product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD317 (BST2, PDCA-1) Monoclonal Antibody (eBio927), Functional Grade, eBioscienceâ„¢
catalog :
16-3172-85
quantity :
500 µg
price :
US 442
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
eBio927
reactivity :
mouse
application :
flow cytometry, other, mass cytometry
more info or order :
citations: 47
Published Application/Species/Sample/DilutionReference
  • mass cytometry; mouse; loading ...; fig 5d
Martinez L, Garcia G, Contreras D, Gong D, Sun R, Arumugaswami V. Zika Virus Mucosal Infection Provides Protective Immunity. J Virol. 2020;94: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6c
Bell O, Copland D, Ward A, Nicholson L, Lange C, Chu C, et al. Single Eye mRNA-Seq Reveals Normalisation of the Retinal Microglial Transcriptome Following Acute Inflammation. Front Immunol. 2019;10:3033 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1
Ko Y, Chan Y, Liu C, Liang J, Chuang T, Hsueh Y, et al. Blimp-1-Mediated Pathway Promotes Type I IFN Production in Plasmacytoid Dendritic Cells by Targeting to Interleukin-1 Receptor-Associated Kinase M. Front Immunol. 2018;9:1828 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Durai V, Bagadia P, Briseño C, Theisen D, Iwata A, Davidson J, et al. Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice. J Exp Med. 2018;215:1417-1435 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6c
Briseño C, Gargaro M, Durai V, Davidson J, Theisen D, Anderson D, et al. Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms. Proc Natl Acad Sci U S A. 2017;114:3957-3962 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b
Kretzer N, Theisen D, Tussiwand R, Briseño C, Grajales Reyes G, Wu X, et al. RAB43 facilitates cross-presentation of cell-associated antigens by CD8?+ dendritic cells. J Exp Med. 2016;213:2871-2883 pubmed
  • flow cytometry; mouse; fig s1c
Lenac Rovis T, Kucan Brlic P, Kaynan N, Juranic Lisnic V, Brizic I, Jordan S, et al. Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection. J Exp Med. 2016;213:1835-50 pubmed publisher
  • flow cytometry; mouse
Dahlgren M, Gustafsson Hedberg T, Livingston M, Cucak H, Alsén S, Yrlid U, et al. T follicular helper, but not Th1, cell differentiation in the absence of conventional dendritic cells. J Immunol. 2015;194:5187-99 pubmed publisher
  • flow cytometry; mouse
Sullivan B, Teijaro J, de la Torre J, Oldstone M. Early virus-host interactions dictate the course of a persistent infection. PLoS Pathog. 2015;11:e1004588 pubmed publisher
  • flow cytometry; mouse; fig 3
Fahl S, Harris B, Coffey F, Wiest D. Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint. J Immunol. 2015;194:200-9 pubmed
  • flow cytometry; mouse; fig 7a
Wu X, Satpathy A, Kc W, Liu P, Murphy T, Murphy K. Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo. PLoS ONE. 2013;8:e64800 pubmed publisher
  • other; mouse
Triozzi P, Aldrich W, Ponnazhagan S. Inhibition and promotion of tumor growth with adeno-associated virus carcinoembryonic antigen vaccine and Toll-like receptor agonists. Cancer Gene Ther. 2011;18:850-8 pubmed publisher
  • flow cytometry; mouse; fig 3
Charles E, Joshi S, Ash J, Fox B, Farris A, Bzik D, et al. CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infect Immun. 2010;78:3484-92 pubmed publisher
Hoffman R, Huang S, Chalasani G, Vallejo A. Disparate Recruitment and Retention of Plasmacytoid Dendritic Cells to The Small Intestinal Mucosa between Young and Aged Mice. Aging Dis. 2021;12:1183-1196 pubmed publisher
Wu J, Li S, Li T, Lv X, Zhang M, Zang G, et al. pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG. J Immunol Res. 2019;2019:1749803 pubmed publisher
Chopin M, Lun A, Zhan Y, Schreuder J, Coughlan H, D Amico A, et al. Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT. Immunity. 2019;50:77-90.e5 pubmed publisher
Dubrot J, Durães F, Harlé G, Schlaeppi A, Brighouse D, Madelon N, et al. Absence of MHC-II expression by lymph node stromal cells results in autoimmunity. Life Sci Alliance. 2018;1:e201800164 pubmed publisher
Humblet Baron S, Barber J, Roca C, Lenaerts A, Koni P, Liston A. Murine myeloproliferative disorder as a consequence of impaired collaboration between dendritic cells and CD4 T cells. Blood. 2018;: pubmed publisher
Giles D, Duncker P, Wilkinson N, Washnock Schmid J, Segal B. CNS-resident classical DCs play a critical role in CNS autoimmune disease. J Clin Invest. 2018;128:5322-5334 pubmed publisher
Tomasello E, Naciri K, Chelbi R, Bessou G, Fries A, Gressier E, et al. Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection. EMBO J. 2018;37: pubmed publisher
Harker J, Wong K, Dallari S, Bao P, Dolgoter A, Jo Y, et al. Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. J Virol. 2018;92: pubmed publisher
Manni M, Gupta S, Ricker E, Chinenov Y, Park S, Shi M, et al. Regulation of age-associated B cells by IRF5 in systemic autoimmunity. Nat Immunol. 2018;19:407-419 pubmed publisher
Lee Y, Lee J, Jang Y, Seo S, Chang J, Seong B. Non-specific Effect of Vaccines: Immediate Protection against Respiratory Syncytial Virus Infection by a Live Attenuated Influenza Vaccine. Front Microbiol. 2018;9:83 pubmed publisher
Shrestha B, You D, Saravia J, Siefker D, Jaligama S, Lee G, et al. IL-4R? on dendritic cells in neonates and Th2 immunopathology in respiratory syncytial virus infection. J Leukoc Biol. 2017;102:153-161 pubmed publisher
Schuh E, Musumeci A, Thaler F, Laurent S, Ellwart J, Hohlfeld R, et al. Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement. J Immunol. 2017;198:3081-3088 pubmed publisher
van Nieuwenhuijze A, Dooley J, Humblet Baron S, Sreenivasan J, Koenders M, Schlenner S, et al. Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice. Cell Mol Life Sci. 2017;74:2095-2106 pubmed publisher
Oh J, Lee M, Kim Y, Lee H. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Sci Rep. 2016;6:19089 pubmed publisher
Zhan Y, Carrington E, Ko H, Vikstrom I, Oon S, Zhang J, et al. Bcl-2 antagonists kill plasmacytoid dendritic cells from lupus-prone mice and dampen interferon-α production. Arthritis Rheumatol. 2015;67:797-808 pubmed publisher
Park S, Jing X, Gupta D, Dziarski R. Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses. J Immunol. 2013;190:3480-92 pubmed publisher
Dong H, Stanek O, Salvador F, Langer U, Morillon E, Ung C, et al. Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells. Mucosal Immunol. 2013;6:522-34 pubmed publisher
Bachem A, Hartung E, Güttler S, Mora A, Zhou X, Hegemann A, et al. Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation. Front Immunol. 2012;3:214 pubmed publisher
Mizuno S, Kanai T, Mikami Y, Sujino T, Ono Y, Hayashi A, et al. CCR9+ plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice. Immunol Lett. 2012;146:64-9 pubmed publisher
Ritprajak P, Hayakawa M, Sano Y, Otsu K, Park J. Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease. Proc Natl Acad Sci U S A. 2012;109:9089-94 pubmed publisher
Noel G, DeKoter R, Wang Q, Hexley P, Ogle C. Optimization and application of a flow cytometric PU.1 assay for murine immune cells. J Immunol Methods. 2012;382:81-92 pubmed publisher
Benson H, Suzuki H, Lott J, Fisher A, Walline C, Heidler K, et al. Donor lung derived myeloid and plasmacytoid dendritic cells differentially regulate T cell proliferation and cytokine production. Respir Res. 2012;13:25 pubmed publisher
Wainwright D, Balyasnikova I, Han Y, Lesniak M. The expression of BST2 in human and experimental mouse brain tumors. Exp Mol Pathol. 2011;91:440-6 pubmed publisher
Ohue R, Nakamoto M, Kitabatake N, Tani F. Changes in lamina propria dendritic cells on the oral administration of exogenous protein antigens during weaning. Cytotechnology. 2012;64:221-30 pubmed publisher
Guarda G, Zenger M, Yazdi A, Schroder K, Ferrero I, Menu P, et al. Differential expression of NLRP3 among hematopoietic cells. J Immunol. 2011;186:2529-34 pubmed publisher
Shaw P, Barr M, Lukens J, McGargill M, Chi H, Mak T, et al. Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity. Immunity. 2011;34:75-84 pubmed publisher
Cheung D, Ehlenbach S, Kitchens R, Riley D, Thomas L, Holtzman M, et al. Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma. J Immunol. 2010;185:4983-7 pubmed publisher
Freire T, Zhang X, Deriaud E, Ganneau C, Vichier Guerre S, Azria E, et al. Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant. Blood. 2010;116:3526-36 pubmed publisher
Goffinet C, Schmidt S, Kern C, Oberbremer L, Keppler O. Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses. J Virol. 2010;84:11374-84 pubmed publisher
Mishima Y, Ishihara S, Aziz M, Oka A, Kusunoki R, Otani A, et al. Decreased production of interleukin-10 and transforming growth factor-? in Toll-like receptor-activated intestinal B cells in SAMP1/Yit mice. Immunology. 2010;131:473-87 pubmed publisher
Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, et al. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol. 2010;184:6133-41 pubmed publisher
Eidenschenk C, Crozat K, Krebs P, Arens R, Popkin D, Arnold C, et al. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc Natl Acad Sci U S A. 2010;107:9759-64 pubmed publisher
Bar On L, Jung S. Defining in vivo dendritic cell functions using CD11c-DTR transgenic mice. Methods Mol Biol. 2010;595:429-42 pubmed publisher
Chung J, Yudate T, Tomihari M, Akiyoshi H, Cruz P, Ariizumi K. Binding of DC-HIL to dermatophytic fungi induces tyrosine phosphorylation and potentiates antigen presenting cell function. J Immunol. 2009;183:5190-8 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD317 (BST2, PDCA-1) Monoclonal Antibody (eBio927), Functional Grade, eBioscienceâ„¢
Catalog # :
16-3172-85
Quantity :
500 µg
Price :
US 442
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test, Functional assay: Assay-Dependent
Species :
Mouse
Clone :
eBio927
Isotype :
IgG2b, kappa
Storage :
4° C
Description :
BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein that is involved in the development and growth of B-cells. The surface expression of BST2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level), and myeloma cells. Research studies have shown that BST2 also functions as an inhibitor of retrovirus release from human cells whose activity is antagonized by the HIV-1 accessory protein, Vpu. While BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release, an activity that may represent a potential therapeutic strategy for the treatment of HIV/AIDS. Another disease associated with BST2 dysfunction is stomatitis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test, Functional assay: Assay-Dependent
Aliases :
2310015I10Rik; Bone marrow stromal antigen 2; bone marrow stromal cell antigen 2; Bst2; BST-2; C87040; CD317; Damp1; DAMP-1; DAMP-1 protein homolog; GREG; HM1.24 antigen; NPC-A-7; PDCA-1; protein DAMP-1; TETHERIN
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA