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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD197 (CCR7) Monoclonal Antibody (4B12), Functional Grade, eBioscienceâ„¢
catalog :
16-1971-38
quantity :
5 mg
price :
US 2860
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
4B12
reactivity :
mouse
application :
immunoprecipitation, flow cytometry, blocking or activating experiments
more info or order :
Invitrogen product webpage
citations: 38
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; mouse; fig 6a
Hu X, Deng Q, Ma L, Li Q, Chen Y, Liao Y, et al. Meningeal lymphatic vessels regulate brain tumor drainage and immunity. Cell Res. 2020;30:229-243 pubmed publisher
Spath S, Roan F, Presnell S, H xf6 llbacher B, Ziegler S. Profiling of Tregs across tissues reveals plasticity in ST2 expression and hierarchies in tissue-specific phenotypes. iScience. 2022;25:104998 pubmed publisher
Artinger M, Matti C, Gerken O, Veldkamp C, Legler D. A Versatile Toolkit for Semi-Automated Production of Fluorescent Chemokines to Study CCR7 Expression and Functions. Int J Mol Sci. 2021;22: pubmed publisher
Joseph R, Soundararajan R, Vasaikar S, Yang F, Allton K, Tian L, et al. CD8+ T cells inhibit metastasis and CXCL4 regulates its function. Br J Cancer. 2021;125:176-189 pubmed publisher
Lee W, Kingstad Bakke B, Paulson B, Larsen A, Overmyer K, Marinaik C, et al. Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells. PLoS Pathog. 2021;17:e1009168 pubmed publisher
Zhao K, Tian Y, Wang J, Chen C, Pan B, Yan Z, et al. Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2. Biomed Res Int. 2020;2020:7619849 pubmed publisher
Wang Y, Wang Q, Wang B, Gu Y, Yu H, Yang W, et al. Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells. Cell Death Dis. 2020;11:1024 pubmed publisher
Zhu X, Liu H, Zhang Z, Wei R, Zhou X, Wang Z, et al. MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization. Int J Biol Sci. 2020;16:2248-2264 pubmed publisher
Vanderleyden I, Fra Bido S, Innocentin S, Stebegg M, Okkenhaug H, Evans Bailey N, et al. Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5. Cell Rep. 2020;30:611-619.e4 pubmed publisher
Nicosia M, Miyairi S, Beavers A, Farr G, McGuirk P, Pelletier M, et al. Aquaporin 4 inhibition alters chemokine receptor expression and T cell trafficking. Sci Rep. 2019;9:7417 pubmed publisher
Dill Garlow R, Chen K, Walker A. Sex Differences in Mouse Popliteal Lymph Nodes. Sci Rep. 2019;9:965 pubmed publisher
Li X, Dai Y, Shen T, Gao C. Induced migration of endothelial cells into 3D scaffolds by chemoattractants secreted by pro-inflammatory macrophages in situ. Regen Biomater. 2017;4:139-148 pubmed publisher
Lundberg V, Berglund M, Skogberg G, Lindgren S, Lundqvist C, Gudmundsdottir J, et al. Thymic exosomes promote the final maturation of thymocytes. Sci Rep. 2016;6:36479 pubmed publisher
Shu Z, Shu X, Li H, Sun Y, Shan H, Sun X, et al. Ginkgolide B Protects Against Ischemic Stroke Via Modulating Microglia Polarization in Mice. CNS Neurosci Ther. 2016;22:729-39 pubmed publisher
Peske J, Thompson E, Gemta L, Baylis R, Fu Y, Engelhard V. Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. Nat Commun. 2015;6:7114 pubmed publisher
Miyazaki M, Miyazaki K, Chen S, Chandra V, Wagatsuma K, Agata Y, et al. The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis. Genes Dev. 2015;29:409-25 pubmed publisher
Pugh J, Sukhina A, Seed T, Manley N, Sempowski G, van den Brink M, et al. Histone deacetylation critically determines T cell subset radiosensitivity. J Immunol. 2014;193:1451-8 pubmed publisher
Mollo S, Zajac A, Harrington L. Temporal requirements for B cells in the establishment of CD4 T cell memory. J Immunol. 2013;191:6052-9 pubmed publisher
Langenhorst D, Gogishvili T, Ribechini E, Kneitz S, McPherson K, Lutz M, et al. Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells. PLoS ONE. 2012;7:e50080 pubmed publisher
Bunders M, van der Loos C, Klarenbeek P, van Hamme J, Boer K, Wilde J, et al. Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1. Blood. 2012;120:4383-90 pubmed publisher
Wang C, Lee J, Kim C. Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch. PLoS ONE. 2012;7:e30793 pubmed publisher
Nouri Shirazi M, Guinet E. Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination. J Immunol. 2012;188:2359-70 pubmed publisher
Zhao J, Zhao J, LEGGE K, Perlman S. Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest. 2011;121:4921-30 pubmed publisher
Gnade B, Moen S, Chopra A, Peterson J, Yeager L. Emergence of anthrax edema toxin as a master manipulator of macrophage and B cell functions. Toxins (Basel). 2010;2:1881-97 pubmed publisher
Tan X, Sande J, Pufnock J, Blattman J, Greenberg P. Retinoic acid as a vaccine adjuvant enhances CD8+ T cell response and mucosal protection from viral challenge. J Virol. 2011;85:8316-27 pubmed publisher
Tabbekh M, Franciszkiewicz K, Haouas H, Lecluse Y, Benihoud K, Raman C, et al. Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice. J Immunol. 2011;187:102-9 pubmed publisher
Kar U, Srivastava M, Andersson A, Baratelli F, Huang M, Kickhoefer V, et al. Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth. PLoS ONE. 2011;6:e18758 pubmed publisher
Ramachandran I, Song W, Lapteva N, Seethammagari M, Slawin K, Spencer D, et al. The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function. J Immunol. 2011;186:3934-45 pubmed publisher
Muthumani G, Laddy D, Sundaram S, Fagone P, Shedlock D, Kannan S, et al. Co-immunization with an optimized plasmid-encoded immune stimulatory interleukin, high-mobility group box 1 protein, results in enhanced interferon-gamma secretion by antigen-specific CD8 T cells. Immunology. 2009;128:e612-20 pubmed publisher
Himoudi N, Yan M, Bouma G, Morgenstern D, Wallace R, Seddon B, et al. Migratory and antigen presentation functions of IFN-producing killer dendritic cells. Cancer Res. 2009;69:6598-606 pubmed publisher
Liu X, Leerberg J, MacDonald K, Leggatt G, Frazer I. IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host. J Immunol. 2009;183:51-8 pubmed publisher
Tokoyoda K, Zehentmeier S, Hegazy A, Albrecht I, Grün J, Löhning M, et al. Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow. Immunity. 2009;30:721-30 pubmed publisher
Takatori H, Kanno Y, Watford W, Tato C, Weiss G, Ivanov I, et al. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med. 2009;206:35-41 pubmed publisher
MartIn Fontecha A, Baumjohann D, Guarda G, Reboldi A, Hons M, Lanzavecchia A, et al. CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming. J Exp Med. 2008;205:2561-74 pubmed publisher
Villablanca E, Zhou D, Valentinis B, Negro A, Raccosta L, Mauri L, et al. Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo. J Leukoc Biol. 2008;84:871-9 pubmed publisher
Ueha S, Yoneyama H, Hontsu S, Kurachi M, Kitabatake M, Abe J, et al. CCR7 mediates the migration of Foxp3+ regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules. J Leukoc Biol. 2007;82:1230-8 pubmed
Waldner H, Sobel R, Price N, Kuchroo V. The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells. J Immunol. 2006;176:5455-62 pubmed
Bjorkdahl O, Barber K, Brett S, Daly M, Plumpton C, Elshourbagy N, et al. Characterization of CC-chemokine receptor 7 expression on murine T cells in lymphoid tissues. Immunology. 2003;110:170-9 pubmed
product information
Product Type :
Antibody
Product Name :
CD197 (CCR7) Monoclonal Antibody (4B12), Functional Grade, eBioscienceâ„¢
Catalog # :
16-1971-38
Quantity :
5 mg
Price :
US 2860
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Control: Assay-Dependent, Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent
Species :
Mouse
Clone :
4B12
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
CCR7 is a member of the G protein coupled receptor family, which is a subfamily of chemokines. CCR7 was identified to be induced by the Epstein Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine. CCR7 is particularly expressed in lymphoid tissues and in activated B and T lymphocytes and has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries. Receptors for the C - C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.
Format :
Liquid
Applications w/Dilutions :
Control: Assay-Dependent, Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent, Immunoprecipitation: Assay-Dependent
Aliases :
BLR2; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; C-C chemokine receptor type 7; C-C CKR-7; C-C motif chemokine receptor 7; CC-CKR-7; Ccr7; CCR-7; CD197; CDw197; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; Cmkbr7; EBI1; Ebi1h; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA