This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD324 (E-Cadherin) Monoclonal Antibody (DECMA-1), Functional Grade, eBioscience
catalog :
16-3249-38
quantity :
5 mg
price :
US 3075.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
DECMA-1

The same clone is also sold as:
reactivity :
human, mouse, dogs
application :
immunocytochemistry, neutralization, flow cytometry
citations: 38
Reference
Paw M, Kusiak A, Nit K, Litewka J, Piejko M, Wnuk D, et al. Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis. BMC Med. 2023;21:412 pubmed publisher
Marshall A, Galea G, Copp A, Greene N. The surface ectoderm exhibits spatially heterogenous tension that correlates with YAP localisation during spinal neural tube closure in mouse embryos. Cells Dev. 2023;174:203840 pubmed publisher
Zhou H, Yun X, Shu Y, Xu K. Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition. Oncol Lett. 2023;25:101 pubmed publisher
Olde Hanhof C, Dilmen E, Yousef Yengej F, Latta F, Ammerlaan C, Schreurs J, et al. Differentiated mouse kidney tubuloids as a novel in vitro model to study collecting duct physiology. Front Cell Dev Biol. 2023;11:1086823 pubmed publisher
Zisis T, Brückner D, Brandstätter T, Siow W, D Alessandro J, Vollmar A, et al. Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration. Biophys J. 2022;121:44-60 pubmed publisher
Li L, Hu Y, Chen D, Zhu J, Bao W, Xu X, et al. CMTM5 inhibits the development of prostate cancer via the EGFR/PI3K/AKT signaling pathway. Mol Med Rep. 2022;25: pubmed publisher
He Z, Lei S, Liang F, Tan L, Zhang W, Xie L, et al. Low-Dose Albendazole Inhibits Epithelial-Mesenchymal Transition of Melanoma Cells by Enhancing Phosphorylated GSK-3β/Tyr216 Accumulation. J Oncol. 2021;2021:4475192 pubmed publisher
Hsu S, Chou L, Hong C, Chang M, Tsai C, Tian Y, et al. Crosstalk between E-Cadherin/β-Catenin and NF-κB Signaling Pathways: The Regulation of Host-Pathogen Interaction during Leptospirosis. Int J Mol Sci. 2021;22: pubmed publisher
Troitskaya O, Novak D, Nushtaeva A, Savinkova M, Varlamov M, Ermakov M, et al. EGFR Transgene Stimulates Spontaneous Formation of MCF7 Breast Cancer Cells Spheroids with Partly Loss of HER3 Receptor. Int J Mol Sci. 2021;22: pubmed publisher
Oyama N, Kawaguchi M, Itaka K, Kawakami S. Efficient Messenger RNA Delivery to the Kidney Using Renal Pelvis Injection in Mice. Pharmaceutics. 2021;13: pubmed publisher
Fujioka N, Kitabatake M, Ouji Sageshima N, Ibaraki T, Kumamoto M, Fujita Y, et al. Human Adipose-Derived Mesenchymal Stem Cells Ameliorate Elastase-Induced Emphysema in Mice by Mesenchymal-Epithelial Transition. Int J Chron Obstruct Pulmon Dis. 2021;16:2783-2793 pubmed publisher
Billings S, Myers N, Quiruz L, Cheng A. Opposing effects of Wnt/β-catenin signaling on epithelial and mesenchymal cell fate in the developing cochlea. Development. 2021;148: pubmed publisher
Zeng X, Liao H, Wang F. MicroRNA-384 inhibits nasopharyngeal carcinoma growth and metastasis via binding to Smad5 and suppressing the Wnt/β-catenin axis. Cytotechnology. 2021;73:203-215 pubmed publisher
Kim J, Mahiddine F, Kim G. Leptin Modulates the Metastasis of Canine Inflammatory Mammary Adenocarcinoma Cells Through Downregulation of Lysosomal Protective Protein Cathepsin A (CTSA). Int J Mol Sci. 2020;21: pubmed publisher
Ramovs V, Krotenberg Garcia A, Kreft M, Sonnenberg A. Integrin α3β1 Is a Key Regulator of Several Protumorigenic Pathways during Skin Carcinogenesis. J Invest Dermatol. 2020;: pubmed publisher
DIXON E, Maxim D, Halperin Kuhns V, Lane Harris A, Outeda P, Ewald A, et al. GDNF drives rapid tubule morphogenesis in a novel 3D in vitro model for ADPKD. J Cell Sci. 2020;133: pubmed publisher
Kim H, Takegahara N, Walsh M, Choi Y. CD44 Can Compensate for IgSF11 Deficiency by Associating with the Scaffold Protein PSD-95 during Osteoclast Differentiation. Int J Mol Sci. 2020;21: pubmed publisher
Vila Ellis L, Cain M, Hutchison V, Flodby P, Crandall E, Borok Z, et al. Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell. 2020;52:617-630.e6 pubmed publisher
Bornes L, van Scheppingen R, Beerling E, Schelfhorst T, Ellenbroek S, Seinstra D, et al. Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT. Cell Rep. 2019;29:2565-2569.e3 pubmed publisher
Malik V, Glaser L, Zimmer D, Velychko S, Weng M, Holzner M, et al. Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2. Nat Commun. 2019;10:3477 pubmed publisher
Tran K, Pietrzak S, Zaidan N, Siahpirani A, McCalla S, Zhou A, et al. Defining Reprogramming Checkpoints from Single-Cell Analyses of Induced Pluripotency. Cell Rep. 2019;27:1726-1741.e5 pubmed publisher
Flood B, Manils J, Nulty C, Flis E, Kenealy S, Barber G, et al. Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis. Oncogene. 2019;38:2658-2674 pubmed publisher
Ostrin E, Little D, Gerner Mauro K, Sumner E, Ríos Corzo R, Ambrosio E, et al. β-Catenin maintains lung epithelial progenitors after lung specification. Development. 2018;145: pubmed publisher
Chua C, Epsi N, Leung E, Xuan S, Lei M, Li B, et al. Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation. elife. 2018;7: pubmed publisher
Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian T, et al. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Cell Stem Cell. 2017;21:791-805.e9 pubmed publisher
Lyons Cohen M, Thomas S, Cook D, Nakano H. Precision-cut Mouse Lung Slices to Visualize Live Pulmonary Dendritic Cells. J Vis Exp. 2017;: pubmed publisher
Scheele C, Hannezo E, Muraro M, Zomer A, Langedijk N, van Oudenaarden A, et al. Identity and dynamics of mammary stem cells during branching morphogenesis. Nature. 2017;542:313-317 pubmed publisher
Wuidart A, Ousset M, Rulands S, Simons B, Van Keymeulen A, Blanpain C. Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells. Genes Dev. 2016;30:1261-77 pubmed publisher
Oren B, Urosevic J, Mertens C, Mora J, Guiu M, Gomis R, et al. Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis. J Pathol. 2016;239:274-85 pubmed publisher
Jackson S, Olufs Z, Tran K, Zaidan N, Sridharan R. Alternative Routes to Induced Pluripotent Stem Cells Revealed by Reprogramming of the Neural Lineage. Stem Cell Reports. 2016;6:302-11 pubmed publisher
Zheng X, Carstens J, Kim J, Scheible M, Kaye J, Sugimoto H, et al. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 2015;527:525-530 pubmed publisher
Chantzoura E, Skylaki S, Menendez S, Kim S, Johnsson A, Linnarsson S, et al. Reprogramming Roadblocks Are System Dependent. Stem Cell Reports. 2015;5:350-64 pubmed publisher
Lovisa S, LeBleu V, Tampe B, Sugimoto H, Vadnagara K, Carstens J, et al. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nat Med. 2015;21:998-1009 pubmed publisher
Liang S, Marti T, Dorn P, Froment L, Hall S, Berezowska S, et al. Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer. Cell Death Dis. 2015;6:e1824 pubmed publisher
Wang S, Wang B, Pan N, Fu L, Wang C, Song G, et al. Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons. Sci Rep. 2015;5:9232 pubmed publisher
Chua C, Shibata M, Lei M, Toivanen R, Barlow L, Bergren S, et al. Single luminal epithelial progenitors can generate prostate organoids in culture. Nat Cell Biol. 2014;16:951-61, 1-4 pubmed publisher
Bajwa A, Rosin D, Chrościcki P, Lee S, Dondeti K, Ye H, et al. Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury. J Am Soc Nephrol. 2015;26:908-25 pubmed publisher
Spencer H, Eastham A, Merry C, Southgate T, Perez Campo F, Soncin F, et al. E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells. Mol Biol Cell. 2007;18:2838-51 pubmed
product information
Product Type :
Antibody
Product Name :
CD324 (E-Cadherin) Monoclonal Antibody (DECMA-1), Functional Grade, eBioscience
Catalog # :
16-3249-38
Quantity :
5 mg
Price :
US 3075.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Canine, Human, Mouse
Applications :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent, Immunocytochemistry: 5 ug/mL, Neutralization: Assay-Dependent
Species :
Canine, Human, Mouse
Clone :
DECMA-1
Isotype :
IgG1, kappa
Storage :
4 C
Description :
E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent, Immunocytochemistry: 5 ug/mL, Neutralization: Assay-Dependent
Aliases :
AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA