CD357 (AITR/GITR) Monoclonal Antibody (DTA-1), Functional Grade, eBioscience | Invitrogen 16-5874-38 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD357 (AITR/GITR) Monoclonal Antibody (DTA-1), Functional Grade, eBioscience

catalog :

16-5874-38

quantity :

5 mg

price :

US 2570

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

DTA-1

reactivity :

mouse

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 25

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 3e	Wang Z, He L, Li W, Xu C, Zhang J, Wang D, et al. GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma. J Immunother Cancer. 2021;9: pubmed publisher
flow cytometry; mouse; loading ...	Gryzik S, Hoang Y, Lischke T, Mohr E, Venzke M, Kadner I, et al. Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception. elife. 2020;9: pubmed publisher
	Chen T, Hou X, Ni Y, Du W, Han H, Yu Y, et al. The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients. J Immunol Res. 2018;2018:3096183 pubmed publisher
	Liu Z, Hao X, Zhang Y, Zhang J, Carey C, Falo L, et al. Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist α-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity. Oncoimmunology. 2017;6:e1315487 pubmed publisher
	Ansa Addo E, Zhang Y, Yang Y, Hussey G, Howley B, Salem M, et al. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. J Clin Invest. 2017;127:1321-1337 pubmed publisher
	Wu C, Chen Z, Dardalhon V, Xiao S, Thalhamer T, Liao M, et al. The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program. Nat Immunol. 2017;18:344-353 pubmed publisher
	O Hagan K, Choi J, Pryshchep O, Chernoff J, Phee H. Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance. J Immunol. 2015;195:1564-77 pubmed publisher
	Pollizzi K, Waickman A, Patel C, Sun I, Powell J. Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition. PLoS ONE. 2015;10:e0121710 pubmed publisher
	Schmidt A, Lu W, Sindhava V, Huang Y, Burkhardt J, Yang E, et al. Regulatory T cells require TCR signaling for their suppressive function. J Immunol. 2015;194:4362-70 pubmed publisher
	Canavaci A, Sorgi C, Martins V, Morais F, de Sousa Ã, Trindade B, et al. The acute phase of Trypanosoma cruzi infection is attenuated in 5-lipoxygenase-deficient mice. Mediators Inflamm. 2014;2014:893634 pubmed publisher
	Nguyen T, Makhlouf N, Anthony B, Teague R, DiPaolo R. In vitro induced regulatory T cells are unique from endogenous regulatory T cells and effective at suppressing late stages of ongoing autoimmunity. PLoS ONE. 2014;9:e104698 pubmed publisher
	Mahmud S, Manlove L, Schmitz H, Xing Y, Wang Y, Owen D, et al. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat Immunol. 2014;15:473-81 pubmed publisher
	Schmidt A, Zou T, Joshi R, Leichner T, Pimentel M, Sommers C, et al. Diacylglycerol kinase ? limits the generation of natural regulatory T cells. Sci Signal. 2013;6:ra101 pubmed publisher
	Huang H, Ma Y, Dawicki W, Zhang X, Gordon J. Comparison of induced versus natural regulatory T cells of the same TCR specificity for induction of tolerance to an environmental antigen. J Immunol. 2013;191:1136-43 pubmed publisher
	Billiard F, Lobry C, Darrasse Jèze G, Waite J, Liu X, Mouquet H, et al. Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice. J Exp Med. 2012;209:1011-28 pubmed publisher
	Jhunjhunwala S, Balmert S, Raimondi G, Dons E, Nichols E, Thomson A, et al. Controlled release formulations of IL-2, TGF-?1 and rapamycin for the induction of regulatory T cells. J Control Release. 2012;159:78-84 pubmed publisher
	Takata M, Nakagomi T, Kashiwamura S, Nakano Doi A, Saino O, Nakagomi N, et al. Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke. Cell Death Differ. 2012;19:756-67 pubmed publisher
	Zhen Y, Sun L, Liu H, Duan K, Zeng C, Zhang L, et al. Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes. Cell Mol Immunol. 2012;9:75-85 pubmed publisher
	Satou Y, Yasunaga J, Zhao T, Yoshida M, Miyazato P, Takai K, et al. HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog. 2011;7:e1001274 pubmed publisher
	Gültner S, Kuhlmann T, Hesse A, Weber J, Riemer C, Baier M, et al. Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE. Eur J Immunol. 2010;40:3403-12 pubmed publisher
	Chen X, Hamano R, Subleski J, Hurwitz A, Howard O, Oppenheim J. Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells. J Immunol. 2010;185:174-82 pubmed publisher
	van Olffen R, Koning N, van Gisbergen K, Wensveen F, Hoek R, Boon L, et al. GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo. J Immunol. 2009;182:7490-500 pubmed publisher
	Marshall N, Vorachek W, Steppan L, Mourich D, Kerkvliet N. Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Immunol. 2008;181:2382-91 pubmed
	Chen X, Subleski J, Kopf H, Howard O, Männel D, Oppenheim J. Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells. J Immunol. 2008;180:6467-71 pubmed
	Vanoosten R, Griffith T. Activation of tumor-specific CD8+ T Cells after intratumoral Ad5-TRAIL/CpG oligodeoxynucleotide combination therapy. Cancer Res. 2007;67:11980-90 pubmed

product information

Product Type :

Antibody

Product Name :

CD357 (AITR/GITR) Monoclonal Antibody (DTA-1), Functional Grade, eBioscience

Catalog # :

16-5874-38

Quantity :

5 mg

Price :

US 2570

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.03 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): 10 µg/mL

Species :

Mouse

Clone :

DTA-1

Isotype :

IgG2b, kappa

Storage :

4° C

Description :

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.03 µg/test, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): 10 µg/mL

Aliases :

Activation-inducible TNFR family receptor; AITR; CD357; GITR; GITR-D; glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; TNF receptor superfamily member 18; TNFRSF18; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily, member 18; UNQ319; UNQ319/PRO364

more info or order :

Invitrogen product webpage