This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD335 (NKp46) Monoclonal Antibody (29A1.4), Functional Grade, eBioscience
catalog :
16-3351-025
quantity :
25 mg
price :
US 8250
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
29A1.4
reactivity :
mouse
application :
flow cytometry
citations: 50
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...
Piersma S, Poursine Laurent J, Yang L, Barber G, Parikh B, Yokoyama W. Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1d
Tizian C, Lahmann A, Hölsken O, Cosovanu C, Kofoed Branzk M, Heinrich F, et al. c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells. elife. 2020;9: pubmed publisher
Su Y, Huang H, Luo T, Zheng Y, Fan J, Ren H, et al. Cell-in-cell structure mediates in-cell killing suppressed by CD44. Cell Discov. 2022;8:35 pubmed publisher
Sobecki M, Krzywinska E, Nagarajan S, Audig xe9 A, Hu x1ef3 nh K, Zacharjasz J, et al. NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence. Nat Commun. 2021;12:4700 pubmed publisher
Cho S, Rudloff I, Lao J, Pang M, Goldberg R, Bui C, et al. Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities. Nat Commun. 2020;11:5794 pubmed publisher
Wang S, Qu Y, Xia P, Chen Y, Zhu X, Zhang J, et al. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. Cell Res. 2020;30:610-622 pubmed publisher
Park M, Kim H, Lee H, Zabel B, Bae Y. Novel CD11b+Gr-1+Sca-1+ myeloid cells drive mortality in bacterial infection. Sci Adv. 2020;6:eaax8820 pubmed publisher
Ronin E, Lubrano Di Ricco M, Vallion R, Divoux J, Kwon H, Gr xe9 goire S, et al. The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability. Front Immunol. 2019;10:2487 pubmed publisher
Zhang X, Feng J, Chen S, Yang H, Dong Z. Synergized regulation of NK cell education by NKG2A and specific Ly49 family members. Nat Commun. 2019;10:5010 pubmed publisher
Sifuentes Dominguez L, Li H, Llano E, Liu Z, Singla A, Patel A, et al. SCGN deficiency results in colitis susceptibility. elife. 2019;8: pubmed publisher
Poholek C, Dulson S, Zajac A, Harrington L. IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis. Immunohorizons. 2019;3:194-202 pubmed publisher
Železnjak J, Lisnic V, Popovic B, Lisnić B, Babic M, Halenius A, et al. The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors. J Exp Med. 2019;: pubmed publisher
Melo Gonzalez F, Kammoun H, Evren E, Dutton E, Papadopoulou M, Bradford B, et al. Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria. J Exp Med. 2019;216:728-742 pubmed publisher
Parigi S, Czarnewski P, Das S, Steeg C, Brockmann L, Fernandez Gaitero S, et al. Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo. Sci Rep. 2018;8:154 pubmed publisher
Kostrzewski T, Borg A, Meng Y, Filipovic I, Male V, Wack A, et al. Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development. J Immunol. 2018;200:1370-1381 pubmed publisher
Kortlever R, Sodir N, Wilson C, Burkhart D, Pellegrinet L, Brown Swigart L, et al. Myc Cooperates with Ras by Programming Inflammation and Immune Suppression. Cell. 2017;171:1301-1315.e14 pubmed publisher
Krzywinska E, Kantari Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, et al. Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis. Nat Commun. 2017;8:1597 pubmed publisher
Pyle C, Uwadiae F, Swieboda D, Harker J. Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology. PLoS Pathog. 2017;13:e1006640 pubmed publisher
Cuff A, Male V. Conventional NK cells and ILC1 are partially ablated in the livers of Ncr1 iCreTbx21 fl/fl mice. Wellcome Open Res. 2017;2:39 pubmed publisher
Miletić A, Lenartic M, Popovic B, Brizic I, Trsan T, Miklic K, et al. NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation. Eur J Immunol. 2017;47:1443-1456 pubmed publisher
Xia P, Liu J, Wang S, Ye B, Du Y, Xiong Z, et al. WASH maintains NKp46+ ILC3 cells by promoting AHR expression. Nat Commun. 2017;8:15685 pubmed publisher
Lagumersindez Denis N, Wrzos C, Mack M, Winkler A, van der Meer F, Reinert M, et al. Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathol. 2017;134:15-34 pubmed publisher
Albershardt T, Campbell D, Parsons A, Slough M, Ter Meulen J, Berglund P. LV305, a dendritic cell-targeting integration-deficient ZVex(TM)-based lentiviral vector encoding NY-ESO-1, induces potent anti-tumor immune response. Mol Ther Oncolytics. 2016;3:16010 pubmed publisher
Yang M, Chen S, Du J, He J, Wang Y, Li Z, et al. NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. Nat Commun. 2016;7:12730 pubmed publisher
Chow K, Delconte R, Huntington N, Tarlinton D, Sutherland R, Zhan Y, et al. Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells. J Immunol. 2016;197:2000-8 pubmed publisher
Brown A, Yang C, Fung K, Bachem A, Bourges D, Bedoui S, et al. Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen. PLoS Pathog. 2016;12:e1005691 pubmed publisher
Brandstätter O, Schanz O, Vorac J, König J, Mori T, Maruyama T, et al. Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor. Sci Rep. 2016;6:26091 pubmed publisher
Wilson K, Goding S, Neely H, Harris K, Antony P. Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells. Oncoimmunology. 2015;4:e1019196 pubmed
Aparicio Domingo P, Romera Hernandez M, Karrich J, Cornelissen F, Papazian N, Lindenbergh Kortleve D, et al. Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage. J Exp Med. 2015;212:1783-91 pubmed publisher
Krneta T, Gillgrass A, Chew M, Ashkar A. The breast tumor microenvironment alters the phenotype and function of natural killer cells. Cell Mol Immunol. 2016;13:628-39 pubmed publisher
Gumbleton M, Vivier E, Kerr W. SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice. J Immunol. 2015;194:2847-54 pubmed publisher
Marcondes A, Karoopongse E, Lesnikova M, Margineantu D, Welte T, Dinarello C, et al. α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics. Blood. 2014;124:2881-91 pubmed publisher
De Luca A, Carvalho A, Cunha C, Iannitti R, Pitzurra L, Giovannini G, et al. IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis. PLoS Pathog. 2013;9:e1003486 pubmed publisher
Mielke L, Jones S, Raverdeau M, Higgs R, Stefanska A, Groom J, et al. Retinoic acid expression associates with enhanced IL-22 production by ?? T cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med. 2013;210:1117-24 pubmed publisher
Lewis N, Haxhinasto S, Anderson S, Stefanopoulos D, Fogal S, Adusumalli P, et al. Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3. J Immunol. 2013;190:3533-40 pubmed publisher
van Helden M, Zaiss D, Sijts A. CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice. PLoS ONE. 2012;7:e52027 pubmed publisher
Mizutani T, Neugebauer N, Putz E, Moritz N, Simma O, Zebedin Brandl E, et al. Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology. 2012;1:1027-1037 pubmed
Bezman N, Kim C, Sun J, Min oo G, Hendricks D, Kamimura Y, et al. Molecular definition of the identity and activation of natural killer cells. Nat Immunol. 2012;13:1000-9 pubmed publisher
van Helden M, de Graaf N, Boog C, Topham D, Zaiss D, Sijts A. The bone marrow functions as the central site of proliferation for long-lived NK cells. J Immunol. 2012;189:2333-7 pubmed publisher
Ota N, Wong K, Valdez P, Zheng Y, Crellin N, Diehl L, et al. IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium. Nat Immunol. 2011;12:941-8 pubmed publisher
Lee I, van den Elzen P, Tan R, Priatel J. NKT cells are required for complete Freund's adjuvant-mediated protection from autoimmune diabetes. J Immunol. 2011;187:2898-904 pubmed publisher
Mauti L, Le Bitoux M, Baumer K, Stehle J, Golshayan D, Provero P, et al. Myeloid-derived suppressor cells are implicated in regulating permissiveness for tumor metastasis during mouse gestation. J Clin Invest. 2011;121:2794-807 pubmed publisher
Eckelhart E, Warsch W, Zebedin E, Simma O, Stoiber D, Kolbe T, et al. A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development. Blood. 2011;117:1565-73 pubmed publisher
Savan R, McFarland A, Reynolds D, Feigenbaum L, Ramakrishnan K, Karwan M, et al. A novel role for IL-22R1 as a driver of inflammation. Blood. 2011;117:575-84 pubmed publisher
Elliott J, Wahle J, Yokoyama W. MHC class I-deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I-sufficient environment. J Exp Med. 2010;207:2073-9 pubmed publisher
Haeberlein S, Sebald H, Bogdan C, Schleicher U. IL-18, but not IL-15, contributes to the IL-12-dependent induction of NK-cell effector functions by Leishmania infantum in vivo. Eur J Immunol. 2010;40:1708-17 pubmed publisher
Xie Y, Akpinarli A, Maris C, Hipkiss E, Lane M, Kwon E, et al. Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma. J Exp Med. 2010;207:651-67 pubmed publisher
White D, Keppel C, Schneider S, Reese T, Coder J, Payton J, et al. Latent herpesvirus infection arms NK cells. Blood. 2010;115:4377-83 pubmed publisher
Satoh Takayama N, Dumoutier L, Lesjean Pottier S, Ribeiro V, Mandelboim O, Renauld J, et al. The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium. J Immunol. 2009;183:6579-87 pubmed publisher
Cai S, Fehniger T, Cao X, Mayer J, Brune J, French A, et al. Differential expression of granzyme B and C in murine cytotoxic lymphocytes. J Immunol. 2009;182:6287-97 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD335 (NKp46) Monoclonal Antibody (29A1.4), Functional Grade, eBioscience
Catalog # :
16-3351-025
Quantity :
25 mg
Price :
US 8250
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent
Species :
Mouse
Clone :
29A1.4
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
NKp46 (CD335, NCR1, ) is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. NKp46 consists of two Ig-like domains assembled to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR).
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent
Aliases :
1-Mar; activating receptor 1; Ar1; CD335; hNKp46; Kilr1; KILR-1; LY94; Ly-94; lymphocyte antigen 94; Lymphocyte antigen 94 homolog; lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); mAR-1; MAR1 (mouse activating receptor 1); mNKp46; natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; natural killer cell receptor; Ncr1; NK cell-activating receptor; NK receptor KILR-1; NKACTR; Nkp46; NK-p46; NK-p46); rAR-1; rat-activating receptor 1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA