FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), Functional Grade, eBioscience | Invitrogen 16-5899-38 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), Functional Grade, eBioscience

catalog :

16-5899-38

quantity :

5 mg

price :

US 2570

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AER-37 (CRA1)

reactivity :

human

application :

immunohistochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:100; fig 3c	Sanyal R, Pavel A, Glickman J, Chan T, Zheng X, Zhang N, et al. Atopic dermatitis in African American patients is TH2/TH22-skewed with TH1/TH17 attenuation. Ann Allergy Asthma Immunol. 2019;122:99-110.e6 pubmed publisher
	Santos A, Du Toit G, Douiri A, Radulovic S, Stephens A, Turcanu V, et al. Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut. J Allergy Clin Immunol. 2015;135:179-86 pubmed publisher
	Morshed M, Hlushchuk R, Simon D, Walls A, Obata Ninomiya K, Karasuyama H, et al. NADPH oxidase-independent formation of extracellular DNA traps by basophils. J Immunol. 2014;192:5314-23 pubmed publisher
	Greer A, Wu N, Putnam A, Woodruff P, Wolters P, Kinet J, et al. Serum IgE clearance is facilitated by human Fc?RI internalization. J Clin Invest. 2014;124:1187-98 pubmed publisher
	Davis L, Bhutani S, Barnett S, Khan D. Early gene expression changes with rush immunotherapy. Clin Mol Allergy. 2011;9:12 pubmed publisher
	Lexmond W, der Mee J, Ruiter F, Platzer B, Stary G, Yen E, et al. Development and validation of a standardized ELISA for the detection of soluble Fc-epsilon-RI in human serum. J Immunol Methods. 2011;373:192-9 pubmed publisher
	Dehlink E, Platzer B, Baker A, Larosa J, Pardo M, Dwyer P, et al. A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. PLoS ONE. 2011;6:e19098 pubmed publisher
	Yen E, Hornick J, Dehlink E, Dokter M, Baker A, Fiebiger E, et al. Comparative analysis of Fc?RI expression patterns in patients with eosinophilic and reflux esophagitis. J Pediatr Gastroenterol Nutr. 2010;51:584-92 pubmed publisher
	Foroughi S, Foster B, Kim N, Bernardino L, Scott L, Hamilton R, et al. Anti-IgE treatment of eosinophil-associated gastrointestinal disorders. J Allergy Clin Immunol. 2007;120:594-601 pubmed

product information

Product Type :

Antibody

Product Name :

FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), Functional Grade, eBioscience

Catalog # :

16-5899-38

Quantity :

5 mg

Price :

US 2570

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent

Species :

Human

Clone :

AER-37 (CRA1)

Isotype :

IgG2b, kappa

Storage :

4° C

Description :

FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent

Aliases :

alpha polypeptide; fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; Iger01; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RATIGER01; RP11-550P17.3

more info or order :

Invitrogen product webpage