CD180 (RP105) Monoclonal Antibody (MHR73-11), Functional Grade, eBioscience | Invitrogen 16-1809-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD180 (RP105) Monoclonal Antibody (MHR73-11), Functional Grade, eBioscience

catalog :

16-1809-025

quantity :

25 mg

price :

US 8250

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MHR73-11

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Polson A, Calemine Fenaux J, Chan P, Chang W, Christensen E, Clark S, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res. 2009;69:2358-64 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD180 (RP105) Monoclonal Antibody (MHR73-11), Functional Grade, eBioscience

Catalog # :

16-1809-025

Quantity :

25 mg

Price :

US 8250

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent

Species :

Human

Clone :

MHR73-11

Isotype :

IgG1, kappa

Storage :

4° C

Description :

CD180 (RP105, Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. CD180 cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1, and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size. CD180 consists of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is part of the cell surface receptor complex, RP105/MD-1. Diseases associated with CD180 dysfunction include Kawasaki Disease in children and may play a role in rheumatic disease pathology.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent

Aliases :

CD180; CD180 antigen; CD180 molecule; F630107B15; LY64; Ly78; Ly-78; lymphocyte antigen 64; Lymphocyte antigen 78; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; radioprotective 105 kDa protein; RP105