This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD40 Monoclonal Antibody (HM40-3), Functional Grade, eBioscience
catalog :
16-0402-025
quantity :
25 mg
price :
US 9220.00
clonality :
monoclonal
host :
hamsters
conjugate :
nonconjugated
clone name :
HM40-3

The same clone is also sold as:
reactivity :
mouse, rat
application :
flow cytometry
citations: 38
Reference
Yan C, Kuang W, Jin L, Wang R, Niu L, Xie C, et al. Carvacrol protects mice against LPS-induced sepsis and attenuates inflammatory response in macrophages by modulating the ERK1/2 pathway. Sci Rep. 2023;13:12809 pubmed publisher
Feng L, Luo G, Li Y, Zhang C, Liu Y, Liu Y, et al. Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis. Vet Res. 2023;54:25 pubmed publisher
Venturutti L, Rivas M, Pelzer B, Fl xfc mann R, Hansen J, Karagiannidis I, et al. An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas. Cancer Discov. 2023;13:216-243 pubmed publisher
Mirlekar B, Wang Y, Li S, Zhou M, Entwistle S, De Buysscher T, et al. Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity. Cell Rep Med. 2022;3:100744 pubmed publisher
Lv N, Jin S, Liang Z, Wu X, Kang Y, Su L, et al. PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway. Front Immunol. 2021;12:751409 pubmed publisher
Jiang Y, Dong Y, Luo Y, Jiang S, Meng F, Tan M, et al. AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ. Cell Rep. 2021;34:108713 pubmed publisher
Yang D, Sun Y, Chen J, Zhang Y, Fan S, Huang M, et al. REV7 is required for processing AID initiated DNA lesions in activated B cells. Nat Commun. 2020;11:2812 pubmed publisher
Liu X, Liu T, Shang Y, Dai P, Zhang W, Lee B, et al. ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells. Cell Res. 2020;30:732-744 pubmed publisher
Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, et al. Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses. Commun Biol. 2020;3:163 pubmed publisher
Tian M, McGovern K, Cheng H, Waddicor P, Rieble L, Dao M, et al. Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models. Proc Natl Acad Sci U S A. 2020;117:7929-7940 pubmed publisher
Wang Z, Zhao M, Yin J, Liu L, Hu L, Huang Y, et al. E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases. J Clin Invest. 2020;130:3717-3733 pubmed publisher
Schoeler K, Aufschnaiter A, Messner S, Derudder E, Herzog S, Villunger A, et al. TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells. FEBS J. 2019;286:3566-3581 pubmed publisher
Yen W, Sharma R, Cols M, Lau C, Chaudhry A, Chowdhury P, et al. Distinct Requirements of CHD4 during B Cell Development and Antibody Response. Cell Rep. 2019;27:1472-1486.e5 pubmed publisher
Li Q, Liu C, Yue R, El Ashram S, Wang J, He X, et al. cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection. Int J Mol Sci. 2019;20: pubmed publisher
Pucella J, Cols M, Yen W, Xu S, Chaudhuri J. The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses. J Immunol. 2019;202:1383-1396 pubmed publisher
Chen J, Cai Z, Bai M, Yu X, Zhang C, Cao C, et al. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. Cell Res. 2018;28:981-995 pubmed publisher
Hung P, Johnson B, Chen B, Byrum A, Bredemeyer A, Yewdell W, et al. MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell. 2018;71:332-342.e8 pubmed publisher
Willis S, Tellier J, Liao Y, Trezise S, Light A, O Donnell K, et al. Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB. Nat Commun. 2017;8:1426 pubmed publisher
Wang H, Lin J, Zeng L, Ouyang C, Ran P, Yang P, et al. Der f 31, a novel allergen from Dermatophagoides farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells. Sci Rep. 2017;7:8519 pubmed publisher
Wang H, Hu W, Liang Z, Zeng L, Li J, Yan H, et al. Thiol peroxiredoxin, a novel allergen from Bombyx mori, modulates functions of macrophages and dendritic cells. Am J Transl Res. 2016;8:5320-5329 pubmed
Xue D, Desjardins M, Kaufman G, Beland M, Al Tamemi S, Ahmed E, et al. Semaphorin 4C: A Novel Component of B-Cell Polarization in Th2-Driven Immune Responses. Front Immunol. 2016;7:558 pubmed publisher
Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, et al. Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining. Proc Natl Acad Sci U S A. 2016;113:1256-60 pubmed publisher
Masani S, Han L, Meek K, Yu K. Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination. Proc Natl Acad Sci U S A. 2016;113:1261-6 pubmed publisher
Davari K, Frankenberger S, Schmidt A, Tomi N, Jungnickel B. Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle. 2014;13:3659-69 pubmed publisher
Lu Y, Zhang M, Wang S, Hong B, Wang Z, Li H, et al. p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression. Nat Commun. 2014;5:4229 pubmed publisher
Han L, Masani S, Hsieh C, Yu K. DNA ligase I is not essential for mammalian cell viability. Cell Rep. 2014;7:316-320 pubmed publisher
Lin W, Hildebrand J, Bishop G. A Complex Relationship between TRAF3 and Non-Canonical NF-?B2 Activation in B Lymphocytes. Front Immunol. 2013;4:477 pubmed publisher
Jin H, Oda H, Lai M, Skalsky R, Bethel K, Shepherd J, et al. MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. EMBO J. 2013;32:2377-91 pubmed publisher
Innes C, Hesse J, Palii S, Helmink B, Holub A, Sleckman B, et al. DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs. BMC Genomics. 2013;14:163 pubmed publisher
Masani S, Han L, Yu K. Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination. Mol Cell Biol. 2013;33:1468-73 pubmed publisher
Kamphuis T, Meijerhof T, Stegmann T, Lederhofer J, Wilschut J, de Haan A. Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice. PLoS ONE. 2012;7:e36812 pubmed publisher
Han L, Mao W, Yu K. X-ray repair cross-complementing protein 1 (XRCC1) deficiency enhances class switch recombination and is permissive for alternative end joining. Proc Natl Acad Sci U S A. 2012;109:4604-8 pubmed publisher
Xie P, Poovassery J, Stunz L, Smith S, Schultz M, Carlin L, et al. Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes. J Leukoc Biol. 2011;90:1149-57 pubmed publisher
Han L, Masani S, Yu K. Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination. Proc Natl Acad Sci U S A. 2011;108:11584-9 pubmed publisher
Boboila C, Jankovic M, Yan C, Wang J, Wesemann D, Zhang T, et al. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010;107:3034-9 pubmed publisher
Edukulla R, Ramakrishna E, Woller N, Mundt B, Knocke S, Gürlevik E, et al. Antitumoral immune response by recruitment and expansion of dendritic cells in tumors infected with telomerase-dependent oncolytic viruses. Cancer Res. 2009;69:1448-58 pubmed publisher
de Haas A, Boddeke H, Biber K. Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS. Glia. 2008;56:888-94 pubmed publisher
Xiao C, Calado D, Galler G, Thai T, Patterson H, Wang J, et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell. 2007;131:146-59 pubmed
product information
Product Type :
Antibody
Product Name :
CD40 Monoclonal Antibody (HM40-3), Functional Grade, eBioscience
Catalog # :
16-0402-025
Quantity :
25 mg
Price :
US 9220.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Mouse, Rat
Applications :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Species :
Mouse, Rat
Clone :
HM40-3
Isotype :
IgM, kappa
Storage :
4 C
Description :
The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Aliases :
AI326936; B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; Cd40; CD40 antigen; CD40 antigen (TNF receptor superfamily member 5); CD40 antigen, TNF receptor superfamily member 5; CD40 molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; GP39; HIGM1; I79_006806; IGM; IMD3; Immunoglobulin M; ImmunoglobulinM; membrane protein CD40; MGC9013; p50; receptor for ligand CD154; sCD40; soluble CD40; T-BAM; T-cell differentiation antigen; Tnfrsf5; TRAP; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA