CD49b (Integrin alpha 2) Monoclonal Antibody (HMa2), Functional Grade, eBioscience™ | Invitrogen 16-0491-81 product information

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product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD49b (Integrin alpha 2) Monoclonal Antibody (HMa2), Functional Grade, eBioscience™

catalog :

16-0491-81

quantity :

50 µg

price :

US 309.00

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

HMa2

reactivity :

mouse

application :

flow cytometry

citations: 3

Reference
Meng C, Li Z, Fang W, Song Z, Yang D, Li D, et al. Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy. J Cell Mol Med. 2017;21:697-710 pubmed publisher
Krneta T, Gillgrass A, Chew M, Ashkar A. The breast tumor microenvironment alters the phenotype and function of natural killer cells. Cell Mol Immunol. 2016;13:628-39 pubmed publisher
Himoudi N, Yan M, Bouma G, Morgenstern D, Wallace R, Seddon B, et al. Migratory and antigen presentation functions of IFN-producing killer dendritic cells. Cancer Res. 2009;69:6598-606 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD49b (Integrin alpha 2) Monoclonal Antibody (HMa2), Functional Grade, eBioscience™

Catalog # :

16-0491-81

Quantity :

50 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent

Species :

Mouse

Clone :

HMa2

Isotype :

IgG

Storage :

4° C

Description :

CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent

Aliases :

alpha 2 subunit of VLA-2 receptor; BDPLT9; BR; CD49 antigen-like family member B; CD49B; Collagen receptor; DX5; GPIa; HPA-5; human platelet alloantigen system 5; integrin alpha 2; integrin alpha-2; integrin subunit alpha 2; integrin, alpha 2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); ITGA2; platelet antigen Br; platelet glycoprotein GPIa; platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2; VLA2 receptor; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha; VLAA2