FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), Functional Grade, eBioscience | Invitrogen 16-5899-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), Functional Grade, eBioscience

catalog :

16-5899-82

quantity :

100 µg

price :

US 330

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AER-37 (CRA1)

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 36

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:100; fig 3c	Sanyal R, Pavel A, Glickman J, Chan T, Zheng X, Zhang N, et al. Atopic dermatitis in African American patients is TH2/TH22-skewed with TH1/TH17 attenuation. Ann Allergy Asthma Immunol. 2019;122:99-110.e6 pubmed publisher
flow cytometry; human; fig 1	Shade K, Platzer B, Washburn N, Mani V, Bartsch Y, Conroy M, et al. A single glycan on IgE is indispensable for initiation of anaphylaxis. J Exp Med. 2015;212:457-67 pubmed publisher
immunocytochemistry; human; loading ...; fig 1a	Morshed M, Hlushchuk R, Simon D, Walls A, Obata Ninomiya K, Karasuyama H, et al. NADPH oxidase-independent formation of extracellular DNA traps by basophils. J Immunol. 2014;192:5314-23 pubmed publisher
	Raap U, Gehring M, Kleiner S, Rüdrich U, Eiz Vesper B, Haas H, et al. Human basophils are a source of - and are differentially activated by - IL-31. Clin Exp Allergy. 2017;47:499-508 pubmed publisher
	Henry E, Sy C, Inclan Rico J, Espinosa V, Ghanny S, Dwyer D, et al. Carbonic anhydrase enzymes regulate mast cell-mediated inflammation. J Exp Med. 2016;213:1663-73 pubmed publisher
	Santos A, Du Toit G, Douiri A, Radulovic S, Stephens A, Turcanu V, et al. Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut. J Allergy Clin Immunol. 2015;135:179-86 pubmed publisher
	Greer A, Wu N, Putnam A, Woodruff P, Wolters P, Kinet J, et al. Serum IgE clearance is facilitated by human Fc?RI internalization. J Clin Invest. 2014;124:1187-98 pubmed publisher
	Suurmond J, Stoop J, Rivellese F, Bakker A, Huizinga T, Toes R. Activation of human basophils by combined toll-like receptor- and Fc?RI-triggering can promote Th2 skewing of naive T helper cells. Eur J Immunol. 2014;44:386-96 pubmed publisher
	Okayama Y, Matsuda A, Kashiwakura J, Sasaki Sakamoto T, Nunomura S, Shimokawa T, et al. Highly expressed cytoplasmic Fc?RI? in human mast cells functions as a negative regulator of the FcR?-mediated cell activation signal. Clin Exp Allergy. 2014;44:238-49 pubmed publisher
	Hatada Y, Kashiwakura J, Hayama K, Fujisawa D, Sasaki Sakamoto T, Terui T, et al. Significantly high levels of anti-dsDNA immunoglobulin E in sera and the ability of dsDNA to induce the degranulation of basophils from chronic urticaria patients. Int Arch Allergy Immunol. 2013;161 Suppl 2:154-8 pubmed publisher
	Kashiwakura J, Yanagisawa M, Lee H, Okamura Y, Sasaki Sakamoto T, Saito S, et al. Interleukin-33 synergistically enhances immune complex-induced tumor necrosis factor alpha and interleukin-8 production in cultured human synovium-derived mast cells. Int Arch Allergy Immunol. 2013;161 Suppl 2:32-6 pubmed publisher
	Alcañiz L, Vega A, Chacón P, El Bekay R, Ventura I, Aroca R, et al. Histamine production by human neutrophils. FASEB J. 2013;27:2902-10 pubmed publisher
	Herrmann N, Koch S, Leib N, Bedorf J, Wilms H, Schnautz S, et al. TLR2 down-regulates Fc?RI and its transcription factor PU.1 in human Langerhans cells. Allergy. 2013;68:621-8 pubmed publisher
	Bratke K, Prieschenk C, Garbe K, Kuepper M, Lommatzsch M, Virchow J. Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment. Clin Exp Allergy. 2013;43:312-21 pubmed publisher
	Lee H, Kashiwakura J, Matsuda A, Watanabe Y, Sakamoto Sasaki T, Matsumoto K, et al. Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through Fc? receptor I and Fc? receptor II. Arthritis Rheum. 2013;65:109-19 pubmed publisher
	Davis L, Bhutani S, Barnett S, Khan D. Early gene expression changes with rush immunotherapy. Clin Mol Allergy. 2011;9:12 pubmed publisher
	Lexmond W, der Mee J, Ruiter F, Platzer B, Stary G, Yen E, et al. Development and validation of a standardized ELISA for the detection of soluble Fc-epsilon-RI in human serum. J Immunol Methods. 2011;373:192-9 pubmed publisher
	Schneider E, Machavoine F, Bricard Rignault R, Levasseur M, Petit Bertron A, Gautron S, et al. Downregulation of basophil-derived IL-4 and in vivo T(H)2 IgE responses by serotonin and other organic cation transporter 3 ligands. J Allergy Clin Immunol. 2011;128:864-871.e2 pubmed publisher
	Dehlink E, Platzer B, Baker A, Larosa J, Pardo M, Dwyer P, et al. A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. PLoS ONE. 2011;6:e19098 pubmed publisher
	Bratke K, Klein C, Kuepper M, Lommatzsch M, Virchow J. Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus. Allergy. 2011;66:386-95 pubmed publisher
	Cabezón R, Sintes J, Llinàs L, Benitez Ribas D. Analysis of HLDA9 mAbs on plasmacytoid dendritic cells. Immunol Lett. 2011;134:167-73 pubmed publisher
	Dehlink E, Baker A, Yen E, Nurko S, Fiebiger E. Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. PLoS ONE. 2010;5:e12204 pubmed publisher
	Yen E, Hornick J, Dehlink E, Dokter M, Baker A, Fiebiger E, et al. Comparative analysis of Fc?RI expression patterns in patients with eosinophilic and reflux esophagitis. J Pediatr Gastroenterol Nutr. 2010;51:584-92 pubmed publisher
	Manzouri B, Ohbayashi M, Leonardi A, Fattah D, Larkin D, Ono S. Characterisation of the phenotype and function of monocyte-derived dendritic cells in allergic conjunctiva. Br J Ophthalmol. 2010;94:1662-7 pubmed publisher
	Schroeder J, Bieneman A, Chichester K, Hamilton R, Xiao H, Saini S, et al. Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralization. J Allergy Clin Immunol. 2010;125:896-901.e6 pubmed publisher
	Singleton T, Platzer B, Dehlink E, Fiebiger E. The first transmembrane region of the beta-chain stabilizes the tetrameric Fc epsilon RI complex. Mol Immunol. 2009;46:2333-9 pubmed publisher
	Le T, Tversky J, Chichester K, Bieneman A, Huang S, Wood R, et al. Interferons modulate Fc epsilon RI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells. J Allergy Clin Immunol. 2009;123:217-23 pubmed publisher
	Foroughi S, Foster B, Kim N, Bernardino L, Scott L, Hamilton R, et al. Anti-IgE treatment of eosinophil-associated gastrointestinal disorders. J Allergy Clin Immunol. 2007;120:594-601 pubmed
	Monteseirín J, Vega A, Chacón P, Camacho M, El Bekay R, Asturias J, et al. Neutrophils as a novel source of eosinophil cationic protein in IgE-mediated processes. J Immunol. 2007;179:2634-41 pubmed
	Hasannejad H, Takahashi R, Kimishima M, Hayakawa K, Shiohara T. Selective impairment of Toll-like receptor 2-mediated proinflammatory cytokine production by monocytes from patients with atopic dermatitis. J Allergy Clin Immunol. 2007;120:69-75 pubmed
	Oldhoff J, Knol E, Laaper Ertmann M, Bruijnzeel Koomen C, de Bruin Weller M. Modulation of the atopy patch test: tacrolimus 0.1% compared with triamcinolone acetonide 0.1%. Allergy. 2006;61:622-8 pubmed
	Bachelet I, Munitz A, Moretta A, Moretta L, Levi Schaffer F. The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. J Immunol. 2005;175:7989-95 pubmed
	Suzukawa M, Hirai K, Iikura M, Nagase H, Komiya A, Yoshimura Uchiyama C, et al. IgE- and FcepsilonRI-mediated migration of human basophils. Int Immunol. 2005;17:1249-55 pubmed
	Chacón P, Vega A, Monteseirín J, El Bekay R, Alba G, Pérez Formoso J, et al. Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. Eur J Immunol. 2005;35:2313-24 pubmed
	Munitz A, Bachelet I, Fraenkel S, Katz G, Mandelboim O, Simon H, et al. 2B4 (CD244) is expressed and functional on human eosinophils. J Immunol. 2005;174:110-8 pubmed
	Yamaguchi M, Sayama K, Yano K, Lantz C, Noben Trauth N, Ra C, et al. IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and me. J Immunol. 1999;162:5455-65 pubmed

product information

Product Type :

Antibody

Product Name :

FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), Functional Grade, eBioscience

Catalog # :

16-5899-82

Quantity :

100 µg

Price :

US 330

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent

Species :

Human

Clone :

AER-37 (CRA1)

Isotype :

IgG2b, kappa

Storage :

4° C

Description :

FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent

Aliases :

alpha polypeptide; fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; Iger01; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RATIGER01; RP11-550P17.3

more info or order :

Invitrogen product webpage