product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD69 Monoclonal Antibody (H1.2F3), Functional Grade, eBioscience™
catalog :
16-0691-85
quantity :
500µg
price :
US 310
clonality :
monoclonal
host :
hamsters
conjugate :
nonconjugated
clone name :
H1.2F3
reactivity :
human, mouse
application :
flow cytometry
more info or order :
citations: 124
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 1e
Visekruna A, Hartmann S, Sillke Y, Glauben R, Fischer F, Raifer H, et al. Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells. J Clin Invest. 2019;129:1972-1983 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3f
McLaren J, Clement M, Marsden M, Miners K, Llewellyn Lacey S, Grant E, et al. IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine. J Immunol. 2019;202:943-955 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4e
Bern M, Parikh B, Yang L, Beckman D, Poursine Laurent J, Yokoyama W. Inducible down-regulation of MHC class I results in natural killer cell tolerance. J Exp Med. 2019;216:99-116 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1d
Xing S, Shao P, Li F, Zhao X, Seo W, Wheat J, et al. Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity. J Exp Med. 2018;215:2211-2226 pubmed publisher
  • flow cytometry; mouse; 1:6; fig s2c
Gu C, Borjabad A, Hadas E, Kelschenbach J, Kim B, Chao W, et al. EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment. PLoS Pathog. 2018;14:e1007061 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3
Safya H, Mellouk A, Legrand J, Le Gall S, Benbijja M, Kanellopoulos Langevin C, et al. Variations in Cellular Responses of Mouse T Cells to Adenosine-5'-Triphosphate Stimulation Do Not Depend on P2X7 Receptor Expression Levels but on Their Activation and Differentiation Stage. Front Immunol. 2018;9:360 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Cortes J, Ambesi Impiombato A, Couronné L, Quinn S, Kim C, da Silva Almeida A, et al. RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis. Cancer Cell. 2018;33:259-273.e7 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1d
Turner D, Goldklang M, Cvetkovski F, Paik D, Trischler J, Barahona J, et al. Biased Generation and In Situ Activation of Lung Tissue-Resident Memory CD4 T Cells in the Pathogenesis of Allergic Asthma. J Immunol. 2018;200:1561-1569 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5c
Cowan J, Baik S, McCarthy N, Parnell S, White A, Jenkinson W, et al. Aire controls the recirculation of murine Foxp3+ regulatory T-cells back to the thymus. Eur J Immunol. 2018;48:844-854 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3
Torcellan T, Hampton H, Bailey J, Tomura M, Brink R, Chtanova T. In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors. Proc Natl Acad Sci U S A. 2017;114:5677-5682 pubmed publisher
  • flow cytometry; mouse; fig 4
Goetz B, An W, Mohapatra B, Zutshi N, Iseka F, Storck M, et al. A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells. Oncotarget. 2016;7:51107-51123 pubmed publisher
  • flow cytometry; mouse; fig 1a
Mkhikian H, Mortales C, Zhou R, Khachikyan K, Wu G, Haslam S, et al. Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis. elife. 2016;5: pubmed publisher
  • flow cytometry; mouse; fig 2
Kabat A, Harrison O, Riffelmacher T, Moghaddam A, Pearson C, Laing A, et al. The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. elife. 2016;5:e12444 pubmed publisher
  • flow cytometry; mouse; fig 3
Luo C, Liao W, Dadi S, Toure A, Li M. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016;529:532-6 pubmed publisher
  • flow cytometry; mouse
Xin L, Jiang T, Kinder J, Ertelt J, Way S. Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna(Dhe) mice. Aging Cell. 2015;14:1122-6 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2
Littwitz Salomon E, Akhmetzyanova I, Vallet C, Francois S, Dittmer U, Gibbert K. Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection. Retrovirology. 2015;12:66 pubmed publisher
  • flow cytometry; mouse; 1:500; fig 4
Rouhani S, Eccles J, Riccardi P, Peske J, Tewalt E, Cohen J, et al. Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction. Nat Commun. 2015;6:6771 pubmed publisher
  • flow cytometry; mouse; fig s7
Wensveen F, Jelenčić V, Valentić S, Šestan M, Wensveen T, Theurich S, et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015;16:376-85 pubmed publisher
  • flow cytometry; mouse; tbl s3
Pannu J, Belle J, Forster M, Duerr C, Shen S, Kane L, et al. Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation. PLoS ONE. 2015;10:e0117304 pubmed publisher
  • flow cytometry; mouse; fig 6
Stack G, Jones E, Marsden M, Stacey M, Snelgrove R, Lacaze P, et al. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathog. 2015;11:e1004641 pubmed publisher
  • flow cytometry; mouse; fig 5
Shrestha S, Yang K, Guy C, Vogel P, Neale G, Chi H. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat Immunol. 2015;16:178-87 pubmed publisher
  • flow cytometry; mouse; fig 5
Hartung E, Becker M, Bachem A, Reeg N, Jäkel A, Hutloff A, et al. Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1. J Immunol. 2015;194:1069-79 pubmed publisher
  • flow cytometry; mouse
Yin Y, Qin T, Wang X, Lin J, Yu Q, Yang Q. CpG DNA assists the whole inactivated H9N2 influenza virus in crossing the intestinal epithelial barriers via transepithelial uptake of dendritic cell dendrites. Mucosal Immunol. 2015;8:799-814 pubmed publisher
  • flow cytometry; mouse; fig 4
Guo X, Tanaka Y, Kondo M. Thymic precursors of TCRαβ(+)CD8αα(+) intraepithelial lymphocytes are negative for CD103. Immunol Lett. 2015;163:40-8 pubmed publisher
  • flow cytometry; mouse; fig 1
Mehta P, Nuotio Antar A, Smith C. γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice. J Leukoc Biol. 2015;97:121-34 pubmed publisher
  • flow cytometry; mouse
McDonnell A, Lesterhuis W, Khong A, Nowak A, Lake R, Currie A, et al. Tumor-infiltrating dendritic cells exhibit defective cross-presentation of tumor antigens, but is reversed by chemotherapy. Eur J Immunol. 2015;45:49-59 pubmed publisher
  • flow cytometry; human
Zhu Y, Knolhoff B, Meyer M, Nywening T, West B, Luo J, et al. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res. 2014;74:5057-69 pubmed publisher
  • flow cytometry; mouse; fig 5
Au Yeung B, Melichar H, Ross J, Cheng D, Zikherman J, Shokat K, et al. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nat Immunol. 2014;15:687-94 pubmed publisher
  • flow cytometry; mouse
Geem D, Medina Contreras O, McBride M, Newberry R, Koni P, Denning T. Specific microbiota-induced intestinal Th17 differentiation requires MHC class II but not GALT and mesenteric lymph nodes. J Immunol. 2014;193:431-8 pubmed publisher
  • flow cytometry; mouse; 1:100
Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, et al. Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun. 2014;5:3436 pubmed publisher
  • flow cytometry; mouse
Joedicke J, Dietze K, Zelinskyy G, Dittmer U. The phenotype and activation status of regulatory T cells during Friend retrovirus infection. Virol Sin. 2014;29:48-60 pubmed publisher
  • flow cytometry; mouse
Salem H, Trojanowski B, Fiedler K, Maier H, Schirmbeck R, Wagner M, et al. Long-term IKK2/NF-?B signaling in pancreatic ?-cells induces immune-mediated diabetes. Diabetes. 2014;63:960-75 pubmed publisher
  • flow cytometry; mouse
Gujar S, Clements D, Dielschneider R, Helson E, Marcato P, Lee P. Gemcitabine enhances the efficacy of reovirus-based oncotherapy through anti-tumour immunological mechanisms. Br J Cancer. 2014;110:83-93 pubmed publisher
  • flow cytometry; mouse
Fu G, Casas J, Rigaud S, Rybakin V, Lambolez F, Brzostek J, et al. Themis sets the signal threshold for positive and negative selection in T-cell development. Nature. 2013;504:441-5 pubmed publisher
  • flow cytometry; mouse
Mathew R, Seiler M, Scanlon S, Mao A, Constantinides M, Bertozzi Villa C, et al. BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Nature. 2012;491:618-21 pubmed publisher
  • flow cytometry; mouse
Barral P, Sanchez Nino M, Van Rooijen N, Cerundolo V, Batista F. The location of splenic NKT cells favours their rapid activation by blood-borne antigen. EMBO J. 2012;31:2378-90 pubmed publisher
  • flow cytometry; mouse
Wollenberg I, Agua Doce A, Hernandez A, Almeida C, Oliveira V, Faro J, et al. Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells. J Immunol. 2011;187:4553-60 pubmed publisher
  • flow cytometry; mouse; fig 6, 7
Gibbert K, Dietze K, Zelinskyy G, Lang K, Barchet W, Kirschning C, et al. Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease. J Immunol. 2010;185:6179-89 pubmed publisher
  • flow cytometry; mouse
Park S, Han Y, Aleyas A, George J, Yoon H, Lee J, et al. Low-dose antigen-experienced CD4+ T cells display reduced clonal expansion but facilitate an effective memory pool in response to secondary exposure. Immunology. 2008;123:426-37 pubmed
  • flow cytometry; mouse; tbl 1
Bliss S, Bliss S, Beiting D, Alcaraz A, Appleton J. IL-10 regulates movement of intestinally derived CD4+ T cells to the liver. J Immunol. 2007;178:7974-83 pubmed
  • flow cytometry; mouse
Hamdy S, Elamanchili P, Alshamsan A, Molavi O, Satou T, Samuel J. Enhanced antigen-specific primary CD4+ and CD8+ responses by codelivery of ovalbumin and toll-like receptor ligand monophosphoryl lipid A in poly(D,L-lactic-co-glycolic acid) nanoparticles. J Biomed Mater Res A. 2007;81:652-62 pubmed
  • flow cytometry; mouse
Hale J, Boursalian T, Turk G, Fink P. Thymic output in aged mice. Proc Natl Acad Sci U S A. 2006;103:8447-52 pubmed
  • flow cytometry; mouse
Vanasek T, Nandiwada S, Jenkins M, Mueller D. CD25+Foxp3+ regulatory T cells facilitate CD4+ T cell clonal anergy induction during the recovery from lymphopenia. J Immunol. 2006;176:5880-9 pubmed
  • flow cytometry; mouse; fig 4
Krieg C, Han P, Stone R, Goularte O, Kaye J. Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells. J Immunol. 2005;175:6420-7 pubmed
Fontela M, Notario L, Alari Pahissa E, Lorente E, Lauzurica P. The Conserved Non-Coding Sequence 2 (CNS2) Enhances CD69 Transcription through Cooperation between the Transcription Factors Oct1 and RUNX1. Genes (Basel). 2019;10: pubmed publisher
Vacchio M, Ciucci T, Gao Y, Watanabe M, Balmaceno Criss M, McGinty M, et al. A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation. Immunity. 2019;51:465-478.e6 pubmed publisher
Ronkina N, Schuster Gossler K, Hansmann F, Kunze Schumacher H, Sandrock I, Yakovleva T, et al. Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3. Mol Cell Biol. 2019;39: pubmed publisher
Eldi P, Chaudhri G, Nutt S, Newsome T, Karupiah G. Viral Replicative Capacity, Antigen Availability via Hematogenous Spread, and High TFH:TFR Ratios Drive Induction of Potent Neutralizing Antibody Responses. J Virol. 2019;93: pubmed publisher
Lauron E, Yang L, Harvey I, Sojka D, Williams G, Paley M, et al. Viral MHCI inhibition evades tissue-resident memory T cell formation and responses. J Exp Med. 2019;216:117-132 pubmed publisher
Goehrig D, Nigri J, Samain R, Wu Z, Cappello P, Gabiane G, et al. Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer. Gut. 2019;68:693-707 pubmed publisher
Li F, Zeng Z, Xing S, Gullicksrud J, Shan Q, Choi J, et al. Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun. 2018;9:5452 pubmed publisher
Kunze Schumacher H, Winter S, Imelmann E, Krueger A. miRNA miR-21 Is Largely Dispensable for Intrathymic T-Cell Development. Front Immunol. 2018;9:2497 pubmed publisher
Chinta K, Rahman M, Saini V, Glasgow J, Reddy V, Lever J, et al. Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis. Cell Rep. 2018;25:1938-1952.e5 pubmed publisher
Shi H, Liu C, Tan H, Li Y, Nguyen T, Dhungana Y, et al. Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity. Immunity. 2018;49:899-914.e6 pubmed publisher
Yu X, Lao Y, Teng X, Li S, Zhou Y, Wang F, et al. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nat Commun. 2018;9:3157 pubmed publisher
Gee M, Sibener L, Birnbaum M, Jude K, Yang X, Fernandes R, et al. Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro. Proc Natl Acad Sci U S A. 2018;115:E7369-E7378 pubmed publisher
Hickman H, Mays J, Gibbs J, Kosik I, Magadán J, Takeda K, et al. Influenza A Virus Negative Strand RNA Is Translated for CD8+ T Cell Immunosurveillance. J Immunol. 2018;201:1222-1228 pubmed publisher
Chen E, Brzostek J, Gascoigne N, Rybakin V. Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation. Sci Rep. 2018;8:10046 pubmed publisher
Yang M, Li C, Zhu S, Cao L, Kroemer G, Zeh H, et al. TFAM is a novel mediator of immunogenic cancer cell death. Oncoimmunology. 2018;7:e1431086 pubmed publisher
Weng T, Wu H, Li C, Hung Y, Chang Y, Chen Y, et al. Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation. Sci Rep. 2018;8:8216 pubmed publisher
Quaranta V, Rainer C, Nielsen S, Raymant M, Ahmed M, Engle D, et al. Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. Cancer Res. 2018;78:4253-4269 pubmed publisher
Seydoux E, Liang H, Dubois Cauwelaert N, Archer M, Rintala N, Kramer R, et al. Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses. J Immunol. 2018;201:98-112 pubmed publisher
Greaves S, Peterson J, Torres R, Pelanda R. Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance. Front Immunol. 2018;9:707 pubmed publisher
Lee J, Kim J, Yi J, Kim D, Kim H, Han D, et al. Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells. Front Immunol. 2018;9:437 pubmed publisher
Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G, et al. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun. 2018;9:1241 pubmed publisher
Duggal N, Pollock R, Lazarus N, Harridge S, Lord J. Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood. Aging Cell. 2018;17: pubmed publisher
Jung J, Eggleton P, Robinson A, Wang J, Gutowski N, Holley J, et al. Calnexin is necessary for T cell transmigration into the central nervous system. JCI Insight. 2018;3: pubmed publisher
Blass E, Aid M, Martinot A, Larocca R, Kang Z, Badamchi Zadeh A, et al. Adenovirus Vector Vaccination Impacts NK Cell Rheostat Function following Lymphocytic Choriomeningitis Virus Infection. J Virol. 2018;92: pubmed publisher
Brizic I, Šušak B, Arapovic M, Huszthy P, Hiršl L, Kveštak D, et al. Brain-resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation. Eur J Immunol. 2018;48:950-964 pubmed publisher
Sengar P, Juarez P, Verdugo Meza A, Arellano D, Jain A, Chauhan K, et al. Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy. J Nanobiotechnology. 2018;16:19 pubmed publisher
Liang W, Mao S, Sun S, Li M, Li Z, Yu R, et al. Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation. Front Immunol. 2018;9:78 pubmed publisher
Siracusa F, McGrath M, Maschmeyer P, Bardua M, Lehmann K, Heinz G, et al. Nonfollicular reactivation of bone marrow resident memory CD4 T cells in immune clusters of the bone marrow. Proc Natl Acad Sci U S A. 2018;115:1334-1339 pubmed publisher
Delong J, Hall A, Konradt C, Coppock G, Park J, Harms Pritchard G, et al. Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1. J Immunol. 2018;200:1761-1770 pubmed publisher
Choi J, Pease D, Chen S, Zhang B, Phee H. P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells. Immunology. 2018;154:309-321 pubmed publisher
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, et al. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018;172:517-533.e20 pubmed publisher
Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, et al. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. Nat Cell Biol. 2018;20:21-27 pubmed publisher
Ibrahim M, Scozzi D, Toth K, Ponti D, Kreisel D, Menna C, et al. Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion. J Immunol. 2018;200:847-856 pubmed publisher
Kwak J, Laskowski J, Li H, McSharry M, Sippel T, Bullock B, et al. Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018;78:143-156 pubmed publisher
Milner J, Toma C, Yu B, Zhang K, Omilusik K, Phan A, et al. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours. Nature. 2017;552:253-257 pubmed publisher
Ellen B, Maya I, Tania M, Jessica V, Nele B, Louis B, et al. Lymphocyte-independent pathways underlie the pathogenesis of murine cytomegalovirus-associated secondary hemophagocytic lymphohistiocytosis. Clin Exp Immunol. 2017;: pubmed publisher
Taghavie Moghadam P, Waseem T, Hattler J, Glenn L, Dobrian A, Kaplan M, et al. STAT4 Regulates the CD8+ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr-/- Mice. J Immunol. 2017;199:3453-3465 pubmed publisher
Wang Q, Ning H, Peng H, Wei L, Hou R, Hoft D, et al. Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses. Nat Commun. 2017;8:867 pubmed publisher
Kim Y, Kumar A, Chang C, Pyaram K. Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger. J Immunol. 2017;199:3478-3487 pubmed publisher
Chu F, Hu Y, Zhou Y, Guo M, Lu J, Zheng W, et al. MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway. Clin Exp Immunol. 2017;: pubmed publisher
Delpoux A, Lai C, Hedrick S, Doedens A. FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity. Proc Natl Acad Sci U S A. 2017;114:E8865-E8874 pubmed publisher
White A, Baik S, Parnell S, Holland A, Brombacher F, Jenkinson W, et al. A type 2 cytokine axis for thymus emigration. J Exp Med. 2017;214:2205-2216 pubmed publisher
de Wolf A, van Aalst S, Ludwig I, Bodinham C, Lewis D, van der Zee R, et al. Regulatory T cell frequencies and phenotypes following anti-viral vaccination. PLoS ONE. 2017;12:e0179942 pubmed publisher
Miao T, Symonds A, Singh R, Symonds J, Ogbe A, Omodho B, et al. Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation. J Exp Med. 2017;214:1787-1808 pubmed publisher
Meinicke H, Bremser A, Brack M, Akeus P, Pearson C, Bullers S, et al. Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Immunology. 2017;152:74-88 pubmed publisher
Lehmann C, Baranska A, Heidkamp G, Heger L, Neubert K, Lühr J, et al. DC subset-specific induction of T cell responses upon antigen uptake via Fc? receptors in vivo. J Exp Med. 2017;214:1509-1528 pubmed publisher
González Pérez G, Lamousé Smith E. Gastrointestinal Microbiome Dysbiosis in Infant Mice Alters Peripheral CD8+ T Cell Receptor Signaling. Front Immunol. 2017;8:265 pubmed publisher
Kapnick S, Stinchcombe J, Griffiths G, Schwartzberg P. Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs. J Immunol. 2017;198:2699-2711 pubmed publisher
Ying W, Wollam J, Ofrecio J, Bandyopadhyay G, El Ouarrat D, Lee Y, et al. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest. 2017;127:1019-1030 pubmed publisher
Pohar J, Yamamoto C, Fukui R, Cajnko M, Miyake K, Jerala R, et al. Selectivity of Human TLR9 for Double CpG Motifs and Implications for the Recognition of Genomic DNA. J Immunol. 2017;198:2093-2104 pubmed publisher
Lee P, Zhu Z, Hachmann J, Nojima T, Kitamura D, Salvesen G, et al. Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation. J Immunol. 2017;198:1066-1080 pubmed publisher
Vaidyanathan B, Chaudhry A, Yewdell W, Angeletti D, Yen W, Wheatley A, et al. The aryl hydrocarbon receptor controls cell-fate decisions in B cells. J Exp Med. 2017;214:197-208 pubmed publisher
Zhou Y, Weng X, Dou R, Tan X, Zhang T, Fang J, et al. Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice. Acta Pharmacol Sin. 2017;38:201-210 pubmed publisher
Muschaweckh A, Buchholz V, Fellenzer A, Hessel C, König P, Tao S, et al. Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells. J Exp Med. 2016;213:3075-3086 pubmed
Zamora Pineda J, Kumar A, Suh J, Zhang M, Saba J. Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. J Exp Med. 2016;213:2773-2791 pubmed
Zhao J, Chen C, Guo M, Tao Y, Cui P, Zhou Y, et al. MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4. Front Immunol. 2016;7:389 pubmed
Drennan M, Govindarajan S, Verheugen E, Coquet J, Staal J, McGuire C, et al. NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20. J Exp Med. 2016;213:1973-81 pubmed publisher
Allison K, Sajti E, Collier J, Gosselin D, Troutman T, Stone E, et al. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. elife. 2016;5: pubmed publisher
Menendez C, Jinkins J, Carr D. Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency. J Immunol. 2016;197:1262-75 pubmed publisher
Tan Y, Alkhamees B, Jia D, Li L, Couture J, Figeys D, et al. MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation. Stem Cell Reports. 2015;5:741-52 pubmed publisher
Ying W, Tseng A, Chang R, Morin A, Brehm T, Triff K, et al. MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation. J Clin Invest. 2015;125:4149-59 pubmed publisher
Vogel A, Brown D. Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells. Front Immunol. 2015;6:327 pubmed publisher
Draghiciu O, Nijman H, Hoogeboom B, Meijerhof T, Daemen T. Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication. Oncoimmunology. 2015;4:e989764 pubmed
Hou H, Liu W, Wu S, Lu Y, Peng J, Zhu Y, et al. Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock. PLoS ONE. 2014;9:e110585 pubmed publisher
Lo Sasso G, Menzies K, Mottis A, Piersigilli A, Perino A, Yamamoto H, et al. SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis. PLoS ONE. 2014;9:e103573 pubmed publisher
Smigiel K, Richards E, Srivastava S, Thomas K, Dudda J, Klonowski K, et al. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J Exp Med. 2014;211:121-36 pubmed publisher
Tewalt E, Cohen J, Rouhani S, Guidi C, Qiao H, Fahl S, et al. Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Blood. 2012;120:4772-82 pubmed publisher
Yamashita J, Iwamura C, Mitsumori K, Hosokawa H, Sasaki T, Takahashi M, et al. Murine Schnurri-2 controls natural killer cell function and lymphoma development. Leuk Lymphoma. 2012;53:479-86 pubmed publisher
Savage A, Constantinides M, Han J, Picard D, Martin E, Li B, et al. The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity. 2008;29:391-403 pubmed publisher
Albu D, Feng D, Bhattacharya D, Jenkins N, Copeland N, Liu P, et al. BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med. 2007;204:3003-15 pubmed
McKinstry K, Golech S, Lee W, Huston G, Weng N, Swain S. Rapid default transition of CD4 T cell effectors to functional memory cells. J Exp Med. 2007;204:2199-211 pubmed
Crozat K, Hoebe K, Ugolini S, Hong N, Janssen E, Rutschmann S, et al. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med. 2007;204:853-63 pubmed
Anis M, Fulton S, Reba S, Harding C, Boom W. Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection. Infect Immun. 2007;75:2260-8 pubmed
Hirota K, Hashimoto M, Yoshitomi H, Tanaka S, Nomura T, Yamaguchi T, et al. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med. 2007;204:41-7 pubmed
Ha S, Tsuji M, Suzuki K, Meek B, Yasuda N, Kaisho T, et al. Regulation of B1 cell migration by signals through Toll-like receptors. J Exp Med. 2006;203:2541-50 pubmed
Kao H, Allen P. An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4. J Exp Med. 2005;201:149-58 pubmed
Herman A, Freeman G, Mathis D, Benoist C. CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med. 2004;199:1479-89 pubmed
Goodyear C, Silverman G. Death by a B cell superantigen: In vivo VH-targeted apoptotic supraclonal B cell deletion by a Staphylococcal Toxin. J Exp Med. 2003;197:1125-39 pubmed
Daniel D, Meyer Morse N, Bergsland E, Dehne K, Coussens L, Hanahan D. Immune enhancement of skin carcinogenesis by CD4+ T cells. J Exp Med. 2003;197:1017-28 pubmed
Prlic M, Blazar B, Farrar M, Jameson S. In vivo survival and homeostatic proliferation of natural killer cells. J Exp Med. 2003;197:967-76 pubmed
product information
Product Type :
Antibody
Product Name :
CD69 Monoclonal Antibody (H1.2F3), Functional Grade, eBioscience™
Catalog # :
16-0691-85
Quantity :
500µg
Price :
US 310
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent
Species :
Mouse
Clone :
H1.2F3
Isotype :
IgG
Storage :
4° C
Description :
CD69 (AIM, Active Inducer Molecule) is a gp28/34 disulfide bonded homodimer with a molecular weight of 60 kDa under non-reducing conditions. CD69 contains one or two N linked oligosacaride and the molecule is present on activated platelets. In normal peripheral blood a variable percentage of cells express the CD69 antigen, and it is involved in lymphocyte signal transduction. Expression CD69 is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. Alternative splicing results in multiple transcript variants of CD69. Diseases associated with CD69 dysfunction include coccidiodomycosis and asthma.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent
Aliases :
5830438K24Rik; Activation inducer molecule; activation inducer molecule (AIM/CD69); AI452015; AIM; BL-AC/P26; Cd69; CD69 antigen; CD69 antigen (p60, early T-cell activation antigen); Cd69 molecule; CLEC2C; C-type lectin domain family 2 member C; C-type lectin domain family 2, member C; EA1; Early activation antigen CD69; early lymphocyte activation antigen; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3; VEA; Very Early Activation Antigen
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA