CD120a (TNF Receptor I) Monoclonal Antibody (55R-170), Functional Grade, eBioscience™ | Invitrogen 16-1202-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD120a (TNF Receptor I) Monoclonal Antibody (55R-170), Functional Grade, eBioscience™

catalog :

16-1202-025

quantity :

25 mg

price :

US 7500.00

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

55R-170

reactivity :

mouse

application :

neutralization

citations: 4

Reference
Chuang T, Cheng A, Chen I, Lan T, Huang I, Shiau C, et al. Suppression of LPS-induced inflammatory responses by the hydroxyl groups of dexamethasone. Oncotarget. 2017;8:49735-49748 pubmed publisher
Shivakumar P, Mizuochi T, Mourya R, Gutta S, Yang L, Luo Z, et al. Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia. JCI Insight. 2017;2:e88747 pubmed publisher
Vuong B, Hogan Cann A, Alano C, Stevenson M, Chan W, Anderson C, et al. NF-ÎºB transcriptional activation by TNFÎ± requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1. J Neuroinflammation. 2015;12:229 pubmed publisher
Klinke D, Cheng N, Chambers E. Quantifying crosstalk among interferon-?, interleukin-12, and tumor necrosis factor signaling pathways within a TH1 cell model. Sci Signal. 2012;5:ra32 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD120a (TNF Receptor I) Monoclonal Antibody (55R-170), Functional Grade, eBioscience™

Catalog # :

16-1202-025

Quantity :

25 mg

Price :

US 7500.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Functional assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Mouse

Clone :

55R-170

Isotype :

IgG

Storage :

4° C

Description :

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.

Format :

Liquid

Applications w/Dilutions :

Functional assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

CD120a; CD120a antigen; FPF; hypothetical protein; LOC100346106; MGC19588; MS5; n-smase activation assoc. factor; p55; p55 TNF receptor; p55-R; p60; p62; p63; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TBP1; TBPI; TNF receptor alpha chain; TNF receptor superfamily member 1A; TNF-alphaR1; TNF-alpha-R1; TNFalpha-R1; TNFAR; TNFR; TNF-R; TNFR I; TNFR1; TNF-R1; Tnfr-1; TNFR1-d2; Tnfr-2; TNFR55; TNF-R55; TNFR60; TNFRI; TNF-RI; TNF-R-I; TNFR-I; TNFRp55; TNFRSF1A; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor; tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor 1-like; tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor superfamily member 1A, membrane form; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor; Tumor necrosis factor-binding protein 1