DLL4 (delta-like 4) Monoclonal Antibody (HMD4-1), Functional Grade, eBioscience | Invitrogen 16-5948-38 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DLL4 (delta-like 4) Monoclonal Antibody (HMD4-1), Functional Grade, eBioscience

catalog :

16-5948-38

quantity :

5 mg

price :

US 2750

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

HMD4-1

reactivity :

mouse, rat

product information

Product Type :

Antibody

Product Name :

DLL4 (delta-like 4) Monoclonal Antibody (HMD4-1), Functional Grade, eBioscience

Catalog # :

16-5948-38

Quantity :

5 mg

Price :

US 2750

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse, Rat

Applications :

Functional Assay: Assay-Dependent

Species :

Mouse, Rat

Clone :

HMD4-1

Isotype :

IgG

Storage :

4° C

Description :

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.

Format :

Liquid

Applications w/Dilutions :

Functional Assay: Assay-Dependent

Aliases :

AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341