VISTA Monoclonal Antibody (MH5A), Functional Grade, eBioscience | Invitrogen 16-5919-85 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

VISTA Monoclonal Antibody (MH5A), Functional Grade, eBioscience

catalog :

16-5919-85

quantity :

500 ug

price :

US 624.00

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

MH5A

The same clone is also sold as:

BioLegend: 143721, 143717, 143710, 143702, 143705, 143713, 143715, 143723, 143720, 143719, 143707, 143722, 143709, 143718, 143708, 143714, 143712, 143706, 143724

reactivity :

mouse

application :

flow cytometry

citations: 3

Reference
Wang Q, He J, Flies D, Luo L, Chen L. Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability. Sci Rep. 2017;7:6086 pubmed publisher
Flies D, Wang S, Xu H, Chen L. Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models. J Immunol. 2011;187:1537-41 pubmed publisher
Wang L, Rubinstein R, Lines J, Wasiuk A, Ahonen C, Guo Y, et al. VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. J Exp Med. 2011;208:577-92 pubmed publisher

product information

Product Type :

Antibody

Product Name :

VISTA Monoclonal Antibody (MH5A), Functional Grade, eBioscience

Catalog # :

16-5919-85

Quantity :

500 ug

Price :

US 624.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Control: Assay-Dependent, Flow Cytometry: 0.25 ug/test, Functional Assay: Assay-Dependent

Species :

Mouse

Clone :

MH5A

Isotype :

IgG

Storage :

4 C

Description :

VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.

Format :

Liquid

Applications w/Dilutions :

Control: Assay-Dependent, Flow Cytometry: 0.25 ug/test, Functional Assay: Assay-Dependent

Aliases :

4632428N05Rik; B7H5; B7-H5; C10orf54; C1H10orf54; C28H10orf54; C4H10orf54; chromosome 10 open reading frame 54; DD1alpha; Death Domain1alpha; Dies1; differentiation of ESCs 1; GI24; PD-1H; PDCD1 homolog; PD-H1; platelet receptor Gi24; PP2135; RIKEN cDNA 4632428N05 gene; SISP1; sisp-1; Stress-induced secreted protein-1; UNQ730/PRO1412; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation