CD209b (SIGN-R1) Monoclonal Antibody (eBio22D1 (22D1)), Functional Grade, eBioscience | Invitrogen 16-2093-203 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD209b (SIGN-R1) Monoclonal Antibody (eBio22D1 (22D1)), Functional Grade, eBioscience

catalog :

16-2093-203

quantity :

3 mg

price :

US 1994.00

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

eBio22D1 (22D1)

reactivity :

mouse

application :

ELISA, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 4c	Zhang Q, Xiang L, Zaman M, Dong W, He G, Deng G. Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus. Front Immunol. 2019;10:3020 pubmed publisher
	Rani G, Ashwin H, Brown N, Hitchcock I, Kaye P. Hematological consequences of malaria in mice previously treated for visceral leishmaniasis. Wellcome Open Res. 2021;6:83 pubmed publisher
	Kim E, Woodruff M, Grigoryan L, Maier B, Lee S, Mandal P, et al. Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway. elife. 2020;9: pubmed publisher
	Matsuda T, Yanase S, Takaoka A, Maruyama M. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. Immun Ageing. 2015;12:1 pubmed publisher
	Nagaoka K, Takahara K, Tanaka K, Yoshida H, Steinman R, Saitoh S, et al. Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria. Int Immunol. 2005;17:827-36 pubmed
	Kang Y, Kim J, Bruening S, Pack M, Charalambous A, Pritsker A, et al. The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen. Proc Natl Acad Sci U S A. 2004;101:215-20 pubmed

product information

Product Type :

Antibody

Product Name :

CD209b (SIGN-R1) Monoclonal Antibody (eBio22D1 (22D1)), Functional Grade, eBioscience

Catalog # :

16-2093-203

Quantity :

3 mg

Price :

US 1994.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

ELISA: Assay-Dependent, Flow Cytometry: 0.5 ug/test, Functional Assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent

Species :

Mouse

Clone :

eBio22D1 (22D1)

Isotype :

IgG

Storage :

4 C

Description :

SIGNR1 is a type II transmembrane C-type lectin that was identified in a search for mouse homologues of human DC-SIGN. It is expressed at high levels in splenic marginal zone macrophages and lymph node medullary macrophages, where it functions to uptake dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae. It has also been demonstrated that SIGNR1 physically associates with TLR4/MD2, and it has been suggested that this association plays a role in recognition of LPS. Furthermore, recently it has been shown that SIGNR1 deficient mice have a defect in catabolism of the complement component C3, and that SIGNR1 binds directly to the complement C1 subcomponent, C1q to assemble a non-conventional C3 convertase.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Flow Cytometry: 0.5 ug/test, Functional Assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent

Aliases :

1810030I22Rik; CD209; CD209 antigen-like protein A; CD209 antigen-like protein B; Cd209a; CD209a antigen; CD209a molecule; Cd209b; CD209b antigen; CDSIGN; CIRE; DC SIGNR1; Dcsign; DC-SIGN; DC-SIGN1; DC-SIGNR1; DC-SIGN-related protein 1; Dendritic cell-specific ICAM-3-grabbing non-integrin; MGC130443; mSIGNR1; OtB7; SIGNR1; SIGN-R1; SIGNR5

more info or order :

Invitrogen product webpage