TSLP Monoclonal Antibody (eBio28F12 (28F12)), Functional Grade, eBioscience | Invitrogen 16-5491-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TSLP Monoclonal Antibody (eBio28F12 (28F12)), Functional Grade, eBioscience

catalog :

16-5491-025

quantity :

25 mg

price :

US 8250

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

eBio28F12 (28F12)

reactivity :

mouse

application :

neutralization

citations: 4

Reference
Huang F, Ma Y, Tang R, Gong W, Li J, Chen C, et al. Interleukin-4- and NACHT, LRR and PYD domains-containing protein 3-independent mechanisms of alum enhanced T helper type 2 responses on basophils. Immunology. 2016;149:238-51 pubmed publisher
Marshall N, Lukomska E, Long C, Kashon M, Sharpnack D, Nayak A, et al. Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses. Toxicol Sci. 2015;147:127-39 pubmed publisher
Rajavelu P, Chen G, Xu Y, Kitzmiller J, Korfhagen T, Whitsett J. Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation. J Clin Invest. 2015;125:2021-31 pubmed publisher
Cipolat S, Hoste E, Natsuga K, Quist S, Watt F. Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility. elife. 2014;3:e01888 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TSLP Monoclonal Antibody (eBio28F12 (28F12)), Functional Grade, eBioscience

Catalog # :

16-5491-025

Quantity :

25 mg

Price :

US 8250

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Mouse

Clone :

eBio28F12 (28F12)

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.

Format :

Liquid

Applications w/Dilutions :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

Thymic stroma-derived lymphopoietin; thymic stromal lymphopoietin; TSLP