as:
reactivity :
mouse
application :
neutralization, flow cytometry
citations: 13
Reference
Lerner E, Woroniecka K, D Anniballe V, Wilkinson D, Mohan A, Lorrey S, et al. CD8+ T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis. Nat Cancer. 2023;4:1258-1272 pubmed publisher
Sanmarco L, Wheeler M, Gutiérrez Vázquez C, Polonio C, Linnerbauer M, Pinho Ribeiro F, et al. Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021;: pubmed publisher
Wang Y, Dong W, Zhang Y, Caligiuri M, Yu J. Dependence of innate lymphoid cell 1 development on NKp46. PLoS Biol. 2018;16:e2004867 pubmed publisher
Ng S, Souza Fonseca Guimaraes F, Rivera F, Amante F, Kumar R, Gao Y, et al. Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection. Clin Transl Immunology. 2018;7:e1003 pubmed publisher
Estornes Y, Aguileta M, Dubuisson C, De Keyser J, Goossens V, Kersse K, et al. RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions. Cell Death Dis. 2014;5:e1555 pubmed publisher
Deegan S, Saveljeva S, Logue S, Pakos Zebrucka K, Gupta S, Vandenabeele P, et al. Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. Autophagy. 2014;10:1921-36 pubmed publisher
Shin J, Zhang L, Murillo Sauca O, Kim J, Kohrt H, Bui J, et al. Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A. 2013;110:12391-6 pubmed publisher
Gurung P, Rai D, Condotta S, Babcock J, Badovinac V, Griffith T. Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent. J Immunol. 2011;187:2148-54 pubmed publisher
White D, Keppel C, Schneider S, Reese T, Coder J, Payton J, et al. Latent herpesvirus infection arms NK cells. Blood. 2010;115:4377-83 pubmed publisher
Himoudi N, Yan M, Bouma G, Morgenstern D, Wallace R, Seddon B, et al. Migratory and antigen presentation functions of IFN-producing killer dendritic cells. Cancer Res. 2009;69:6598-606 pubmed publisher
Arina A, Murillo O, Dubrot J, Azpilikueta A, Gabari I, Perez Gracia J, et al. Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells. Gene Ther. 2008;15:473-83 pubmed publisher
Mundt B, Wirth T, Zender L, Waltemathe M, Trautwein C, Manns M, et al. Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake. Gut. 2005;54:1590-6 pubmed
Yang Y, Tikhonov I, Ruckwardt T, Djavani M, Zapata J, Pauza C, et al. Monocytes treated with human immunodeficiency virus Tat kill uninfected CD4(+) cells by a tumor necrosis factor-related apoptosis-induced ligand-mediated mechanism. J Virol. 2003;77:6700-8 pubmed
product information
Product Type :
Antibody
Product Name :
CD253 (TRAIL) Monoclonal Antibody (N2B2), Functional Grade, eBioscience
Catalog # :
16-5951-025
Quantity :
25 mg
Price :
US 9300.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Species :
Mouse
Clone :
N2B2
Isotype :
IgG2a, kappa
Storage :
4 C
Description :
TRAIL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TRAIL preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of TRAIL protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Receptors for TRAIL include two death domain containing receptors, death receptor 4 (DR4) and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. TRAIL is a type II membrane protein and expressed in a variety of human tissues. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Aliases :
A330042I21Rik; AI448571; Apo-2 ligand; APO2L; Apo-2L; CD253; CD253 antigen; chemokine tumor necrosis factor ligand superfamily member 10; Ly81; Protein TRAIL; TL2; TN; TNF superfamily member 10; TNF-related apoptosis inducing ligand; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; Tnfsf10; TNLG6A; TRAIL; TRAIL protein; TRAIL/APO2L; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; tumor necrosis factor ligand 6A; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA