CD40 Monoclonal Antibody (5C3), Functional Grade, eBioscience™ | Invitrogen 16-0409-85 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD40 Monoclonal Antibody (5C3), Functional Grade, eBioscience™

catalog :

16-0409-85

quantity :

500µg

price :

US 359

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5C3

reactivity :

human

application :

flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 1a	Richardson J, Armbruster N, Günter M, Henes J, Autenrieth S. Staphylococcus aureus PSM Peptides Modulate Human Monocyte-Derived Dendritic Cells to Prime Regulatory T Cells. Front Immunol. 2018;9:2603 pubmed publisher
blocking or activating experiments; human; loading ...; fig 7a	Harfuddin Z, Dharmadhikari B, Wong S, Duan K, Poidinger M, Kwajah S, et al. Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype. Sci Rep. 2016;6:29712 pubmed publisher
flow cytometry; human; fig 1	Boltjes A, van Montfoort N, Biesta P, Op den Brouw M, Kwekkeboom J, van der Laan L, et al. Kupffer cells interact with hepatitis B surface antigen in vivo and in vitro, leading to proinflammatory cytokine production and natural killer cell function. J Infect Dis. 2015;211:1268-78 pubmed publisher
	Lemarquis A, Einarsdóttir H, Kristjansdottir R, Jonsdottir I, Ludviksson B. Transitional B Cells and TLR9 Responses Are Defective in Selective IgA Deficiency. Front Immunol. 2018;9:909 pubmed publisher
	Ventura Ferreira M, Bienert M, Muller K, Rath B, Goecke T, Opländer C, et al. Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta. Stem Cell Res Ther. 2018;9:28 pubmed publisher
	Chevrier S, Levine J, Zanotelli V, Silina K, Schulz D, Bacac M, et al. An Immune Atlas of Clear Cell Renal Cell Carcinoma. Cell. 2017;169:736-749.e18 pubmed publisher
	Pathangey L, McCurry D, Gendler S, Dominguez A, Gorman J, Pathangey G, et al. Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens. Oncotarget. 2017;8:10785-10808 pubmed publisher
	Zhu H, Hu F, Sun X, Zhang X, Zhu L, Liu X, et al. CD16+ Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus. Front Immunol. 2016;7:512 pubmed
	Boulter N, Suarez F, Schibeci S, Sunderland T, Tolhurst O, Hunter T, et al. A simple, accurate and universal method for quantification of PCR. BMC Biotechnol. 2016;16:27 pubmed publisher
	Matsuzaki J, Tsuji T, Luescher I, Shiku H, Mineno J, Okamoto S, et al. Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses. Sci Rep. 2015;5:14896 pubmed publisher
	Zhang G, Huang H, Zhu Y, Yu G, Gao X, Xu Y, et al. A novel subset of B7-H3+CD14+HLA-DR-/low myeloid-derived suppressor cells are associated with progression of human NSCLC. Oncoimmunology. 2015;4:e977164 pubmed
	Wheway J, Latham S, Combes V, Grau G. Endothelial microparticles interact with and support the proliferation of T cells. J Immunol. 2014;193:3378-87 pubmed publisher
	Wang D, Feng X, Lu L, Konkel J, Zhang H, Chen Z, et al. A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus. Arthritis Rheumatol. 2014;66:2234-45 pubmed publisher
	Fuchs A, Atkinson J, Fremeaux Bacchi V, Kemper C. CD46-induced human Treg enhance B-cell responses. Eur J Immunol. 2009;39:3097-109 pubmed publisher
	Azakami K, Sato T, Araya N, Utsunomiya A, Kubota R, Suzuki K, et al. Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders. Blood. 2009;114:3208-15 pubmed publisher
	Kato A, Truong Tran A, Scott A, Matsumoto K, Schleimer R. Airway epithelial cells produce B cell-activating factor of TNF family by an IFN-beta-dependent mechanism. J Immunol. 2006;177:7164-72 pubmed

product information

Product Type :

Antibody

Product Name :

CD40 Monoclonal Antibody (5C3), Functional Grade, eBioscience™

Catalog # :

16-0409-85

Quantity :

500µg

Price :

US 359

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent

Species :

Human

Clone :

5C3

Isotype :

IgG1, kappa

Storage :

4° C

Description :

The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent

Aliases :

AI326936; B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; BOS_13299; Bp50; CD antigen CD40; CD40; CD40 antigen; CD40 antigen (TNF receptor superfamily member 5); CD40 antigen, TNF receptor superfamily member 5; CD40 molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; GP39; HIGM1; I79_006806; IGM; IMD3; Immunoglobulin M; ImmunoglobulinM; LOC100349106; membrane protein CD40; MGC9013; p50; sCD40; soluble CD40; T-BAM; T-cell differentiation antigen; Tnfrsf5; TRAP; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5

more info or order :

Invitrogen product webpage