CD48 Monoclonal Antibody (eBio156-4H9 (156-4H9)), Functional Grade, eBioscience | Invitrogen 16-0489-81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD48 Monoclonal Antibody (eBio156-4H9 (156-4H9)), Functional Grade, eBioscience

catalog :

16-0489-81

quantity :

50 ug

price :

US 133.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

eBio156-4H9 (156-4H9)

reactivity :

human

application :

flow cytometry

citations: 5

Reference
Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, et al. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014;211:2119-34 pubmed publisher
Pacheco Y, McLean A, Rohrbach J, Porichis F, Kaufmann D, Kavanagh D. Simultaneous TCR and CD244 signals induce dynamic downmodulation of CD244 on human antiviral T cells. J Immunol. 2013;191:2072-81 pubmed publisher
Negash A, RAMOS H, Crochet N, Lau D, DOEHLE B, Papic N, et al. IL-1? production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease. PLoS Pathog. 2013;9:e1003330 pubmed publisher
Hosen N, Ichihara H, Mugitani A, Aoyama Y, Fukuda Y, Kishida S, et al. CD48 as a novel molecular target for antibody therapy in multiple myeloma. Br J Haematol. 2012;156:213-24 pubmed publisher
Katagiri T, Qi Z, Ohtake S, Nakao S. GPI-anchored protein-deficient T cells in patients with aplastic anemia and low-risk myelodysplastic syndrome: implications for the immunopathophysiology of bone marrow failure. Eur J Haematol. 2011;86:226-36 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD48 Monoclonal Antibody (eBio156-4H9 (156-4H9)), Functional Grade, eBioscience

Catalog # :

16-0489-81

Quantity :

50 ug

Price :

US 133.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.5 ug/test, Functional Assay: Assay-Dependent

Species :

Human

Clone :

eBio156-4H9 (156-4H9)

Isotype :

IgG1

Storage :

4 C

Description :

CD48 (Blast-1) belongs to the CD2 subset of the Ig superfamily that includes CD2, CD2F-10, CD58, CD84, CD150, CD229, CD244 and others. These molecules bind to the same or another members of the Ig family, thus mediating homotypic or heterotypic adhesion. CD48 is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as a high affinity ligand for 2B4 and low affinity ligand for CD2. 2B4-CD48 interaction among NK cells and NK-T cells regulates cell proliferation. Further, signaling through CD48 results in eosinophil activation and CD48 expression is increased in several infectious diseases. CD48 is strongly expressed on lymphocytes and monocytes, weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of marker for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2. 2B4-CD48 interaction may be involved in the pathology of allergic airway diseases and provide a pharmacological target for the treatment of diseases such as allergic rhinitis and asthma.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test, Functional Assay: Assay-Dependent

Aliases :

AI449234; AW610730; B-cell activation marker; BCM1; Bcm-1; BCM1 surface antigen; BLAST; BLAST1; BLAST-1; B-lymphocyte activation marker BLAST-1; Cd48; CD48 antigen; CD48 antigen (B cell membrane protein); CD48 antigen (B-cell membrane protein); Cd48 molecule; CD48d; hCD48; HM48-1; leukocyte antigen MEM-102; mCD48; MEM-102; MRC OX-45 surface antigen; sCD 48; sCD48; Sgp-60; Signaling lymphocytic activation molecule 2; Signaling lymphocytic activation molecule 2 (SLAMF2); SLAM family member 2; SLAMF2; soluble CD 48; soluble CD48; TCT.1