CD317 (BST2, PDCA-1) Monoclonal Antibody (26F8), Functional Grade, eBioscience | Invitrogen 16-3179-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD317 (BST2, PDCA-1) Monoclonal Antibody (26F8), Functional Grade, eBioscience

catalog :

16-3179-80

quantity :

25 µg

price :

US 163

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

26F8

reactivity :

human

application :

immunocytochemistry, neutralization, flow cytometry

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; fig 6	Bego M, CÃ´tÃ© Ã, Aschman N, Mercier J, Weissenhorn W, Cohen Ã. Vpu Exploits the Cross-Talk between BST2 and the ILT7 Receptor to Suppress Anti-HIV-1 Responses by Plasmacytoid Dendritic Cells. PLoS Pathog. 2015;11:e1005024 pubmed publisher
flow cytometry; human; 1:200; fig s4	Adoro S, Cubillos Ruiz J, Chen X, Deruaz M, Vrbanac V, Song M, et al. IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection. Nat Commun. 2015;6:7562 pubmed publisher
	Heusinger E, Deppe K, Sette P, Krapp C, Kmiec D, Kluge S, et al. Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2. J Virol. 2018;92: pubmed publisher
	Li M, Wang P, Zheng Z, Hu K, Zhang M, Guan X, et al. Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E. Virology. 2017;510:67-75 pubmed publisher
	Kluge S, Mack K, Iyer S, Pujol F, Heigele A, Learn G, et al. Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin. Cell Host Microbe. 2014;16:639-50 pubmed publisher
	Tavano B, Galao R, Graham D, Neil S, Aquino V, Fuchs D, et al. Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes. J Immunol. 2013;190:2622-30 pubmed publisher
	Davidson S, Kaiko G, Loh Z, Lalwani A, Zhang V, Spann K, et al. Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway. J Immunol. 2011;186:5938-48 pubmed publisher
	Miyagi E, Andrew A, Kao S, Strebel K. Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion. Proc Natl Acad Sci U S A. 2009;106:2868-73 pubmed publisher
	Van Damme N, Goff D, Katsura C, Jorgenson R, Mitchell R, Johnson M, et al. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe. 2008;3:245-52 pubmed publisher
	Neil S, Zang T, Bieniasz P. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature. 2008;451:425-30 pubmed publisher
	Ishikawa J, Kaisho T, Tomizawa H, Lee B, Kobune Y, Inazawa J, et al. Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics. 1995;26:527-34 pubmed

product information

Product Type :

Antibody

Product Name :

CD317 (BST2, PDCA-1) Monoclonal Antibody (26F8), Functional Grade, eBioscience

Catalog # :

16-3179-80

Quantity :

25 µg

Price :

US 163

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.125 µg/test, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Human

Clone :

26F8

Isotype :

IgG1, kappa

Storage :

4° C

Description :

BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein that is involved in the development and growth of B-cells. The surface expression of BST2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level), and myeloma cells. Research studies have shown that BST2 also functions as an inhibitor of retrovirus release from human cells whose activity is antagonized by the HIV-1 accessory protein, Vpu. While BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release, an activity that may represent a potential therapeutic strategy for the treatment of HIV/AIDS. Another disease associated with BST2 dysfunction is stomatitis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 µg/test, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

2310015I10Rik; bone marrow stromal antigen 2; bone marrow stromal cell antigen 2; Bst2; BST-2; C87040; CD317; Damp1; DAMP-1; DAMP-1 protein homolog; GREG; HM1.24 antigen; NPC-A-7; PDCA-1; protein DAMP-1; TETHERIN