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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
NKG2A/C/E Monoclonal Antibody (20d5), Functional Grade, eBioscience
catalog :
16-5896-85
quantity :
500 µg
price :
US 316
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
20d5
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 26
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 2
Guo H, Cranert S, Lu Y, Zhong M, Zhang S, Chen J, et al. Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. J Exp Med. 2016;213:2187-207 pubmed publisher
  • flow cytometry; mouse; fig s2b
Wang S, Xia P, Chen Y, Huang G, Xiong Z, Liu J, et al. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection. Immunity. 2016;45:131-44 pubmed publisher
  • flow cytometry; mouse; 1:100; fig s4
Ludigs K, Jandus C, Utzschneider D, Staehli F, Bessoles S, Dang A, et al. NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nat Commun. 2016;7:10554 pubmed publisher
  • flow cytometry; mouse; fig 5
Wensveen F, Jelenčić V, Valentić S, Šestan M, Wensveen T, Theurich S, et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015;16:376-85 pubmed publisher
Wang X, Piersma S, Nelson C, Dai Y, Christensen T, Lazear E, et al. A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement. elife. 2018;7: pubmed publisher
Ohs I, Van Den Broek M, Nussbaum K, MUNZ C, Arnold S, Quezada S, et al. Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis. Nat Commun. 2016;7:13708 pubmed publisher
Sullivan R, Fogel L, Leong J, Schneider S, Wong R, Romee R, et al. MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013;191:5904-13 pubmed publisher
Trotta R, Chen L, Costinean S, Josyula S, Mundy Bosse B, Ciarlariello D, et al. Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells. Blood. 2013;121:3126-34 pubmed publisher
Strutt T, McKinstry K, Kuang Y, Bradley L, Swain S. Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors. Proc Natl Acad Sci U S A. 2012;109:E2551-60 pubmed
Yang R, Kalogriopoulos N, Rakhmilevich A, Ranheim E, Seo S, Kim K, et al. Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention. J Immunol. 2012;189:2656-64 pubmed publisher
Bao Y, Zheng J, Han C, Jin J, Han H, Liu Y, et al. Tyrosine kinase Btk is required for NK cell activation. J Biol Chem. 2012;287:23769-78 pubmed publisher
Yoshizawa K, Nakajima S, Notake T, Miyagawa S, Hida S, Taki S. IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/- mice. J Immunol. 2011;187:5162-9 pubmed publisher
Pegram H, Haynes N, Smyth M, Kershaw M, Darcy P. Characterizing the anti-tumor function of adoptively transferred NK cells in vivo. Cancer Immunol Immunother. 2010;59:1235-46 pubmed publisher
Lucas M, Vonarbourg C, Aichele P, Diefenbach A. Studying NK cell/dendritic cell interactions. Methods Mol Biol. 2010;612:97-126 pubmed publisher
Aust J, Gays F, Mickiewicz K, Buchanan E, Brooks C. The expression and function of the NKRP1 receptor family in C57BL/6 mice. J Immunol. 2009;183:106-16 pubmed publisher
Jänner N, Hahnke K, Mollenkopf H, Steinhoff U, Kaufmann S, Mittrücker H. Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine. Immunology. 2008;125:38-47 pubmed publisher
Shiraishi K, Ishiwata Y, Nakagawa K, Yokochi S, Taruki C, Akuta T, et al. Enhancement of antitumor radiation efficacy and consistent induction of the abscopal effect in mice by ECI301, an active variant of macrophage inflammatory protein-1alpha. Clin Cancer Res. 2008;14:1159-66 pubmed publisher
Kim N, Saudemont A, Webb L, Camps M, Ruckle T, Hirsch E, et al. The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion. Blood. 2007;110:3202-8 pubmed
Boos M, Yokota Y, Eberl G, Kee B. Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. J Exp Med. 2007;204:1119-30 pubmed
Das G, Das J, Eynott P, Zhang Y, Bothwell A, Van Kaer L, et al. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med. 2006;203:2603-11 pubmed
Rogers S, Rouhi A, Takei F, Mager D. A role for DNA hypomethylation and histone acetylation in maintaining allele-specific expression of mouse NKG2A in developing and mature NK cells. J Immunol. 2006;177:414-21 pubmed
Claassen E, Van der Kant P, Rychnavska Z, van Bleek G, Easton A, van der Most R. Activation and inactivation of antiviral CD8 T cell responses during murine pneumovirus infection. J Immunol. 2005;175:6597-604 pubmed
Uldrich A, Crowe N, Kyparissoudis K, Pellicci D, Zhan Y, Lew A, et al. NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge. J Immunol. 2005;175:3092-3101 pubmed
Gays F, Martin K, Kenefeck R, Aust J, Brooks C. Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells. J Immunol. 2005;175:2938-47 pubmed
Tassi I, Presti R, Kim S, Yokoyama W, Gilfillan S, Colonna M. Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors. J Immunol. 2005;175:749-54 pubmed
Kraft J, Vance R, Pohl J, Martin A, Raulet D, Jensen P. Analysis of Qa-1(b) peptide binding specificity and the capacity of CD94/NKG2A to discriminate between Qa-1-peptide complexes. J Exp Med. 2000;192:613-24 pubmed
product information
Product Type :
Antibody
Product Name :
NKG2A/C/E Monoclonal Antibody (20d5), Functional Grade, eBioscience
Catalog # :
16-5896-85
Quantity :
500 µg
Price :
US 316
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Control: Assay-Dependent, Flow Cytometry: 0.06 µg/test, Functional assay: Assay-Dependent
Species :
Mouse
Clone :
20d5
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
Format :
Liquid
Applications w/Dilutions :
Control: Assay-Dependent, Flow Cytometry: 0.06 µg/test, Functional assay: Assay-Dependent
Aliases :
CD159a; cd159c; cd159e; Cluster of Differentiation 159a; killer cell lectin-like receptor subfamily C, member 1; killer cell lectin-like receptor subfamily C, member 2; killer cell lectin-like receptor subfamily C, member 3; Klrc1; Klrc2; Klrc3; natural killer cell group 2E cell receptor; NKG2; NKG2A; NKG2-A/NKG2-B type II integral membrane protein; NKG2B; NKG2C; Nkg2e
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA