CD95 (APO-1/Fas) Monoclonal Antibody (EOS9.1), Functional Grade, eBioscience | Invitrogen 16-0958-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD95 (APO-1/Fas) Monoclonal Antibody (EOS9.1), Functional Grade, eBioscience

catalog :

16-0958-81

quantity :

50 µg

price :

US 120

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

EOS9.1

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 5	Rapetti L, Chavele K, Evans C, Ehrenstein M. B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis. Ann Rheum Dis. 2015;74:294-302 pubmed publisher
	Fairén A, Parro V, Schulze Makuch D, Whyte L. Is Searching for Martian Life a Priority for the Mars Community?. Astrobiology. 2018;18:101-107 pubmed publisher
	Mou H, Moore J, Malonia S, Li Y, Ozata D, Hough S, et al. Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Proc Natl Acad Sci U S A. 2017;114:3648-3653 pubmed publisher
	Rong G, Zhong R, Lleo A, Leung P, Bowlus C, Yang G, et al. Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis. Hepatology. 2011;54:196-203 pubmed publisher
	Schnyder S, Du N, Le H, Singh S, Loredo G, Vaughan A. Estrogen treatment induces MLL aberrations in human lymphoblastoid cells. Leuk Res. 2009;33:1400-4 pubmed publisher
	Kamegaya Y, Hiasa Y, Zukerberg L, Fowler N, Blackard J, Lin W, et al. Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis. Hepatology. 2005;41:660-7 pubmed

product information

Product Type :

Antibody

Product Name :

CD95 (APO-1/Fas) Monoclonal Antibody (EOS9.1), Functional Grade, eBioscience

Catalog # :

16-0958-81

Quantity :

50 µg

Price :

US 120

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent

Species :

Human

Clone :

EOS9.1

Isotype :

IgM, kappa

Storage :

4° C

Description :

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent

Aliases :

AI196731; ALPS1A; APO1; APO-1; Apo1 antigen; Apo-1 antigen; APO-1 cell surface antigen; Apo-1 Fas; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; FAS; Fas (TNF receptor superfamily member 6); Fas (TNF receptor superfamily member); Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; Fas antigen (ATP1); Fas cell surface death receptor; Fas receptor; FAS1; FASLG receptor; FASTM; lpr; lymphoproliferation; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; TNF receptor superfamily member 6; TNFR6; Tnfrsf6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 26; Tumor necrosis factor receptor superfamily, member 6

more info or order :

Invitrogen product webpage