CD244 Monoclonal Antibody (eBioPP35 (PP35)), Functional Grade, eBioscience™ | Invitrogen 16-2449-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD244 Monoclonal Antibody (eBioPP35 (PP35)), Functional Grade, eBioscience™

catalog :

16-2449-81

quantity :

50 µg

price :

US 102

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

eBioPP35 (PP35)

reactivity :

human

application :

flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; loading ...; fig 5	Djaoud Z, Guethlein L, Horowitz A, Azzi T, Nemat Gorgani N, Olive D, et al. Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and ?? T cells. J Exp Med. 2017;214:1827-1841 pubmed publisher
	Voss K, Lake C, Luthers C, Lott N, Dorjbal B, Arjunaraja S, et al. FOXP3 protects conventional human T cells from premature restimulation-induced cell death. Cell Mol Immunol. 2019;: pubmed publisher
	Lichtenegger F, Rothe M, Schnorfeil F, Deiser K, Krupka C, Augsberger C, et al. Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells. Front Immunol. 2018;9:385 pubmed publisher
	Cetica V, Sieni E, Pende D, Danesino C, De Fusco C, Locatelli F, et al. Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry. J Allergy Clin Immunol. 2016;137:188-196.e4 pubmed publisher
	Meazza R, Tuberosa C, Cetica V, Falco M, Parolini S, Grieve S, et al. Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis. J Allergy Clin Immunol. 2014;134:1381-1387.e7 pubmed publisher
	Yang B, Wang X, Jiang J, Cheng X. Involvement of CD244 in regulating CD4+ T cell immunity in patients with active tuberculosis. PLoS ONE. 2013;8:e63261 pubmed publisher
	Schlaphoff V, Lunemann S, Suneetha P, Jaroszewicz J, Grabowski J, Dietz J, et al. Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells. PLoS Pathog. 2011;7:e1002045 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD244 Monoclonal Antibody (eBioPP35 (PP35)), Functional Grade, eBioscience™

Catalog # :

16-2449-81

Quantity :

50 µg

Price :

US 102

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay Dependent, Functional assay: Assay-Dependent

Species :

Human

Clone :

eBioPP35 (PP35)

Isotype :

IgG1

Storage :

4° C

Description :

CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay Dependent, Functional assay: Assay-Dependent

Aliases :

2B4; C9.1; Cd244; CD244 long isoform; CD244 molecule; Cd244 molecule, natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4; CD244 short isoform; F730046O15Rik; h2B4; Ly90; NAIL; Natural killer cell receptor 2B4; NK cell activation inducing ligand NAIL; NK cell activation-inducing ligand; NK cell receptor 2B4; NK cell type I receptor protein 2B4; NKR Nmrk; NKR2B4; Nmrk; non MHC restricted killing associated; Non-MHC restricted killing associated; signaling lymphocytic activation molecule 4; SLAM family member 4; SLAMF4; transmembrane NK cell receptor 2B4

more info or order :

Invitrogen product webpage