TCR gamma/delta Monoclonal Antibody (UC7-13D5), Functional Grade, eBioscience™ | Invitrogen 16-5811-85 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR gamma/delta Monoclonal Antibody (UC7-13D5), Functional Grade, eBioscience™

catalog :

16-5811-85

quantity :

500 µg

price :

329 USD

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

UC7-13D5

reactivity :

mouse

application :

flow cytometry, other

more info or order :

Invitrogen product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
other; mouse; fig s2a	Bruce D, Stefanski H, Vincent B, Dant T, Reisdorf S, Bommiasamy H, et al. Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease. J Clin Invest. 2017;127:1813-1825 pubmed publisher
flow cytometry; mouse; fig 5a	Lee J, Tato C, Joyce Shaikh B, Gulen M, Gulan F, Cayatte C, et al. Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability. Immunity. 2015;43:727-38 pubmed publisher
flow cytometry; mouse	Berent Maoz B, Montecino Rodriguez E, Fice M, Casero D, Seet C, Crooks G, et al. The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2). PLoS ONE. 2015;10:e0125414 pubmed publisher
flow cytometry; mouse	Blache C, Adriouch S, Calbo S, Drouot L, Dulauroy S, Arnoult C, et al. Cutting edge: CD4-independent development of functional FoxP3+ regulatory T cells. J Immunol. 2009;183:4182-6 pubmed publisher
	Choi M, Yi J, Kim S, Ryu J, Lee J, Kwon W, et al. Anti-inflammatory effects of a methanol extract of Dictamnus dasycarpus Turcz. root bark on imiquimod-induced psoriasis. BMC Complement Altern Med. 2019;19:347 pubmed publisher
	Webster B, Werneke S, Zafirova B, This S, Coléon S, Decembre E, et al. Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses. elife. 2018;7: pubmed publisher
	Wunderlich C, Ackermann P, Ostermann A, Adams Quack P, Vogt M, Tran M, et al. Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment. Nat Commun. 2018;9:1646 pubmed publisher
	Kim H, Jang S, Lee W, Kim K, Sohn H, Hwang S, et al. PTEN drives Th17 cell differentiation by preventing IL-2 production. J Exp Med. 2017;214:3381-3398 pubmed publisher
	Noto Llana M, Sarnacki S, Morales A, Aya Castañeda M, Giacomodonato M, Blanco G, et al. Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells. Front Cell Infect Microbiol. 2017;7:398 pubmed publisher
	Kim J, Choi Y, Lee B, Song M, Ban C, Kim J, et al. Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells. J Allergy Clin Immunol. 2016;137:1466-1476.e3 pubmed publisher
	Marquis M, Daudelin J, Boulet S, Sirois J, Crain K, Mathien S, et al. The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival. Mol Cell Biol. 2014;34:3374-87 pubmed publisher
	Berent Maoz B, Montecino Rodriguez E, Signer R, Dorshkind K. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood. 2012;119:5715-21 pubmed publisher
	Li Z, Zhang C, Zhou Z, Zhang J, Zhang J, Tian Z. Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor ?? are involved in bacterial clearance during Salmonella enterica serovar Typhimurium infection. Infect Immun. 2012;80:565-74 pubmed publisher
	Koenecke C, Chennupati V, Schmitz S, Malissen B, Forster R, Prinz I. In vivo application of mAb directed against the gammadelta TCR does not deplete but generates "invisible" gammadelta T cells. Eur J Immunol. 2009;39:372-9 pubmed publisher
	Dupré S, Redelman D, Hunter K. Microenvironment of the murine mammary carcinoma 4T1: endogenous IFN-gamma affects tumor phenotype, growth, and metastasis. Exp Mol Pathol. 2008;85:174-88 pubmed publisher
	Roark C, Aydintug M, Lewis J, Yin X, Lahn M, Hahn Y, et al. Subset-specific, uniform activation among V gamma 6/V delta 1+ gamma delta T cells elicited by inflammation. J Leukoc Biol. 2004;75:68-75 pubmed
	Usami J, Hiromatsu K, Matsumoto Y, Maeda K, Inagaki H, Suzuki T, et al. A protective role of gamma delta T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice. Immunology. 1995;86:199-205 pubmed
	Kakkanaiah V, Nagarkatti M, Bluestone J, Nagarkatti P. CD4-CD8- thymocytes from MRL-lpr/lpr mice exhibit abnormal proportions of alpha beta- and gamma delta-TCR+ cells and demonstrate defective responsiveness when activated through the TCR. Cell Immunol. 1991;137:269-82 pubmed
	Taguchi T, Aicher W, Fujihashi K, Yamamoto M, McGhee J, Bluestone J, et al. Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5. J Immunol. 1991;147:3736-44 pubmed
	Bluestone J, Cron R, Barrett T, Houlden B, Sperling A, Dent A, et al. Repertoire development and ligand specificity of murine TCR gamma delta cells. Immunol Rev. 1991;120:5-33 pubmed

product information

Product Type :

Antibody

Product Name :

TCR gamma/delta Monoclonal Antibody (UC7-13D5), Functional Grade, eBioscience™

Catalog # :

16-5811-85

Quantity :

500 µg

Price :

329 USD

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent

Species :

Mouse

Clone :

UC7-13D5

Isotype :

IgG

Storage :

4° C

Description :

TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent

Aliases :

T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@

more info or order :

Invitrogen product webpage