CD117 (c-Kit) Monoclonal Antibody (ACK2), Functional Grade, eBioscience | Invitrogen 16-1172-050 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD117 (c-Kit) Monoclonal Antibody (ACK2), Functional Grade, eBioscience

catalog :

16-1172-050

quantity :

50 mg

price :

US 13750

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

ACK2

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 27

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...	Ricci B, Tycksen E, Celik H, Belle J, Fontana F, Civitelli R, et al. Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics. elife. 2020;9: pubmed publisher
	Gentle I, Moelter I, Badr M, D xf6 hner K, L xfc bbert M, H xe4 cker G. The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression. Cell Death Dis. 2021;12:675 pubmed publisher
	Abd Elhafeez H, Abdo W, Kamal B, Soliman S. Fish telocytes and their relation to rodlet cells in ruby-red-fin shark (rainbow shark) Epalzeorhynchos frenatum (Teleostei: Cyprinidae). Sci Rep. 2020;10:18907 pubmed publisher
	Naka K, Ochiai R, Matsubara E, Kondo C, Yang K, Hoshii T, et al. The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2020;11:4681 pubmed publisher
	Abd Elhafeez H, Abou Elhamd A, Soliman S. Morphological and immunohistochemical phenotype of TCs in the intestinal bulb of Grass carp and their potential role in intestinal immunity. Sci Rep. 2020;10:14039 pubmed publisher
	Boichuk S, Galembikova A, Mikheeva E, Bikinieva F, Aukhadieva A, Dunaev P, et al. Inhibition of FGF2-Mediated Signaling in GIST-Promising Approach for Overcoming Resistance to Imatinib. Cancers (Basel). 2020;12: pubmed publisher
	Kwak M, Ninche N, Klein S, Saur D, Ghazizadeh S. c-Kit+ Cells in Adult Salivary Glands do not Function as Tissue Stem Cells. Sci Rep. 2018;8:14193 pubmed publisher
	Kobayashi M, Khalil H, Lei N, Wang Q, Wang K, Wu B, et al. Bioengineering functional smooth muscle with spontaneous rhythmic contraction in vitro. Sci Rep. 2018;8:13544 pubmed publisher
	Zhao J, An J, Liu S. Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1/CXCR4 and mSCF/Kit-ETV1 Pathways in the Stomach of Diabetic Mice. Evid Based Complement Alternat Med. 2018;2018:7878053 pubmed publisher
	Zhang C, Wang M, He N, Ahmed M, Wang Y, Zhao R, et al. Hsd3b2 associated in modulating steroid hormone synthesis pathway regulates the differentiation of chicken embryonic stem cells into spermatogonial stem cells. J Cell Biochem. 2018;119:1111-1121 pubmed publisher
	Géraud C, Koch P, Zierow J, Klapproth K, Busch K, Olsavszky V, et al. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017;127:1099-1114 pubmed publisher
	Shirai C, White B, Tripathi M, Tapia R, Ley J, Ndonwi M, et al. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nat Commun. 2017;8:14060 pubmed publisher
	Astuti Y, Kramer A, Blake A, Blazar B, Tolar J, Taisto M, et al. A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing. Stem Cell Reports. 2017;8:177-190 pubmed publisher
	Malysz J, Gibbons S, Saravanaperumal S, Du P, Eisenman S, Cao C, et al. Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca2+ transients and slow waves in adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2017;312:G228-G245 pubmed publisher
	Zhou Y, Copeland B, Otto Duessel M, He M, Markel S, Synold T, et al. Low Testosterone Alters the Activity of Mouse Prostate Stem Cells. Prostate. 2017;77:530-541 pubmed publisher
	Lai M, Gonzalez Martin A, Cooper A, Oda H, Jin H, Shepherd J, et al. Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs. Nat Commun. 2016;7:12207 pubmed publisher
	Puram R, Kowalczyk M, de Boer C, Schneider R, Miller P, McConkey M, et al. Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML. Cell. 2016;165:303-16 pubmed publisher
	Zhu Y, Wang X, Parsons S, Huizinga J. Stimulus-induced pacemaker activity in interstitial cells of Cajal associated with the deep muscular plexus of the small intestine. Neurogastroenterol Motil. 2016;28:1064-74 pubmed publisher
	Young K, Torres E, Hehre D, Wu S, Suguihara C, Hare J. Antagonism of stem cell factor/c-kit signaling attenuates neonatal chronic hypoxia-induced pulmonary vascular remodeling. Pediatr Res. 2016;79:637-46 pubmed publisher
	Visekruna A, Linnerz T, Martinic V, Vachharajani N, Hartmann S, Harb H, et al. Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis. Mucosal Immunol. 2015;8:307-15 pubmed publisher
	Huizinga J, Chen J, Zhu Y, Pawelka A, McGinn R, Bardakjian B, et al. The origin of segmentation motor activity in the intestine. Nat Commun. 2014;5:3326 pubmed publisher
	Oh M, Oh S, Lu J, Lou H, Myers A, Zhu Z, et al. TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis. J Immunol. 2013;191:5371-82 pubmed publisher
	Schjerven H, McLaughlin J, Arenzana T, Frietze S, Cheng D, Wadsworth S, et al. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013;14:1073-83 pubmed publisher
	Carmona R, Cano E, Mattiotti A, Gaztambide J, Muñoz Chápuli R. Cells derived from the coelomic epithelium contribute to multiple gastrointestinal tissues in mouse embryos. PLoS ONE. 2013;8:e55890 pubmed publisher
	Smith D, Tan X, Raveendran V, Tawfik O, Stechschulte D, Dileepan K. Mast cell deficiency attenuates progression of atherosclerosis and hepatic steatosis in apolipoprotein E-null mice. Am J Physiol Heart Circ Physiol. 2012;302:H2612-21 pubmed publisher
	Vitsky A, Waire J, Pawliuk R, Bond A, Matthews D, Lacasse E, et al. Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues. Am J Pathol. 2009;174:2137-49 pubmed publisher
	Czechowicz A, Kraft D, Weissman I, Bhattacharya D. Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science. 2007;318:1296-9 pubmed

product information

Product Type :

Antibody

Product Name :

CD117 (c-Kit) Monoclonal Antibody (ACK2), Functional Grade, eBioscience

Catalog # :

16-1172-050

Quantity :

50 mg

Price :

US 13750

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.125 µg/test, Functional Assay: Assay-Dependent

Species :

Mouse

Clone :

ACK2

Isotype :

IgG2b, kappa

Storage :

4° C

Description :

c-Kit, also known as mast/stem cell growth factor receptor (SCFR) or CD117, is a trans membrane type III tyrosine kinase receptor encoded by the c-Kit proto-oncogene, located on chromosome 4 in humans. It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 µg/test, Functional Assay: Assay-Dependent

Aliases :

belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W

more info or order :

Invitrogen product webpage