CD178 (Fas Ligand) Monoclonal Antibody (MFL3), Functional Grade, eBioscience | Invitrogen 16-5911-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD178 (Fas Ligand) Monoclonal Antibody (MFL3), Functional Grade, eBioscience

catalog :

16-5911-82

quantity :

100 µg

price :

US 191

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

MFL3

reactivity :

mouse

application :

neutralization, immunoprecipitation, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 41

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse; loading ...	Marshall N, Vong A, Devarajan P, Brauner M, Kuang Y, Nayar R, et al. NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection. J Immunol. 2017;198:1142-1155 pubmed publisher
immunoprecipitation; mouse; loading ...; fig 6f	Castillo E, Zheng H, Van Cabanlong C, Dong F, Luo Y, Yang Y, et al. Lumican negatively controls the pathogenicity of murine encephalitic TH17 cells. Eur J Immunol. 2016;46:2852-2861 pubmed publisher
flow cytometry; mouse	Tassi I, Claudio E, Wang H, Tang W, Ha H, Saret S, et al. The NF-ÎºB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity. J Immunol. 2014;193:4303-11 pubmed publisher
flow cytometry; mouse; fig 3	Zou Y, Chen T, Han M, Wang H, Yan W, Song G, et al. Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure. J Immunol. 2010;184:466-75 pubmed publisher
flow cytometry; mouse; fig 2	Nakae S, Iwakura Y, Suto H, Galli S. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol. 2007;81:1258-68 pubmed
	Deng R, Hurtz C, Song Q, Yue C, Xiao G, Yu H, et al. Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease. Nat Commun. 2017;8:978 pubmed publisher
	Hu T, Fan X, Ma L, Liu J, Chang Y, Yang P, et al. TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression. Int J Mol Med. 2017;40:1504-1510 pubmed publisher
	Cabral Piccin M, Guillermo L, Vellozo N, Filardy A, Pereira Marques S, Rigoni T, et al. Apoptotic CD8 T-lymphocytes disable macrophage-mediated immunity to Trypanosoma cruzi infection. Cell Death Dis. 2016;7:e2232 pubmed publisher
	Malek Abrahimians E, Vander Elst L, Carlier V, Saint Remy J. Thioreductase-Containing Epitopes Inhibit the Development of Type 1 Diabetes in the NOD Mouse Model. Front Immunol. 2016;7:67 pubmed publisher
	Zhang J, Han C, Dai H, Hou J, Dong Y, Cui X, et al. Hypoxia-Inducible Factor-2Î± Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury. J Am Soc Nephrol. 2016;27:92-106 pubmed publisher
	Uchiyama R, Yonehara S, Tsutsui H. Fas-mediated inflammatory response in Listeria monocytogenes infection. J Immunol. 2013;190:4245-54 pubmed publisher
	Ramon S, Bancos S, Thatcher T, Murant T, Moshkani S, Sahler J, et al. Peroxisome proliferator-activated receptor ? B cell-specific-deficient mice have an impaired antibody response. J Immunol. 2012;189:4740-7 pubmed publisher
	Nakagawa Y, Shimizu M, Norose Y, Takahashi M, Takahashi H. Induction of rapid apoptosis for class I MHC molecule-restricted CD8(+) HIV-1 gp160-specific murine activated CTLs by free antigenic peptide in vivo. Int Immunol. 2013;25:11-24 pubmed publisher
	Cai Z, Yang F, Yu L, Yu Z, Jiang L, Wang Q, et al. Activated T cell exosomes promote tumor invasion via Fas signaling pathway. J Immunol. 2012;188:5954-61 pubmed publisher
	Li Z, Zhang C, Zhou Z, Zhang J, Zhang J, Tian Z. Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor ?? are involved in bacterial clearance during Salmonella enterica serovar Typhimurium infection. Infect Immun. 2012;80:565-74 pubmed publisher
	Brincks E, Gurung P, Langlois R, Hemann E, Legge K, Griffith T. The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL. J Immunol. 2011;187:4581-8 pubmed publisher
	Yeo C, Fearon D. T-bet-mediated differentiation of the activated CD8+ T cell. Eur J Immunol. 2011;41:60-6 pubmed publisher
	Hwang W, Jung K, Jeon Y, Yun S, Kim T, Choi I. Knockdown of the interleukin-6 receptor alpha chain of dendritic cell vaccines enhances the therapeutic potential against IL-6 producing tumors. Vaccine. 2010;29:34-44 pubmed publisher
	Sugiura D, Denda Nagai K, Takeda K, Irimura T. Organ microenvironment plays significant roles through Fas ligand in vaccine-induced CD4(+) T cell dependent suppression of tumor growth at the orthotopic site. Cancer Sci. 2010;101:1965-9 pubmed publisher
	Langlois R, Legge K. Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells. J Immunol. 2010;184:4440-6 pubmed publisher
	White D, Keppel C, Schneider S, Reese T, Coder J, Payton J, et al. Latent herpesvirus infection arms NK cells. Blood. 2010;115:4377-83 pubmed publisher
	Feng X, Ippolito G, Tian L, Wiehagen K, Oh S, Sambandam A, et al. Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development. Blood. 2010;115:510-8 pubmed publisher
	Moriwaki K, Noda K, Furukawa Y, Ohshima K, Uchiyama A, Nakagawa T, et al. Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. Gastroenterology. 2009;137:188-98, 198.e1-2 pubmed publisher
	Mise Omata S, Kuroda E, Sugiura T, Yamashita U, Obata Y, Doi T. The NF-kappaB RelA subunit confers resistance to Leishmania major by inducing nitric oxide synthase 2 and Fas expression but not Th1 differentiation. J Immunol. 2009;182:4910-6 pubmed publisher
	Cheng L, You Q, Yin H, Holt M, Franklin C, Ju C. Effect of polyI:C cotreatment on halothane-induced liver injury in mice. Hepatology. 2009;49:215-26 pubmed publisher
	Frenzel L, Abdullah Z, Kriegeskorte A, Dieterich R, Lange N, Busch D, et al. Role of natural-killer group 2 member D ligands and intercellular adhesion molecule 1 in natural killer cell-mediated lysis of murine embryonic stem cells and embryonic stem cell-derived cardiomyocytes. Stem Cells. 2009;27:307-16 pubmed publisher
	Ruffell B, Johnson P. Hyaluronan induces cell death in activated T cells through CD44. J Immunol. 2008;181:7044-54 pubmed
	Tokita D, Sumpter T, Raimondi G, Zahorchak A, Wang Z, Nakao A, et al. Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells. J Hepatol. 2008;49:1008-18 pubmed publisher
	Brincks E, Katewa A, Kucaba T, Griffith T, Legge K. CD8 T cells utilize TRAIL to control influenza virus infection. J Immunol. 2008;181:4918-25 pubmed
	Huang B, Mao C, Peng S, Hung C, Wu T. RNA interference-mediated in vivo silencing of fas ligand as a strategy for the enhancement of DNA vaccine potency. Hum Gene Ther. 2008;19:763-73 pubmed publisher
	Zhang Y, Xu G, Zhang L, Roberts A, Shi Y. Th17 cells undergo Fas-mediated activation-induced cell death independent of IFN-gamma. J Immunol. 2008;181:190-6 pubmed
	Murakami T, Sato A, Chun N, Hara M, Naito Y, Kobayashi Y, et al. Transcriptional modulation using HDACi depsipeptide promotes immune cell-mediated tumor destruction of murine B16 melanoma. J Invest Dermatol. 2008;128:1506-16 pubmed publisher
	Gong Y, Zhang R, Zhang J, Xu L, Zhang F, Xu W, et al. Alpha-dystroglycan is involved in positive selection of thymocytes by participating in immunological synapse formation. FASEB J. 2008;22:1426-39 pubmed publisher
	McKinstry K, Golech S, Lee W, Huston G, Weng N, Swain S. Rapid default transition of CD4 T cell effectors to functional memory cells. J Exp Med. 2007;204:2199-211 pubmed
	Priatel J, Chen X, Zenewicz L, Shen H, Harder K, Horwitz M, et al. Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion. J Immunol. 2007;179:2143-52 pubmed
	Li M, Wang Y, Guo R, Bai Y, Yu Z. Glucocorticoids impair microglia ability to induce T cell proliferation and Th1 polarization. Immunol Lett. 2007;109:129-37 pubmed
	Zhang J, Gong Y, Shao X, Zhang R, Xu W, Chu Y, et al. Asynchronism of thymocyte development in vivo and in vitro. DNA Cell Biol. 2007;26:19-27 pubmed
	Buhtoiarov I, Sondel P, Eickhoff J, Rakhmilevich A. Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides. Immunology. 2007;120:412-23 pubmed
	Ishiyama K, Ohdan H, Tokita D, Shishida M, Tanaka Y, Irei T, et al. Induction of endotoxin tolerance inhibits alloimmune responses. Transpl Immunol. 2006;16:158-65 pubmed
	Tokita D, Shishida M, Ohdan H, Onoe T, Hara H, Tanaka Y, et al. Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity. J Immunol. 2006;177:3615-24 pubmed
	Onoe T, Ohdan H, Tokita D, Shishida M, Tanaka Y, Hara H, et al. Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice. J Immunol. 2005;175:139-46 pubmed

product information

Product Type :

Antibody

Product Name :

CD178 (Fas Ligand) Monoclonal Antibody (MFL3), Functional Grade, eBioscience

Catalog # :

16-5911-82

Quantity :

100 µg

Price :

US 191

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Mouse

Clone :

MFL3

Isotype :

IgG

Storage :

4° C

Description :

CD178 (Fas ligand, FasL) is a type-II-membrane protein, whose N-terminus is in the cytoplasm and its C-terminal region extends into the extracellular space. Its receptor, FasR, is a cell-surface-type-I-membrane protein and a member of the tumor necrosis factor (TNF) and nerve growth factor (NGF) receptor family. As a member of the TNF-cytokine family CD178 induces apoptosis when interacting with FasR. CD178 may exist as either membrane bound (45 kD) or soluble forms (26 kD). The soluble protein can be released from cells upon cleavage by metalloproteinases. Binding of CD178 to Fas leads to oligomerization of the receptor and triggers apoptotic cell death through the interaction of other proteins. CD178 is predominantly expressed in activated T-lymphocytes and natural killer (NK) cells also it is expressed in the tissues of immune-privilege sites such as testis and eye. CD178 expression is also reported in various tissues as thymus, liver, ovary, lung, heart and kidney. It is assumed that induction of apoptosis through CD178 is predominantly involved in anti-viral immune responses. CD178 is a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis. Various cells express FAS, where CD178 is expressed predominantly on activated T cells. FAS and CD178 are involved in the down-regulation of immune reactions as well as T cell-mediated cytotoxicity. CD178 concentration has also been shown to be associated with atherosclerosis and inflammatory disease, in patients with hypertension. The Fas/ CD178 system has been shown to play a role in a number of human diseases, for example AIDS, hepatitis or cancer.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

ADAM10-processed FasL form; ALPS1B; APL; Apoptosis (APO 1) antigen ligand 1; apoptosis (APO-1) antigen ligand 1; Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand); apoptosis antigen ligand; APT1LG1; APTL; CD178; CD178 antigen; CD95 ligand; CD95 ligand protein;Generalized lymphoproliferative disease (Gld); Cd95l; CD95-L; CD95L protein; fas antigen ligand; Fas ligand; Fas ligand (TNF superfamily, member 6); Fasl; Fas-L; FasL ICD; FasL intracellular domain; Faslg; Fas-LG; generalized lymphoproliferative disease; gld; mutant tumor necrosis factor family member 6; Receptor-binding FasL ectodomain; sFasL; Soluble Fas ligand; soluble form; SPA; SPPL2A-processed FasL form; TNFL; Tnfsf6; TNLG1A; Tumor necrosis factor (ligand) superfamily member 6; Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand); Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand); Tumor necrosis factor ligand; tumor necrosis factor ligand 1A; tumor necrosis factor ligand superfamily member 6; Tumor necrosis factor ligand superfamily member 6 (TNFL6 / TNFSF6); Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form

more info or order :

Invitrogen product webpage