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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD275 (B7-H2) Monoclonal Antibody (MIH12), Functional Grade, eBioscience™
catalog :
16-5889-82
quantity :
100 µg
price :
319 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MIH12
reactivity :
human
application :
immunohistochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments, other
more info or order :
Invitrogen product webpage
citations: 28
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; 10 ug/ml; fig 6
Franzese O, Palermo B, Di Donna C, Sperduti I, Ferraresi V, Stabile H, et al. Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS. Oncoimmunology. 2016;5:e1114203 pubmed publisher
  • other; human; fig 4
Hu X, Liu C, An J, Shen Y, Hu Y, Jiang J, et al. Development of a Novel Functional Monoclonal Antibody to Human CD275: Characterization and Biological Activity. Monoclon Antib Immunodiagn Immunother. 2016;35:18-24 pubmed publisher
  • flow cytometry; human; 5 ug/ml
Quiroga M, Pasquinelli V, Martinez G, Jurado J, Zorrilla L, Musella R, et al. Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis. J Immunol. 2006;176:5965-74 pubmed
Roussel L, Landekic M, Golizeh M, Gavino C, Zhong M, Chen J, et al. Loss of human ICOSL results in combined immunodeficiency. J Exp Med. 2018;215:3151-3164 pubmed publisher
van der Tas J, Elfrink M, Heijboer A, Rivadeneira F, Jaddoe V, Tiemeier H, et al. Foetal, neonatal and child vitamin D status and enamel hypomineralization. Community Dent Oral Epidemiol. 2018;46:343-351 pubmed publisher
Ventura Ferreira M, Bienert M, Muller K, Rath B, Goecke T, Opländer C, et al. Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta. Stem Cell Res Ther. 2018;9:28 pubmed publisher
Pattarini L, Trichot C, Bogiatzi S, Grandclaudon M, Meller S, Keuylian Z, et al. TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand. J Exp Med. 2017;214:1529-1546 pubmed publisher
Sakthivel P, Grunewald J, Eklund A, Bruder D, Wahlström J. Pulmonary sarcoidosis is associated with high-level inducible co-stimulator (ICOS) expression on lung regulatory T cells--possible implications for the ICOS/ICOS-ligand axis in disease course and resolution. Clin Exp Immunol. 2016;183:294-306 pubmed publisher
Pedroza Gonzalez A, Zhou G, Vargas Mendez E, Boor P, Mancham S, Verhoef C, et al. Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors. Oncoimmunology. 2015;4:e1008355 pubmed
Wheway J, Latham S, Combes V, Grau G. Endothelial microparticles interact with and support the proliferation of T cells. J Immunol. 2014;193:3378-87 pubmed publisher
Nizzoli G, Krietsch J, Weick A, Steinfelder S, Facciotti F, Gruarin P, et al. Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses. Blood. 2013;122:932-42 pubmed publisher
Chen J, Wang F, Cai Q, Shen S, Chen Y, Hao C, et al. A novel anti-human ICOSL monoclonal antibody that enhances IgG production of B cells. Monoclon Antib Immunodiagn Immunother. 2013;32:125-31 pubmed publisher
Wheway J, Obeid S, Couraud P, Combes V, Grau G. The brain microvascular endothelium supports T cell proliferation and has potential for alloantigen presentation. PLoS ONE. 2013;8:e52586 pubmed publisher
Dölen Y, Esendagli G. Myeloid leukemia cells with a B7-2(+) subpopulation provoke Th-cell responses and become immuno-suppressive through the modulation of B7 ligands. Eur J Immunol. 2013;43:747-57 pubmed publisher
Frick S, Bacher N, Baier G, Mailänder V, Landfester K, Steinbrink K. Functionalized polystyrene nanoparticles trigger human dendritic cell maturation resulting in enhanced CD4+ T cell activation. Macromol Biosci. 2012;12:1637-47 pubmed publisher
Severa M, Giacomini E, Gafa V, Anastasiadou E, Rizzo F, Corazzari M, et al. EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: implications for viral immune escape. Eur J Immunol. 2013;43:147-58 pubmed publisher
Lichtenegger F, Mueller K, Otte B, Beck B, Hiddemann W, Schendel D, et al. CD86 and IL-12p70 are key players for T helper 1 polarization and natural killer cell activation by Toll-like receptor-induced dendritic cells. PLoS ONE. 2012;7:e44266 pubmed publisher
Castellaneta A, Mazariegos G, Nayyar N, Zeevi A, Thomson A. HLA-G level on monocytoid dendritic cells correlates with regulatory T-cell Foxp3 expression in liver transplant tolerance. Transplantation. 2011;91:1132-40 pubmed publisher
Kavousanaki M, Makrigiannakis A, Boumpas D, Verginis P. Novel role of plasmacytoid dendritic cells in humans: induction of interleukin-10-producing Treg cells by plasmacytoid dendritic cells in patients with rheumatoid arthritis responding to therapy. Arthritis Rheum. 2010;62:53-63 pubmed publisher
Nanki T, Takada K, Komano Y, Morio T, Kanegane H, Nakajima A, et al. Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis. Arthritis Res Ther. 2009;11:R149 pubmed publisher
Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, et al. Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol. 2009;182:5515-27 pubmed publisher
Wiesemann E, Deb M, Trebst C, Hemmer B, Stangel M, Windhagen A. Effects of interferon-beta on co-signaling molecules: upregulation of CD40, CD86 and PD-L2 on monocytes in relation to clinical response to interferon-beta treatment in patients with multiple sclerosis. Mult Scler. 2008;14:166-76 pubmed
Wang F, Zhu W, Liu T, Sun Z, Ju S, Yu G, et al. The expression analysis of ICOS-L on activated T cells and immature dendritic cells as well as malignant B cells and Grave's-disease-derived thyroid tissues by two novel mAbs against human ICOS-L. Tissue Antigens. 2007;69:62-72 pubmed
Chattopadhyay K, Bhatia S, Fiser A, Almo S, Nathenson S. Structural basis of inducible costimulator ligand costimulatory function: determination of the cell surface oligomeric state and functional mapping of the receptor binding site of the protein. J Immunol. 2006;177:3920-9 pubmed
Youngnak Piboonratanakit P, Tsushima F, Otsuki N, Igarashi H, Omura K, Azuma M. Expression and regulation of human CD275 on endothelial cells in healthy and inflamed mucosal tissues. Scand J Immunol. 2006;63:191-8 pubmed
Methe H, Nugent H, Groothuis A, Seifert P, Sayegh M, Edelman E. Matrix embedding alters the immune response against endothelial cells in vitro and in vivo. Circulation. 2005;112:I89-95 pubmed
Azam P, Peiffer J, Chamousset D, Tissier M, Bonnet P, Vian L, et al. The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers. Toxicol Appl Pharmacol. 2006;212:14-23 pubmed
Yang J, Zhang J, Cai Q, Zhao D, Wang J, Guo P, et al. Expression and function of inducible costimulator on peripheral blood T cells in patients with systemic lupus erythematosus. Rheumatology (Oxford). 2005;44:1245-54 pubmed
product information
Product Type :
Antibody
Product Name :
CD275 (B7-H2) Monoclonal Antibody (MIH12), Functional Grade, eBioscience™
Catalog # :
16-5889-82
Quantity :
100 µg
Price :
319 USD
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Neutralization: Assay-Dependent
Species :
Human
Clone :
MIH12
Isotype :
IgG1, kappa
Storage :
4° C
Description :
Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Neutralization: Assay-Dependent
Aliases :
AU044799; B7 homolog 2; B7 homologue 2; B7h; B7H2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP1; B7RP-1; BG071784; CD275; GI50; GL50; GL50-B; ICOS ligand; ICOSL; ICOS-L; ICOSLG; inducible T-cell costimulator ligand; inducible T-cell co-stimulator ligand; KIAA0653; LICOS; Ly115l; mKIAA0653; RGD1562791; transmembrane protein B7-H2 ICOS ligand
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA