This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
KLRG1 Monoclonal Antibody (2F1), Functional Grade, eBioscience
catalog :
16-5893-050
quantity :
50 mg
price :
US 13750
clonality :
monoclonal
host :
Syrian golden hamster
conjugate :
nonconjugated
clone name :
2F1
reactivity :
mouse
application :
flow cytometry
citations: 49
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s2a
Tizian C, Lahmann A, Hölsken O, Cosovanu C, Kofoed Branzk M, Heinrich F, et al. c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; fig s5a
Wei J, Long L, Zheng W, Dhungana Y, Lim S, Guy C, et al. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019;576:471-476 pubmed publisher
Cannons J, Villarino A, Kapnick S, Preite S, Shih H, Gomez Rodriguez J, et al. PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory. Cell Rep. 2021;37:109804 pubmed publisher
Yun J, Lee C, Liu T, Liu S, Kim E, Xu S, et al. Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice. JCI Insight. 2021;6: pubmed publisher
Tata A, Dodard G, Fug xe8 re C, Leget C, Ors M, Rossi B, et al. Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers. Oncoimmunology. 2021;10:1933808 pubmed publisher
Li Z, Morman R, Hegermiller E, Sun M, Bartom E, Maienschein Cline M, et al. The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude. J Exp Med. 2021;218: pubmed publisher
Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, et al. Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function. Proc Natl Acad Sci U S A. 2020;117:20696-20705 pubmed publisher
Chan I, Knútsdóttir H, Ramakrishnan G, Padmanaban V, Warrier M, Ramirez J, et al. Cancer cells educate natural killer cells to a metastasis-promoting cell state. J Cell Biol. 2020;219: pubmed publisher
Wang S, Qu Y, Xia P, Chen Y, Zhu X, Zhang J, et al. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. Cell Res. 2020;30:610-622 pubmed publisher
Rana A, de Almeida F, Paico Montero H, Gonzales Carazas M, Bortoluci K, Sad S, et al. RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes. Front Immunol. 2020;11:536 pubmed publisher
Chen L, Christian D, Kochanowsky J, Phan A, Clark J, Wang S, et al. The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses. J Exp Med. 2020;217: pubmed publisher
Poholek C, Dulson S, Zajac A, Harrington L. IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis. Immunohorizons. 2019;3:194-202 pubmed publisher
Železnjak J, Lisnic V, Popovic B, Lisnić B, Babic M, Halenius A, et al. The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors. J Exp Med. 2019;: pubmed publisher
Walker J, Clark P, Crisp A, Barlow J, Szeto A, Ferreira A, et al. Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow. Immunity. 2019;: pubmed publisher
Melo Gonzalez F, Kammoun H, Evren E, Dutton E, Papadopoulou M, Bradford B, et al. Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria. J Exp Med. 2019;216:728-742 pubmed publisher
Yasuda K, Kitagawa Y, Kawakami R, Isaka Y, Watanabe H, Kondoh G, et al. Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation. Nat Commun. 2019;10:549 pubmed publisher
Zhang W, Li Q, Li D, Li J, Aki D, Liu Y. The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J Exp Med. 2018;215:3180-3193 pubmed publisher
Knolle M, Chin S, Rana B, Englezakis A, Nakagawa R, Fallon P, et al. MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity. Front Immunol. 2018;9:2232 pubmed publisher
Li Q, Li D, Zhang X, Wan Q, Zhang W, Zheng M, et al. E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor. Immunity. 2018;48:258-270.e5 pubmed publisher
Delpoux A, Michelini R, Verma S, Lai C, Omilusik K, Utzschneider D, et al. Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells. J Exp Med. 2018;215:575-594 pubmed publisher
Danahy D, Anthony S, Jensen I, Hartwig S, Shan Q, Xue H, et al. Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells. PLoS Pathog. 2017;13:e1006569 pubmed publisher
Taylor S, Huang Y, Mallett G, Stathopoulou C, Felizardo T, Sun M, et al. PD-1 regulates KLRG1+ group 2 innate lymphoid cells. J Exp Med. 2017;214:1663-1678 pubmed publisher
Huang R, Francois A, McGray A, Miliotto A, Odunsi K. Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer. Oncoimmunology. 2017;6:e1249561 pubmed publisher
Knudson K, Pritzl C, Saxena V, Altman A, Daniels M, Teixeiro E. NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality. Proc Natl Acad Sci U S A. 2017;114:E1659-E1667 pubmed publisher
Luu T, Ganesan S, Wagner A, Sarhan D, Meinke S, Garbi N, et al. Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells. Sci Rep. 2016;6:37996 pubmed publisher
Lewis G, Wehrens E, Labarta Bajo L, Streeck H, Zuniga E. TGF-? receptor maintains CD4 T helper cell identity during chronic viral infections. J Clin Invest. 2016;126:3799-3813 pubmed publisher
Menendez C, Jinkins J, Carr D. Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency. J Immunol. 2016;197:1262-75 pubmed publisher
Doorduijn E, Sluijter M, Querido B, Oliveira C, Achour A, Ossendorp F, et al. TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors. J Clin Invest. 2016;126:784-94 pubmed publisher
Mackay L, Wynne Jones E, Freestone D, Pellicci D, Mielke L, Newman D, et al. T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate. Immunity. 2015;43:1101-11 pubmed publisher
Pearce V, Bouabe H, MacQueen A, Carbonaro V, Okkenhaug K. PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes. J Immunol. 2015;195:3206-17 pubmed publisher
Miosge L, Field M, Sontani Y, Cho V, Johnson S, Palkova A, et al. Comparison of predicted and actual consequences of missense mutations. Proc Natl Acad Sci U S A. 2015;112:E5189-98 pubmed publisher
Kenney L, Cornberg M, Chen A, Emonet S, de la Torre J, Selin L. Increased Immune Response Variability during Simultaneous Viral Coinfection Leads to Unpredictability in CD8 T Cell Immunity and Pathogenesis. J Virol. 2015;89:10786-801 pubmed publisher
Walker J, Oliphant C, Englezakis A, Yu Y, Clare S, Rodewald H, et al. Bcl11b is essential for group 2 innate lymphoid cell development. J Exp Med. 2015;212:875-82 pubmed publisher
Martinet L, Ferrari de Andrade L, Guillerey C, Lee J, Liu J, Souza Fonseca Guimaraes F, et al. DNAM-1 expression marks an alternative program of NK cell maturation. Cell Rep. 2015;11:85-97 pubmed publisher
Berkley A, Fink P. Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation. J Immunol. 2014;193:3262-6 pubmed publisher
Boulet S, Daudelin J, Labrecque N. IL-2 induction of Blimp-1 is a key in vivo signal for CD8+ short-lived effector T cell differentiation. J Immunol. 2014;193:1847-54 pubmed publisher
Mahmud S, Manlove L, Schmitz H, Xing Y, Wang Y, Owen D, et al. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat Immunol. 2014;15:473-81 pubmed publisher
Kieckbusch J, Gaynor L, Moffett A, Colucci F. MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling. Nat Commun. 2014;5:3359 pubmed publisher
Keating R, Hertz T, Wehenkel M, Harris T, Edwards B, McClaren J, et al. The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus. Nat Immunol. 2013;14:1266-76 pubmed publisher
Fulton R, Weiss K, Pewe L, Harty J, Varga S. Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection. J Virol. 2013;87:12694-700 pubmed publisher
van Helden M, Zaiss D, Sijts A. CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice. PLoS ONE. 2012;7:e52027 pubmed publisher
Mizutani T, Neugebauer N, Putz E, Moritz N, Simma O, Zebedin Brandl E, et al. Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology. 2012;1:1027-1037 pubmed
Zhang N, Bevan M. TGF-? signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation. Nat Immunol. 2012;13:667-73 pubmed publisher
Wiesel M, Crouse J, Bedenikovic G, Sutherland A, Joller N, Oxenius A. Type-I IFN drives the differentiation of short-lived effector CD8+ T cells in vivo. Eur J Immunol. 2012;42:320-9 pubmed publisher
Fowler C, Pao L, Blattman J, Greenberg P. SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells. J Immunol. 2010;185:3256-67 pubmed publisher
Yewdall A, DRUTMAN S, Jinwala F, Bahjat K, Bhardwaj N. CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells. PLoS ONE. 2010;5:e11144 pubmed publisher
Wilson D, Grotenbreg G, Liu K, Zhao Y, Frickel E, Gubbels M, et al. Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells. PLoS Pathog. 2010;6:e1000815 pubmed publisher
Banh C, Fugere C, Brossay L. Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling. Blood. 2009;114:5299-306 pubmed publisher
Ito M, Maruyama T, Saito N, Koganei S, Yamamoto K, Matsumoto N. Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. J Exp Med. 2006;203:289-95 pubmed
product information
Product Type :
Antibody
Product Name :
KLRG1 Monoclonal Antibody (2F1), Functional Grade, eBioscience
Catalog # :
16-5893-050
Quantity :
50 mg
Price :
US 13750
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Syrian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent
Species :
Mouse
Clone :
2F1
Isotype :
IgG
Storage :
4° C
Description :
KLRG1 (Killer cell lectin-like receptor G1, MAFA, 2F1-Ag) is a homodimeric member of the lectin-like type 2 transmembrane receptor family whose members contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. KLRG1 is an inhibitory receptor that is expressed on natural killer (NK) cells and certain T cells. NK cells are involved in the lysis of tumor cells and virus-infected cells, and mediate humoral and cell-mediated immune responses.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent
Aliases :
2F1; 2F1-Ag; CLEC15A; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; ITIM-containing receptor MAFA-L; killer cell lectin like receptor G1; killer cell lectin-like receptor subfamily G member 1; killer cell lectin-like receptor subfamily G, member 1; Klrg1; Mafa; MAFA-2F1; MAFAL; MAFA-L; MAFA-LIKE; MAFA-like receptor; Mast cell function-associated antigen; mast cell function-associated antigen (ITIM-containing); mast cell function-associated antigen 2F1; natural killer cell receptor
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA