CD85d (ILT4) Monoclonal Antibody (42D1), Functional Grade, eBioscience™ | Invitrogen 16-5149-85 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD85d (ILT4) Monoclonal Antibody (42D1), Functional Grade, eBioscience™

catalog :

16-5149-85

quantity :

500 µg

price :

US 469

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

42D1

reactivity :

human

application :

flow cytometry, immunohistochemistry - paraffin section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 10 ug/ml; loading ...; fig s4j immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 1a	Zhao P, Xu Y, Jiang L, Fan X, Ku Z, Li L, et al. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Mol Neurodegener. 2022;17:44 pubmed publisher
	Waschbisch A, SchrÃ¶der S, Schraudner D, Sammet L, Weksler B, Melms A, et al. Pivotal Role for CD16+ Monocytes in Immune Surveillance of the Central Nervous System. J Immunol. 2016;196:1558-67 pubmed publisher
	Deng M, Lu Z, Zheng J, Wan X, Chen X, Hirayasu K, et al. A motif in LILRB2 critical for Angptl2 binding and activation. Blood. 2014;124:924-35 pubmed publisher
	Dokić J, Tomic S, Markovic M, Milosavljević P, Colic M. Mesenchymal stem cells from periapical lesions modulate differentiation and functional properties of monocyte-derived dendritic cells. Eur J Immunol. 2013;43:1862-72 pubmed publisher
	Banchereau J, Zurawski S, Thompson Snipes L, Blanck J, Clayton S, Munk A, et al. Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming. Proc Natl Acad Sci U S A. 2012;109:18885-90 pubmed publisher
	Maloveste S, Chen D, Gostick E, Vivian J, Plishka R, Iyengar R, et al. Degenerate recognition of MHC class I molecules with Bw4 and Bw6 motifs by a killer cell Ig-like receptor 3DL expressed by macaque NK cells. J Immunol. 2012;189:4338-48 pubmed publisher
	Zheng J, Umikawa M, Cui C, Li J, Chen X, Zhang C, et al. Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature. 2012;485:656-60 pubmed publisher
	Jensen M, Yanowitch R, Reder A, White D, Arnason B. Immunoglobulin-like transcript 3, an inhibitor of T cell activation, is reduced on blood monocytes during multiple sclerosis relapses and is induced by interferon beta-1b. Mult Scler. 2010;16:30-8 pubmed publisher
	Allan D, Colonna M, Lanier L, Churakova T, Abrams J, Ellis S, et al. Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells. J Exp Med. 1999;189:1149-56 pubmed
	Colonna M, Samaridis J, Cella M, Angman L, Allen R, O Callaghan C, et al. Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J Immunol. 1998;160:3096-100 pubmed

product information

Product Type :

Antibody

Product Name :

CD85d (ILT4) Monoclonal Antibody (42D1), Functional Grade, eBioscience™

Catalog # :

16-5149-85

Quantity :

500 µg

Price :

US 469

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human

Applications :

Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent

Species :

Human

Clone :

42D1

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

LILRB2 (ILT4) gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent

Aliases :

CD85 antigen-like family member D; CD85D; CD85d antigen; Ig-like transcript 4; ILT4; ILT-4; leucocyte Ig-like receptor B2; leukocyte immunoglobulin like receptor B2; leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; LILRB2; LIR2; LIR-2; LIR2CD85D; MIR10; MIR-10; MIR10LILRA6; monocyte/macrophage immunoglobulin-like receptor 10; myeloid inhibitory receptor 10

more info or order :

Invitrogen product webpage