product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD47 Monoclonal Antibody (B6H12), Functional Grade, eBioscience
catalog :
16-0479-95
quantity :
10 mg
price :
US 3320.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B6H12
reactivity :
human, mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 21
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 1d
  • flow cytometry; mouse; loading ...; fig 1c
Myers D, Abram C, Wildes D, Belwafa A, Welsh A, Schulze C, et al. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020;11:576310 pubmed publisher
D xf6 ring M, Brux M, Paszkowski Rogacz M, Guillem Gloria P, Buchholz F, Pisabarro M, et al. Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancer. Life Sci Alliance. 2024;7: pubmed publisher
Yu P, Hao C, Fan Y, Liu D, Qiao Y, Yao J, et al. Altered Membrane Expression and Function of CD11b Play a Role in the Immunosuppressive Effects of Morphine on Macrophages at the Nanomolar Level. Pharmaceuticals (Basel). 2023;16: pubmed publisher
Augustin S, Lam M, Lavalette S, Verschueren A, Blond F, Forster V, et al. Melanophages give rise to hyperreflective foci in AMD, a disease-progression marker. J Neuroinflammation. 2023;20:28 pubmed publisher
Zhang R, Neighbors J, Schell T, Hohl R. Schweinfurthin induces ICD without ER stress and caspase activation. Oncoimmunology. 2022;11:2104551 pubmed publisher
Xu C, Li J, Jiang S, Wan L, Zhang X, Xia L, et al. CD47 Blockade Accelerates Blood Clearance and Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage. Front Immunol. 2022;13:823999 pubmed publisher
McAndrews K, Xiao F, Chronopoulos A, LeBleu V, Kugeratski F, Kalluri R. Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer. Life Sci Alliance. 2021;4: pubmed publisher
Wang J, Zhang H, Yin X, Bian Y. Anti-CD47 antibody synergizes with cisplatin against laryngeal cancer by enhancing phagocytic ability of macrophages. Clin Exp Immunol. 2021;205:333-342 pubmed publisher
Xu S, Wang X, Yang Y, Li Y, Wu S. LSD1 silencing contributes to enhanced efficacy of anti-CD47/PD-L1 immunotherapy in cervical cancer. Cell Death Dis. 2021;12:282 pubmed publisher
Lerbs T, Cui L, King M, Chai T, Muscat C, Chung L, et al. CD47 prevents the elimination of diseased fibroblasts in scleroderma. JCI Insight. 2020;5: pubmed publisher
von Roemeling C, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, et al. Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity. Nat Commun. 2020;11:1508 pubmed publisher
Wei J, Wang M, Jing C, Keep R, Hua Y, Xi G. Multinucleated Giant Cells in Experimental Intracerebral Hemorrhage. Transl Stroke Res. 2020;11:1095-1102 pubmed publisher
Mair B, Aldridge P, Atwal R, Philpott D, Zhang M, Masud S, et al. High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting. Nat Biomed Eng. 2019;3:796-805 pubmed publisher
Jing C, Bian L, Wang M, Keep R, Xi G, Hua Y. Enhancement of Hematoma Clearance With CD47 Blocking Antibody in Experimental Intracerebral Hemorrhage. Stroke. 2019;50:1539-1547 pubmed publisher
Logtenberg M, Jansen J, Raaben M, Toebes M, Franke K, Brandsma A, et al. Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Nat Med. 2019;25:612-619 pubmed publisher
Guillon J, Petit C, Moreau M, Toutain B, Henry C, Roche H, et al. Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment. Cell Death Dis. 2019;10:199 pubmed publisher
Mendt M, Kamerkar S, Sugimoto H, McAndrews K, Wu C, Gagea M, et al. Generation and testing of clinical-grade exosomes for pancreatic cancer. JCI Insight. 2018;3: pubmed publisher
Hain A, Krämer M, Linka R, Nakhaei Rad S, Ahmadian M, Häussinger D, et al. IL-2 Inducible Kinase ITK is Critical for HIV-1 Infection of Jurkat T-cells. Sci Rep. 2018;8:3217 pubmed publisher
Chen J, Zhong M, Guo H, Davidson D, Mishel S, Lu Y, et al. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature. 2017;544:493-497 pubmed publisher
Liu R, Wei H, Gao P, Yu H, Wang K, Fu Z, et al. CD47 promotes ovarian cancer progression by inhibiting macrophage phagocytosis. Oncotarget. 2017;8:39021-39032 pubmed publisher
Abreu M, Sealy L. Cells expressing the C/EBPbeta isoform, LIP, engulf their neighbors. PLoS ONE. 2012;7:e41807 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD47 Monoclonal Antibody (B6H12), Functional Grade, eBioscience
Catalog # :
16-0479-95
Quantity :
10 mg
Price :
US 3320.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Species :
Human
Clone :
B6H12
Isotype :
IgG1, kappa
Storage :
4 C
Description :
CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Functionally, CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. CD47 is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. CD47 has broad tissue distribution, is reduced in expression on Rh erythrocytes. CD47 acts as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion, T cell activation, and is involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Aliases :
9130415E20Rik; AA407862; AI848868; antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; AW108519; B430305P08Rik; Cd47; CD47 antigen; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); CD47 antigen/integrin-associated protein; CD47 glycoprotein; CD47 molecule; CD47/IAP; IAP; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; Itgp; Leukocyte surface antigen CD47; MER6; OA3; Protein MER6; Rh-related antigen; sCD47; soluble CD 47; soluble CD47
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA