CD85j (ILT2) Monoclonal Antibody (HP-F1), Functional Grade, eBioscience™ | Invitrogen 16-5129-38 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD85j (ILT2) Monoclonal Antibody (HP-F1), Functional Grade, eBioscience™

catalog :

16-5129-38

quantity :

5 mg

price :

US 2885

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HP-F1

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2b	Altvater B, Kailayangiri S, Pérez Lanuza L, Urban K, Greune L, Flügge M, et al. HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells. Cancers (Basel). 2021;13: pubmed publisher
	Kailayangiri S, Altvater B, Spurny C, Jamitzky S, Schelhaas S, Jacobs A, et al. Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G. Oncoimmunology. 2017;6:e1250050 pubmed publisher
	Cheent K, Jamil K, Cassidy S, Liu M, Mbiribindi B, Mulder A, et al. Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94. Proc Natl Acad Sci U S A. 2013;110:16981-6 pubmed publisher
	Maloveste S, Chen D, Gostick E, Vivian J, Plishka R, Iyengar R, et al. Degenerate recognition of MHC class I molecules with Bw4 and Bw6 motifs by a killer cell Ig-like receptor 3DL expressed by macaque NK cells. J Immunol. 2012;189:4338-48 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD85j (ILT2) Monoclonal Antibody (HP-F1), Functional Grade, eBioscience™

Catalog # :

16-5129-38

Quantity :

5 mg

Price :

US 2885

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.125 µg/test, Functional assay: Assay-Dependent

Species :

Human

Clone :

HP-F1

Isotype :

IgG1, kappa

Storage :

4° C

Description :

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 µg/test, Functional assay: Assay-Dependent

Aliases :

CD85 antigen-like family member J; CD85j; Ig-like transcript 2; ILT2; ILT-2; Immunoglobulin-like transcript 2; leucocyte Ig-like receptor B1; leukocyte immunoglobulin like receptor B1; leukocyte immunoglobulin-like receptor subfamily B member 1; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; leukocyte immunoglobulin-like receptor subfamily B member 3-like; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; LILRB1; LIR1; LIR-1; LOC100912456; MIR7; MIR-7; Monocyte/macrophage immunoglobulin-like receptor 7; myeloid inhibitory receptor 7; PIRB; PIR-B

more info or order :

Invitrogen product webpage