This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD40 Monoclonal Antibody (1C10), Functional Grade, eBioscience
catalog :
16-0401-025
quantity :
25 mg
price :
US 9350.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
1C10

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 52
Reference
Liu C, Guo S, Liu R, Guo M, Wang Q, Chai Z, et al. Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis. Neural Regen Res. 2024;19:671-679 pubmed publisher
Ramzy A, Soliman A, Hassanein S, Sebak A. Multitarget, multiagent PLGA nanoparticles for simultaneous tumor eradication and TME remodeling in a melanoma mouse model. Drug Deliv Transl Res. 2024;14:491-509 pubmed publisher
Lutz M, Ali S, Audiger C, Autenrieth S, Berod L, Bigley V, et al. Guidelines for mouse and human DC generation. Eur J Immunol. 2022;: pubmed publisher
Jing Z, McCarron M, Dustin M, Fooksman D. Germinal center expansion but not plasmablast differentiation is proportional to peptide-MHCII density via CD40-CD40L signaling strength. Cell Rep. 2022;39:110763 pubmed publisher
Wang Z, Xu F, Hu J, Zhang H, Cui L, Lu W, et al. Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity. J Immunother Cancer. 2021;9: pubmed publisher
Agalave N, Mody P, Szabo Pardi T, Jeong H, Burton M. Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy. Front Immunol. 2021;12:642420 pubmed publisher
Diao G, Huang J, Zheng X, Sun X, Tian M, Han J, et al. Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells. Int J Mol Med. 2021;47:207-218 pubmed publisher
Chen H, Tan J, Li X, Li H, Wu W, Wu Y, et al. Myeloid and plasmacytoid dendritic cell combined vaccines loaded with heat-treated tumor cell lysates enhance antitumor activity in murine lung cancer. Oncol Lett. 2021;21:90 pubmed publisher
Huang D, Tran J, Olson A, Vollbrecht T, Tenuta M, Guryleva M, et al. Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells. Nat Commun. 2020;11:5850 pubmed publisher
Darling R, Senapati S, Christiansen J, Liu L, Ramer Tait A, Narasimhan B, et al. Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8+ T Cell Memory and Delayed Tumor Progression. Int J Nanomedicine. 2020;15:6579-6592 pubmed publisher
Iske J, Seyda M, Heinbokel T, Maenosono R, Minami K, Nian Y, et al. Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation. Nat Commun. 2020;11:4289 pubmed publisher
Olivieri M, Cho T, lvarez Quil n A, Li K, Schellenberg M, Zimmermann M, et al. A Genetic Map of the Response to DNA Damage in Human Cells. Cell. 2020;182:481-496.e21 pubmed publisher
Kedzierska A, Lorek D, Slawek A, Chelmonska Soyta A. Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings. Sci Rep. 2020;10:10531 pubmed publisher
Huang J, Diao G, Zhang Q, Chen Y, Han J, Guo J. E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions. Int J Oncol. 2020;56:921-931 pubmed publisher
Zhang H, Alsaleh G, Feltham J, Sun Y, Napolitano G, Riffelmacher T, et al. Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence. Mol Cell. 2019;76:110-125.e9 pubmed publisher
Wang Z, Chen J, Hu J, Zhang H, Xu F, He W, et al. cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity. J Clin Invest. 2019;129:4850-4862 pubmed publisher
Serradell M, Rupil L, Martino R, Prucca C, Carranza P, Saura A, et al. Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins. Nat Commun. 2019;10:361 pubmed publisher
Kornberg M, Smith M, Shirazi H, Calabresi P, Snyder S, Kim P. Bryostatin-1 alleviates experimental multiple sclerosis. Proc Natl Acad Sci U S A. 2018;115:2186-2191 pubmed publisher
Shen Y, Guo D, Weng L, Wang S, Ma Z, Yang Y, et al. Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway. Oncoimmunology. 2017;6:e1362527 pubmed publisher
Pan Y, Yu Y, Lin C, Lanier L, Chu C. Fc?RI ?-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells. Front Immunol. 2017;8:1424 pubmed publisher
Sato Kaneko F, Yao S, Ahmadi A, Zhang S, Hosoya T, Kaneda M, et al. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017;2: pubmed publisher
Wang J, Dai X, Hsu C, Ming C, He Y, Zhang J, et al. Discrimination of the heterogeneity of bone marrow‑derived dendritic cells. Mol Med Rep. 2017;16:6787-6793 pubmed publisher
Li Y, Liu X, Duan W, Tian H, Zhu G, He H, et al. Batf3-dependent CD8?+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages. EBioMedicine. 2017;18:188-198 pubmed publisher
Zhang H, Qi Y, Yuan Y, Cai L, Xu H, Zhang L, et al. Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation. Sci Rep. 2017;7:41887 pubmed publisher
Kreer C, Kuepper J, Zehner M, Quast T, Kolanus W, Schumak B, et al. N-glycosylation converts non-glycoproteins into mannose receptor ligands and reveals antigen-specific T cell responses in vivo. Oncotarget. 2017;8:6857-6872 pubmed publisher
Collinson Pautz M, Slawin K, Levitt J, Spencer D. MyD88/CD40 Genetic Adjuvant Function in Cutaneous Atypical Antigen-Presenting Cells Contributes to DNA Vaccine Immunogenicity. PLoS ONE. 2016;11:e0164547 pubmed publisher
Saini A, Mahajan S, Gupta P. Nuclear receptor expression atlas in BMDCs: Nr4a2 restricts immunogenicity of BMDCs and impedes EAE. Eur J Immunol. 2016;46:1842-53 pubmed publisher
Uto T, Fukaya T, Takagi H, Arimura K, Nakamura T, Kojima N, et al. Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity. Nat Commun. 2016;7:11273 pubmed publisher
Xu X, Gao Y, Zhai Z, Zhang S, Shan F, Feng J. Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS. Hum Vaccin Immunother. 2016;12:2169-2180 pubmed
Lund L, Ingmer H, Frøkiær H. D-Alanylation of Teichoic Acids and Loss of Poly-N-Acetyl Glucosamine in Staphylococcus aureus during Exponential Growth Phase Enhance IL-12 Production in Murine Dendritic Cells. PLoS ONE. 2016;11:e0149092 pubmed publisher
Ying W, Tseng A, Chang R, Wang H, Lin Y, Kanameni S, et al. miR-150 regulates obesity-associated insulin resistance by controlling B cell functions. Sci Rep. 2016;6:20176 pubmed publisher
Lagassé H, Anidi I, Craig J, Limjunyawong N, Poupore A, Mitzner W, et al. Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes. J Leukoc Biol. 2016;99:659-71 pubmed publisher
Otipoby K, Waisman A, Derudder E, Srinivasan L, Franklin A, Rajewsky K. The B-cell antigen receptor integrates adaptive and innate immune signals. Proc Natl Acad Sci U S A. 2015;112:12145-50 pubmed publisher
Casiraghi C, Márquez A, Shanina I, Horwitz M. Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis. Sci Rep. 2015;5:13995 pubmed publisher
Polte T, Petzold S, Bertrand J, Schütze N, Hinz D, Simon J, et al. Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation. Nat Commun. 2015;6:7554 pubmed publisher
Rose A, Hoffmann F, Hara J, Urschitz J, Moisyadi S, Hoffmann P, et al. Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses. Hum Vaccin Immunother. 2015;11:2305-11 pubmed publisher
Hobeika E, Levit Zerdoun E, Anastasopoulou V, Pohlmeyer R, Altmeier S, Alsadeq A, et al. CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk. EMBO J. 2015;34:925-39 pubmed publisher
Song L, Yang M, Knoff J, Wu T, Hung C. Cancer immunotherapy employing an innovative strategy to enhance CD4+ T cell help in the tumor microenvironment. PLoS ONE. 2014;9:e115711 pubmed publisher
Bhattacharya A, Parillon X, Zeng S, Han S, Eissa N. Deficiency of autophagy in dendritic cells protects against experimental autoimmune encephalomyelitis. J Biol Chem. 2014;289:26525-32 pubmed publisher
Rudulier C, McKinstry K, Al Yassin G, Kroeger D, Bretscher P. The number of responding CD4 T cells and the dose of antigen conjointly determine the TH1/TH2 phenotype by modulating B7/CD28 interactions. J Immunol. 2014;192:5140-50 pubmed publisher
Wang S, Wu B, Xue J, Wang M, Chen R, Wang B. Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge. Hum Vaccin Immunother. 2014;10:461-8 pubmed publisher
Kayes T, Fang Y, Yu S, Downey E, Wang S, Braley Mullen H. Agonistic anti-CD40 induces thyrocyte proliferation and promotes thyroid autoimmunity by increasing CD40 expression on thyroid epithelial cells. J Immunol. 2013;190:3928-38 pubmed publisher
Kim M, Kim T. R-phycoerythrin-conjugated antibodies are inappropriate for intracellular staining of murine plasma cells. Cytometry A. 2013;83:452-60 pubmed publisher
Malon J, Maddula S, Bell H, Cao L. Involvement of calcitonin gene-related peptide and CCL2 production in CD40-mediated behavioral hypersensitivity in a model of neuropathic pain. Neuron Glia Biol. 2011;7:117-28 pubmed publisher
Zhou X, Xiang Y, Ding X, Garrard W. A new hypersensitive site, HS10, and the enhancers, E3' and Ed, differentially regulate Ig? gene expression. J Immunol. 2012;188:2722-32 pubmed publisher
Qian J, Yi H, Guo C, Yu X, Zuo D, Chen X, et al. CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma. J Immunol. 2011;187:2905-14 pubmed publisher
Farrand K, Dickgreber N, Stoitzner P, Ronchese F, Petersen T, Hermans I. Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens. J Immunol. 2009;183:7732-42 pubmed publisher
Sanchez Aguilera A, Rattmann I, Drew D, Müller L, Summey V, Lucas D, et al. Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia. Leukemia. 2010;24:97-104 pubmed publisher
Siracusa M, Reece J, Urban J, Scott A. Dynamics of lung macrophage activation in response to helminth infection. J Leukoc Biol. 2008;84:1422-33 pubmed publisher
Lee S, Park Y, So T, Kwon B, Cheroutre H, Mittler R, et al. Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol. 2008;9:917-26 pubmed publisher
Lin K, Freeman S, Zabetian S, Brugger H, Weber M, Lei V, et al. The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands. Immunity. 2008;28:75-87 pubmed publisher
Kawasaki T, Choudhry M, Suzuki T, Schwacha M, Bland K, Chaudry I. 17beta-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-alpha. Mol Immunol. 2008;45:376-85 pubmed
product information
Product Type :
Antibody
Product Name :
CD40 Monoclonal Antibody (1C10), Functional Grade, eBioscience
Catalog # :
16-0401-025
Quantity :
25 mg
Price :
US 9350.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Species :
Mouse
Clone :
1C10
Isotype :
IgG2a, kappa
Storage :
4 C
Description :
The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Aliases :
AI326936; B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; Cd40; CD40 antigen; CD40 antigen (TNF receptor superfamily member 5); CD40 antigen, TNF receptor superfamily member 5; CD40 molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; GP39; HIGM1; I79_006806; IGM; IMD3; Immunoglobulin M; ImmunoglobulinM; membrane protein CD40; MGC9013; p50; receptor for ligand CD154; sCD40; soluble CD40; T-BAM; T-cell differentiation antigen; Tnfrsf5; TRAP; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA