product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD49d (Integrin alpha 4) Monoclonal Antibody (9F10), Functional Grade, eBioscience™
catalog :
16-0499-85
quantity :
500µg
price :
US 323
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9F10
reactivity :
human
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 36
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 2a
Jürets A, Le Bras M, Staffler G, Stein G, Leitner L, Neuhofer A, et al. Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin Cleavage. PLoS ONE. 2016;11:e0148333 pubmed publisher
Eppler F, Quast T, Kolanus W. Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion. PLoS ONE. 2017;12:e0172443 pubmed publisher
Achour A, Baychelier F, Besson C, Arnoux A, Marty M, Hannoun L, et al. Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients. J Immunol. 2014;192:503-11 pubmed publisher
Rodriguez M, Loyd C, Ding X, Karim A, MCDONALD D, Canaday D, et al. Mycobacterial phosphatidylinositol mannoside 6 (PIM6) up-regulates TCR-triggered HIV-1 replication in CD4+ T cells. PLoS ONE. 2013;8:e80938 pubmed publisher
Groeneveld K, Hietbrink F, Hardcastle T, Warren B, Koenderman L, Leenen L. Penetrating thorax injury leads to mild systemic activation of neutrophils without inflammatory complications. Injury. 2014;45:522-7 pubmed publisher
Pham V, Nakayama M, Itoh Y, Ishigaki H, Kitano M, Arikata M, et al. Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. PLoS ONE. 2013;8:e75910 pubmed publisher
Cimato T, Palka B, Lang J, Young R. LDL cholesterol modulates human CD34+ HSPCs through effects on proliferation and the IL-17 G-CSF axis. PLoS ONE. 2013;8:e73861 pubmed publisher
Rueda C, Velilla P, Chougnet C, Rugeles M. Incomplete normalization of regulatory t-cell frequency in the gut mucosa of Colombian HIV-infected patients receiving long-term antiretroviral treatment. PLoS ONE. 2013;8:e71062 pubmed publisher
Chu C, Celik E, Rico F, Moy V. Elongated membrane tethers, individually anchored by high affinity ?4?1/VCAM-1 complexes, are the quantal units of monocyte arrests. PLoS ONE. 2013;8:e64187 pubmed publisher
Tadzić R, Mihalj M, Vcev A, Ennen J, Tadzic A, Drenjancevic I. The effects of arterial blood pressure reduction on endocan and soluble endothelial cell adhesion molecules (CAMs) and CAMs ligands expression in hypertensive patients on Ca-channel blocker therapy. Kidney Blood Press Res. 2013;37:103-15 pubmed publisher
Lim S, Kim T, Lee J, Sonn C, Kim K, Kim J, et al. Ex vivo expansion of highly cytotoxic human NK cells by cocultivation with irradiated tumor cells for adoptive immunotherapy. Cancer Res. 2013;73:2598-607 pubmed publisher
Demberg T, Brocca Cofano E, Kuate S, Aladi S, Vargas Inchaustegui D, Venzon D, et al. Impact of antibody quality and anamnestic response on viremia control post-challenge in a combined Tat/Env vaccine regimen in rhesus macaques. Virology. 2013;440:210-21 pubmed publisher
Harker K, Ueno N, Wang T, Bonhomme C, Liu W, Lodoen M. Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress. J Leukoc Biol. 2013;93:789-800 pubmed publisher
Scotta C, Esposito M, Fazekasova H, Fanelli G, Edozie F, Ali N, et al. Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations. Haematologica. 2013;98:1291-9 pubmed publisher
Claassen M, de Knegt R, Turgut D, Groothuismink Z, Janssen H, Boonstra A. Negative regulation of hepatitis C virus specific immunity is highly heterogeneous and modulated by pegylated interferon-alpha/ribavirin therapy. PLoS ONE. 2012;7:e49389 pubmed publisher
Martorelli D, Guidoboni M, De Re V, Muraro E, Turrini R, Merlo A, et al. IGKV3 proteins as candidate "off-the-shelf" vaccines for kappa-light chain-restricted B-cell non-Hodgkin lymphomas. Clin Cancer Res. 2012;18:4080-91 pubmed publisher
Betts G, Jones E, Junaid S, El Shanawany T, Scurr M, Mizen P, et al. Suppression of tumour-specific CD4? T cells by regulatory T cells is associated with progression of human colorectal cancer. Gut. 2012;61:1163-71 pubmed publisher
Li Q, Ding X, Thomas J, Harding C, Pecora N, Ziady A, et al. Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4+ T cells through VLA-5. J Leukoc Biol. 2012;91:311-20 pubmed publisher
Pillay J, Kamp V, van Hoffen E, Visser T, Tak T, Lammers J, et al. A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. J Clin Invest. 2012;122:327-36 pubmed publisher
Hildebrandt M, Dijkstra D, Gollasch H, Daemen K, Stevanovic Meyer M, Ludwig W. Apheresis-related enrichment of CD26++ T lymphocytes: phenotypic characterization and correlation with unfavorable outcome in autologous hematopoietic progenitor cell transplantation. Transfusion. 2012;52:765-76 pubmed publisher
Abdi J, Engels F, Garssen J, Redegeld F. Toll-like receptor-9 triggering modulates expression of ?-4 integrin on human B lymphocytes and their adhesion to extracellular matrix proteins. Exp Hematol. 2011;39:927-33 pubmed publisher
Lakhashe S, Velu V, Sciaranghella G, Siddappa N, Dipasquale J, Hemashettar G, et al. Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine. 2011;29:5611-22 pubmed publisher
Bao H, Lu P, Li Y, Wang L, Li H, He D, et al. Triggering of toll-like receptor-4 in human multiple myeloma cells promotes proliferation and alters cell responses to immune and chemotherapy drug attack. Cancer Biol Ther. 2011;11:58-67 pubmed publisher
Hovhannisyan Z, Treatman J, Littman D, Mayer L. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 2011;140:957-65 pubmed publisher
Sciaranghella G, Lakhashe S, Ayash Rashkovsky M, Mirshahidi S, Siddappa N, Novembre F, et al. A live attenuated Listeria monocytogenes vaccine vector expressing SIV Gag is safe and immunogenic in macaques and can be administered repeatedly. Vaccine. 2011;29:476-86 pubmed publisher
Kim T, Kim N, Kang H, Kim E, Kim S, Ahn H, et al. FK506 causes cellular and functional defects in human natural killer cells. J Leukoc Biol. 2010;88:1089-97 pubmed publisher
Ali Z, Yan L, Plagman N, Reichenberg A, Hintz M, Jomaa H, et al. Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits. J Immunol. 2009;183:5407-17 pubmed publisher
Fortunati E, Kazemier K, Grutters J, Koenderman L, Van den Bosch v. Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease. Clin Exp Immunol. 2009;155:559-66 pubmed publisher
Shao L, Zhang W, Zhang S, Chen C, Jiang W, Xu Y, et al. Potent immune responses of Ag-specific Vgamma2Vdelta2+ T cells and CD8+ T cells associated with latent stage of Mycobacterium tuberculosis coinfection in HIV-1-infected humans. AIDS. 2008;22:2241-50 pubmed publisher
Lages C, Suffia I, Velilla P, Huang B, Warshaw G, Hildeman D, et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol. 2008;181:1835-48 pubmed
Ali Z, Shao L, Halliday L, Reichenberg A, Hintz M, Jomaa H, et al. Prolonged (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-driven antimicrobial and cytotoxic responses of pulmonary and systemic Vgamma2Vdelta2 T cells in macaques. J Immunol. 2007;179:8287-96 pubmed
Nakhaei Nejad M, Hussain A, Zhang Q, Murray A. Endothelial PI 3-kinase activity regulates lymphocyte diapedesis. Am J Physiol Heart Circ Physiol. 2007;293:H3608-16 pubmed
Jafarshad A, Dziegiel M, Lundquist R, Nielsen L, Singh S, Druilhe P. A novel antibody-dependent cellular cytotoxicity mechanism involved in defense against malaria requires costimulation of monocytes FcgammaRII and FcgammaRIII. J Immunol. 2007;178:3099-106 pubmed
Rojas R, Thomas J, Gehring A, Hill P, Belisle J, Harding C, et al. Phosphatidylinositol mannoside from Mycobacterium tuberculosis binds alpha5beta1 integrin (VLA-5) on CD4+ T cells and induces adhesion to fibronectin. J Immunol. 2006;177:2959-68 pubmed
Kung S, Bonifacino A, Metzger M, Ringpis G, Donahue R, Chen I. Lentiviral vector-transduced dendritic cells induce specific T cell response in a nonhuman primate model. Hum Gene Ther. 2005;16:527-32 pubmed
Mueller Y, Petrovas C, Bojczuk P, Dimitriou I, Beer B, Silvera P, et al. Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques. J Virol. 2005;79:4877-85 pubmed
product information
Product Type :
Antibody
Product Name :
CD49d (Integrin alpha 4) Monoclonal Antibody (9F10), Functional Grade, eBioscience™
Catalog # :
16-0499-85
Quantity :
500µg
Price :
US 323
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent
Species :
Human
Clone :
9F10
Isotype :
IgG1, kappa
Storage :
4° C
Description :
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent
Aliases :
269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49D; IA4; integrin alpha 4; Integrin alpha-4; integrin alpha4B; Integrin alpha-IV; integrin subunit alpha 4; integrin, alpha 4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); ITGA4; Itga4B; ITGA-IV; LPAM subunit alpha; Lymphocyte Peyer patch adhesion molecules subunit alpha; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA