DLL4 (delta-like 4) Monoclonal Antibody (HMD4-1), Functional Grade, eBioscience | Invitrogen 16-5948-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DLL4 (delta-like 4) Monoclonal Antibody (HMD4-1), Functional Grade, eBioscience

catalog :

16-5948-82

quantity :

100 µg

price :

US 158

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

HMD4-1

reactivity :

mouse, rat

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 2a	Backer R, Helbig C, Gentek R, Kent A, Laidlaw B, Dominguez C, et al. A central role for Notch in effector CD8(+) T cell differentiation. Nat Immunol. 2014;15:1143-51 pubmed publisher
	Mukherjee S, Rasky A, Lundy P, Kittan N, Kunkel S, Maillard I, et al. STAT5-induced lunatic fringe during Th2 development alters delta-like 4-mediated Th2 cytokine production in respiratory syncytial virus-exacerbated airway allergic disease. J Immunol. 2014;192:996-1003 pubmed publisher
	Joo H, Choi D, Lim J, Park J, Lee S, Song S, et al. ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell-derived Flk1(+) mesodermal precursor cells. Blood. 2012;120:2733-44 pubmed
	Bassil R, Zhu B, Lahoud Y, Riella L, Yagita H, Elyaman W, et al. Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development. J Immunol. 2011;187:2322-8 pubmed publisher
	Sekine C, Moriyama Y, Koyanagi A, Koyama N, Ogata H, Okumura K, et al. Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands. Int Immunol. 2009;21:295-301 pubmed publisher
	Hozumi K, Mailhos C, Negishi N, Hirano K, Yahata T, Ando K, et al. Delta-like 4 is indispensable in thymic environment specific for T cell development. J Exp Med. 2008;205:2507-13 pubmed publisher
	Lobov I, Renard R, Papadopoulos N, Gale N, Thurston G, Yancopoulos G, et al. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A. 2007;104:3219-24 pubmed

product information

Product Type :

Antibody

Product Name :

DLL4 (delta-like 4) Monoclonal Antibody (HMD4-1), Functional Grade, eBioscience

Catalog # :

16-5948-82

Quantity :

100 µg

Price :

US 158

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse, Rat

Applications :

Functional Assay: Assay-Dependent

Species :

Mouse, Rat

Clone :

HMD4-1

Isotype :

IgG

Storage :

4° C

Description :

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.

Format :

Liquid

Applications w/Dilutions :

Functional Assay: Assay-Dependent

Aliases :

AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341

more info or order :

Invitrogen product webpage