CD152 (CTLA-4) Monoclonal Antibody (9H10), Functional Grade, eBioscience™ | Invitrogen 16-1521-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD152 (CTLA-4) Monoclonal Antibody (9H10), Functional Grade, eBioscience™

catalog :

16-1521-025

quantity :

25 mg

price :

US 7500.00

clonality :

monoclonal

host :

Syrian golden hamster

conjugate :

nonconjugated

clone name :

9H10

reactivity :

mouse

application :

flow cytometry

citations: 9

Reference
Zhang B, Dang J, Ba D, Wang C, Han J, Zheng F. Potential function of CTLA-4 in the tumourigenic capacity of melanoma stem cells. Oncol Lett. 2018;16:6163-6170 pubmed publisher
Bagchi S, Li S, Wang C. CD1b-autoreactive T cells recognize phospholipid antigens and contribute to antitumor immunity against a CD1b+ T cell lymphoma. Oncoimmunology. 2016;5:e1213932 pubmed
Bodhankar S, Chen Y, Lapato A, Vandenbark A, Murphy S, Offner H. Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke. Front Cell Neurosci. 2014;8:228 pubmed publisher
Engeland C, Grossardt C, Veinalde R, Bossow S, Lutz D, Kaufmann J, et al. CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy. Mol Ther. 2014;22:1949-59 pubmed publisher
Verhagen J, Wraith D. Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3? Treg cells. J Immunol Methods. 2014;414:58-64 pubmed publisher
Yoshimoto Y, Suzuki Y, Mimura K, Ando K, Oike T, Sato H, et al. Radiotherapy-induced anti-tumor immunity contributes to the therapeutic efficacy of irradiation and can be augmented by CTLA-4 blockade in a mouse model. PLoS ONE. 2014;9:e92572 pubmed publisher
Iannone R, Miele L, Maiolino P, Pinto A, Morello S. Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model. Am J Cancer Res. 2014;4:172-81 pubmed
Wu L, Yun Z, Tagawa T, Rey McIntyre K, de Perrot M. CTLA-4 blockade expands infiltrating T cells and inhibits cancer cell repopulation during the intervals of chemotherapy in murine mesothelioma. Mol Cancer Ther. 2012;11:1809-19 pubmed publisher
Mellor A, Chandler P, Baban B, Hansen A, Marshall B, Pihkala J, et al. Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase. Int Immunol. 2004;16:1391-401 pubmed

product information

Product Type :

Antibody

Product Name :

CD152 (CTLA-4) Monoclonal Antibody (9H10), Functional Grade, eBioscience™

Catalog # :

16-1521-025

Quantity :

25 mg

Price :

US 7500.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Syrian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent

Species :

Mouse

Clone :

9H10

Isotype :

IgG

Storage :

4° C

Description :

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent

Aliases :

ALPS5; CD; CD152; CD152 antigen; CD152 isoform; CD152 protein; CD152 protein precursor; celiac disease 3; CELIAC3; Ctla4; CTLA-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte associated protein 4; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; EGK_04712; GRD4; GSE; ICOS; IDDM12; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; Ly-56; sCTLA4; soluble form; transmembrane form