TSLP Monoclonal Antibody (eBio28F12 (28F12)), Functional Grade, eBioscience | Invitrogen 16-5491-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TSLP Monoclonal Antibody (eBio28F12 (28F12)), Functional Grade, eBioscience

catalog :

16-5491-82

quantity :

100 ug

price :

US 157.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

eBio28F12 (28F12)

reactivity :

mouse

application :

neutralization

citations: 7

Reference
Huang F, Ma Y, Tang R, Gong W, Li J, Chen C, et al. Interleukin-4- and NACHT, LRR and PYD domains-containing protein 3-independent mechanisms of alum enhanced T helper type 2 responses on basophils. Immunology. 2016;149:238-51 pubmed publisher
Marshall N, Lukomska E, Long C, Kashon M, Sharpnack D, Nayak A, et al. Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses. Toxicol Sci. 2015;147:127-39 pubmed publisher
Rajavelu P, Chen G, Xu Y, Kitzmiller J, Korfhagen T, Whitsett J. Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation. J Clin Invest. 2015;125:2021-31 pubmed publisher
Cipolat S, Hoste E, Natsuga K, Quist S, Watt F. Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility. elife. 2014;3:e01888 pubmed publisher
Demehri S, Morimoto M, Holtzman M, Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol. 2009;7:e1000067 pubmed publisher
Taylor B, Zaph C, Troy A, Du Y, Guild K, Comeau M, et al. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J Exp Med. 2009;206:655-67 pubmed publisher
Zhou B, Headley M, Aye T, Tocker J, Comeau M, Ziegler S. Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of Th2 responses. J Immunol. 2008;181:6557-62 pubmed

product information

Product Type :

Antibody

Product Name :

TSLP Monoclonal Antibody (eBio28F12 (28F12)), Functional Grade, eBioscience

Catalog # :

16-5491-82

Quantity :

100 ug

Price :

US 157.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Mouse

Clone :

eBio28F12 (28F12)

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.

Format :

Liquid

Applications w/Dilutions :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

Thymic stroma-derived lymphopoietin; thymic stromal lymphopoietin; TSLP